Kharkіv Medical Academy of Postgraduate Education, Department of Therapy, Rheumatology and Clinical Pharmacology
The purpose of this article is to study the general pathogenetic mechanisms and features of the clinical picture in the combined course of GERD and AIT. The autoimmune process leads to inflammation in the tissues of the thyroid gland its degeneration and further fibrosis. A decrease in the synthesis of thyroid hormones enhances the production of TSH, which according to the feedback principle provokes the growth of the thyroid epithelium. The presence of gastrointestinal effects in thyroid hormones suggests that the thyroid gland plays an important role in the development of gastrointestinal diseases. Thyroid hormones affect speed and intensity of the secretion of digestive glands as well as muscle tone, motor-evacuation function of the digestive tract and the speed of repair of damaged tissues.
- A clear correlation was established between a decrease in the motor-evacuation function of the stomach, an increase in the acidity of gastric juice, a decrease in thyroid hormones and an increase in TSH in the comorbid course of GERD and AIT in hypothyroidism;
- It was noted that patients with GERD with concomitant AIT compared with patients with isolated GERD had an increased level of anxiety, neurotism and a lower level of life quality;
- The data obtained indicate a direct effect of thyroid hormones on the pathogenetic links of GERD and the aggravation of the clinical picture in the combined course of GERD and AIT.
Key Words: gastroesophageal reflux disease, autoimmune thyroiditis, thyroid hormones.