I.O. Balaklytska Kharkiv Medical Akademy of Postgraduate Education This article addresses the issue of the part of melatonin—serotonin system in the mechanisms of formation of insomnia with GERD accompanied by NCD. We conducted a study of four groups of patients suffering from GERD with insomnia and from GERD accompanied by NCD with insomnia. Two groups…
Gastroenterology
The effect of adiponectin gene polymorphism on the severity of metabolic disorders and some liver parameters in patients with non-alcoholic fatty liver disease in combination with hypertension
K.О. Prosolenko Kharkiv National Medical University. The aim of the work was to study the relationship of the genetic polymorphism of the G276T marker of the ADIPOQ gene with the severity of metabolic disorders and changes in some liver indices with comorbidity of hypertension (Н) and non-alcoholic fatty liver disease (NAFLD). The object of the…
The role of endothelin-1 and melatonin in the mechanisms of the comorbid course of gastroesophageal reflux disease and obstructive sleep apnea syndrome
Prof. A.G. Oparin, M.A. Murghuzov Kharkiv Medical Academy of Postgraduate Education As revealed in studies in young patients with GERD, there is a statistically significant decrease in the level of melatonin metabolite (6-COM) and a statistically significant increase in the content of endothelin-1 compared with a group of healthy individuals of the same age and…
Family doctor’s tactics for biliary tract diseases (diagnostic criteria)
Ass.prof. K.V. Vovk, ass.prof. O.V. Sokruto, ass.prof. O.G. Reznichenko, ass.prof. S.V. Gridneva, M.V. Martynenko. Kharkiv National University bу V.N. Karazin. Volumes of work of the family doctor include diagnostics, treatment, multifactorial prevention of diseases of internal organs, which do not require treatment in the hospital. Diseases of the biliary system are one of the leading…
The role and place of ghrelin in the pathology of diseases of the gastrointestinal tract
A.A. Kudryavtsev Kharkiv Medical Academy of Postgraduate Education To date, diseases of the digestive system remain one of the most pressing problems of modern medicine. Much attention is paid to the biochemical and molecular mechanisms underlying the development of these pathologies. In recent years, new hormones and neurotransmitters have been discovered that regulate energy metabolism…
Assessment of fetuin-A in patients with comorbidity of non-alcoholic fatty liver disease and arterial hypertension
Ass.prof. К.О. Prosolenko Kharkiv National Medical University The aim of our study was to investigate serum fetuin A levels in patients with NAFLD and its comorbidity with essential hypertension or renoparenchymal hypertension, as well as to evaluate the association of this indicator with the major pathogenetic factors of these diseases. All patients were divided into…
Characteristics of motor-secretory disorders in patients with ischemicheart disease with concomitant gastroesophageal reflux disease
As.prof. A.S Vnukova Kharkiv medical academy of postgraduate education The goal of the study was to examine the characteristics of motor-secretory disorders in patients with ischemicheart disease (IHD) and gastroesophageal reflux disease (GERD). The present study was conducted with a total of 110 patients. The first group included 66 patients with IHD and concomitant GERD….
Еrosive and non-erosive forms of gastroesophageal reflux disease
Prof. T.D. Zvyagintseva , as.prof. Ya.K. Gamanenko Kharkiv Academy of Postgraduate Medicine The article deals with the issues of modern understanding of cellular and molecular mechanisms of the pathogenesis of GERD-associated inflammation of the esophagus mucosa involves complex and multifactorial immune-mediated effects of re-action of gastric reflux contents with varying pH values. Until recently, the…
The potential role of kallistatin as a new biomarker in non-invasivediagnostics of non-alcoholic fatty liver disease with hypertension
Prof. O.Ya. Babak, prof. N.M. Zhelezniakova, as.prof. A.O. Rozhdestvenska Kharkiv National Medical University It is known that non-alcoholic fatty liver disease (NAFLD) is recognized as one of the most common diseases in the 21st century. A variant of the comorbidity is the combination of NAFLD with the hypertension (HT) increasing the risks of non-alcoholic steatosis…
Microbiota and Network Medicine
Prof. Zh.D Semidotskaya, ass. prof. I.O Chernyakova, ass. prof. M.Yu. Neffa, A.E. Chernyakova Kharkiv National Medical University Kharkiv Regional Clinical Dispensary for Radiation Protection of the Population The article outlines the modern understanding of the microbiota as a decentralized network structure, is in constant feedback with the hierarchical network of the host, his brain, cardiovascular, respiratory,…
Relationship modeling of biomarkers in assessing the activity of ulcerative colitis
Prof. A.E. Dorofeyev, S.V.Golub*, O.E.Ananin*, Yu.Z.Dyni. National Medical Academy of Postgraduate Education named after P. L. Shupyk. *Cherkasy State Technological University. The article presents a study of the processes of information technology application of multi-level intelligent monitoring for non-invasive diagnosis of ulcerative colitis (UC) activity and assessment of the impact of biomarkers. Epidermal growth factor…
The first experience in the use of a circular cylinder in Ukraine for endoscopic radiofrequency ablation at Barrett›s esophagus
PhD, MD. V.A. Yakovenko. Medical center “Oberig” Universal hospital”, Kiev, Ukraine. State Scientific Institution «Scientific-practical center of prophylactic and clinical medicine» of Administrative Department, Kiev, Ukraine. National Medical University named after. O.O. Bogomolets Barrett’s esophagus is a potentially dangerous complication of GERD. Depending on the histological type of metastasis epithelium of the distal part of…
Optimization of the diagnostic search of patients with ulcerative colitis
PHD E.A.Kyrian. Ukrainian Medical Stomatological Academy, Poltava. This article presents a modern view of the genetic marker role in the progression of chronic ulcerative colitis, its course and complications. The influence of the single nucleotide polymorphism on the immune response and integrity of the intestine mucous membrane in patients with chronic ulcerative colitis was defined,…
Lessons of microbiota
Prof. Z.D. Semidotskaya, prof. T.D. Zvjagintseva*, PHD I.A. Chernyakova, PHD M.Yu. Neffa, A.E. Chernyakova. Kharkiv State Medical University *Kharkiv Medical Academy of Postgraduate Education. The article describes the current understanding of the role of the microbial community colonizing the human body (microbiota) in the functioning of all organs and systems of the host (macrobiont), in…
The role of melatonin in the development of functional disorders of the gastrointestinal tract
Prof. Zvyagintseva T.D., as. Gamanenko Ya.K. Kharkiv Medical Academy of Postgraduate Education. It has been established that in patients with functional diseases of the gastrointestinal tract (FD GIT) there are violations of neurohumoral regulation based on changes in the content of melatonin. The reduced level of melatonin in patients with functional diseases of the gastrointestinal…
Irritable bowel syndrome: modern concepts and new possibilities of correction
Prof. T.D. Zvyagintseva, PHD S.V. Gridneva. Kharkiv Medical Academy of Postgraduate Education. The article deals with the pathogenetic mechanisms of formation of irritable bowel syndrome (IBS) according to Roman criteria IV (2016), shows the main causes of abdominal pain in IBS — increase visceral sensitivity of the colon and disturbance of its motility, presents the…
The problem of constipation in general medical practice
PHD Kochuev GI, рrof Korzh AN, рrof Kochueva MN, Bereznyakov VI. Kharkiv Medical Academy of Postgraduate Education. The article presents data on the etiology, diagnosis and treatment of constipation in general medical practice. The main groups of laxatives and their rational use in the treatment of constipation are described. Key Words: constipation, pharmacotherapy of constipation,…
Correction of L-carnitine insufficiency in non-alcoholic steatohepatitis.
Prof. T.D. Zvyagintseva, PHD S.V. Glushchenko. Kharkiv Medical Academy of Postgraduate Education, Department of Gastroenterology. Objective: Improvement of the diagnosis of non-alcoholic steatohepatitis (NASH) and the development of optimally effective methods for correcting the revealed violations. Materials and Methods: examined 65 patients with verified NASH. The age of the patients ranged from 23 to 67…
Ultrasound examination of the gallbladder in normal and pathological conditions
Phatological state after cholecystectomy: from pathogenesis to treatment
Prof. Zvyagintseva T.D., as. prof. Shargorod I.I. Kharkiv Medical Academy of Postgraduate Education. Considered a pathological condition after cholecystectomy (biliary dysfunction, lesions esophagogastroduodenal zone halogena diarrhea, changes in the microbiome of the intestine). Their availability determines the therapeutic approach, the choice of pharmacotherapy, most adequately relieves the symptoms of these disorders. Key Words: cholecystectomy, postcholecystectomy…