Prof. Sergienko O.I., prof. Oparin A.G., assoc. prof. Novokhatnya А.E. Kharkiv National Medical University Department of therapy №2 Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver diseases: 25% of the population of European countries have signs of NAFLD, 10–20% of patients with steatosis develop an inflammatory process (non-alcoholic…
Gastroenterology
Metabolic-associated fatty liver disease and gut microbiota: pathogenetic relationships and therapeutic target
Prof. Zvyagintseva T.D., assoc. prof. Chernobay A.I. Kharkiv National Medical University The article presents the characteristics of metabolically associated fatty liver disease (МАFLD) in combination with intestinal microbiota. The risk factors for the development of МАFLD, the importance of the «microbiotaintestine-liver» axis in the progression of fatty liver disease and in the disruption of…
Gastroesophageal reflux disease: current insights into pathogenesis, diagnosis and treatment
PhD. Yarantseva N.А., assoc. prof. Oparina T.N., assoc. prof. Novokhatnya А.E. Kharkiv National Medical University Gastroesophageal reflux disease (GERD) affects millions of people worldwide with significant clinical consequences [1, 2]. GERD presents with recurrent and severe heartburn and regurgitation or GERD-specific complications and affects approximately 20% of the adult population in high-income countries [3, 4,…
Postcholecystectomy syndrome: a new look at the old problem and the possibilities of pathogenetic therapy
Prof. Zvyagintseva T.D., Assoc.prof. Chernobay A.I., as. Yaroshenko A.V., prof. Oparin A.G. Kharkiv National Medical University In the article, from the modern standpoint, the pathogenetic and clinical characteristics of PCS as a dysfunction of the sphincter of Oddi are given, the mechanisms for the development of this pathology, the principles of therapy with the inclusion…
Functional dyspepsia (according to the materials of the European guidelines)
Prof. Sergienko O.I., prof. Oparin O.A. Kharkiv National Medical University Functional dyspepsia (FD) is a common disorder of the interaction between the gastrointestinal tract and the brain, affecting approximately 7% of people in the community. In recent times, significant progress has been made in understanding the complex pathophysiology and new evidence has been obtained regarding…
Characteristics of psychosomatic disorders in patients with gastroesophageal reflux disease with concomitant obesity
Prof. Oparin O., Kashyrtseva O. Kharkiv Medical Academy of Postgraduate Education Purpose: To investigate the frequency and severity of psychosomatic disorders in patients with gastroesophageal reflux disease with comorbid obesity and patients with GERD without concomitant pathology, to evaluate the influence of psychoemotional state on the clinical picture of GERD. Materials and results. 90 patients…
Modern aspects of pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension in the presence or absence of сhronic kidney disease
Prof. K. Prosolenko, ass. К. Lapshyna, V. Ryabuha Kharkiv National Medical University. Government Institution “L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine” The article presents the main aspects of the pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension. These diseases are very often presented as comorbidities in…
The development of COPD in ulcerative colitis: clinical and instrumental confirmation
Prof. T.D. Zvyagintseva, A.V. Yaroshenko Kharkiv Medical Academy of Postgraduate Education Objective — to study the degree and frequency of lung damage in patients with UC. Materials and methods: A total of 24 patients with a verified diagnosis of UC were examined, 63.6% of them with left-sided intestinal lesions of moderate severity and 36.4% with…
Modern understanding of mucoviscidosis.
Prof. T.D. Zvyagintseva, as. Ya. K. Gamanenko. Kharkiv medical academy of postgraduation education Detailed description of difficulties which may appear in diagnostic of mucoviscidosis and the ways of their overcoming are reported. The diagnostic algorithms are presented. Principles of basic therapy and particularities of treatment of mucoviscidosis in different age groups are considered. Key words:…
Features of the quality of life in patients with a non-erosive form of gastroesophageal reflux disease with concomitant chronic obstructive pulmonary disease in young people.
Prof. A.G. Oparin, N.V. Semenova, PHD T.N. Oparina Kharkiv Medical Academy of Postgraduate Education Chronic obstructive pulmonary disease (COPD) is most commonly associated with gastroesophageal reflux disease (GERD). There are practically no studies of the quality of life in young patients. The aim of our study is to study the characteristics of the quality of…
The role of adipose tissue hormones in the formation and course of gastroesophageal reflux disease in combination with obesity.
Prof. O.A. Oparin, O.M. Malіar, PHD T.N. Oparina, E. J. Abakumova Kharkiv Medical Academy of Postgraduate Education Objective: To investigate the level of leptin in patients with gastroesophageal reflux disease with concomitant obesity and evaluate its effect on the course of the disease. Materials and results. The study involved 50 patients. The first group included…
Combined detection of inorganic syndromes of the gastrointestinal tract and their differential diagnosis.
R. I. Khalafova Polyclinic of the Higher Military School named after H.A. Aliyev To study the frequency of detection of combinations of the main syndromes of the gastrointestinal tract (GIT) and their differential diagnosis, consisting of irritable bowel syndrome (IBS), syndrome of functional dyspepsia (SFD), chronic idiopathic dyspepsia (CIT) and gastroesophageal reflux disease (GERD). The…
Features of the clinical course and motorsecretory disorders in gastroesophageal reflux disease in overweight patients.
Prof. Oparin O.A., Maliar O.M., Fedchenko Yu.G. Kharkiv Medical Academy of Postgraduate Education Objective: To study the mechanisms of motor-secretory disorders in young patients with gastroesophageal reflux disease with concomitant obesity. Materials and results. The study involved 55 patients. The first group included patients with GERD with concomitant obesity, the second group included patients with…
Issues of inflammatory bowel disease management in primary care
PHD M. Brynza, аs. K. Uvarova V. N. Karazin Kharkiv National University Іnflammatory bowel diseases are among various chronic processes, which, in the case of inadequate diagnosis and irrational treatment, eventually lead to highly unfavorable consequences. Thus, the timely establishment of the diagnosis, as well as the prescription of effective therapy and the subsequent careful…
Biological diagnosis of inflammatory bowel disease: current ideas and future achievements.
Prof. T.D. Zvyagintseva, A.V. Yaroshenko Kharkiv medical academy of postgraduation education Article presents review of new biological methods for the diagnosis of IBD. The problem of late diagnosis of IBD remains relevant because of increased frequency of adverse consequences of the disease by increasing the length of the period when patients do not receive adequate…
The importance of vaspin in external and internal secretory activity of the pancreas.
D. Pylov Kharkiv National Medical University, Department of Internal Medicine №3 and Endocrinology To analyze the data of the scientific literature on the importance of vaspin as a pathogenetic link in the development of insufficiency of exocrine function of the pancreas in type 2 diabetes patients in combination with chronic pancreatitis and. Literary sources were searched…
Helicobacter pylori in the clinic of internal medicine
Prof. T.D. Zvyagintseva, as. Ya. K. Gamanenko Kharkiv medical academy of postgraduation education The article is devoted to the analysis of the literature on the problem of the possible relationship of Helicobacter pylori in the pathogenesis of various extragastric pathologies – diabetes mellitus, metabolic syndrome, cardiovascular diseases and multiple sclerosis. It is possible that Helicobacter…
Biliary pancreatitis: reasons of development and going near treatment
Prof. T.D. Zvyagintseva, as. Ya. K. Gamanenko. Kharkiv Medical Academy of Postgraduate Education Biliary pathology is the most common cause of the development of acute and exacerbation of chronic pancreatitis. A feature of biliary pancreatitis, which distinguishes it from other forms of pancreatitis, is the combination of exocrine pancreatic insufficiency with chronic biliary insufficiency, which…
The role of melatonin in the complex treatment of patients with gastroesophageal reflux disease with sleep apnea syndrome
Prof. A.G. Oparin, M.A. Murghuzov Kharkiv Medical Academy of Postgraduate Education The study showed that the inclusion of melatonin in the standard treatment regimen for patients with GERD with concomitant obstructive sleep apnea syndrome is not only clinically justified, it also shortens the onset of clinical remission of both the main and concomitant pathologies, with…
Clinical-pathogenetic parallels in the combined course of autoimmune tyreoiditis and gastroesophageal reflux disease among young adults
N.A. Yarantseva Kharkіv Medical Academy of Postgraduate Education, Department of Therapy, Rheumatology and Clinical Pharmacology The purpose of this article is to study the general pathogenetic mechanisms and features of the clinical picture in the combined course of GERD and AIT. The autoimmune process leads to inflammation in the tissues of the thyroid gland its…