Kharkiv Medical Akademy of Postgraduate Education
This article addresses the issue of the part of melatonin—serotonin system in the mechanisms of formation of insomnia with GERD accompanied by NCD. We conducted a study of four groups of patients suffering from GERD with insomnia and from GERD accompanied by NCD with insomnia. Two groups have got melatoninbased medication in addition to the standard therapy. We studied sleep quality using PSQI questionnaire, motor-secretory changes of esophagus and stomach, level of melatonin and serotonin in blood serum before and after the treatment. We found out that patients with GERD with insomnia and with GERD accompanied by NCD with insomnia have significant changes in the level of both melatonin and serotonin, whereas in patients with comorbid course these changes are more considerable. We established a correlation between noticeability of GERD clinical features, sleep quality, motor-secretory disorders, and level of melatonin and serotonin. Adding melatonin medication to the standard treatment scheme for patients suffering from GERD with insomnia and from GERD accompanied by NCD with insomnia facilitates significant improvement of sleep quality, motorsecretory indicators, and level of melatonin and serotonin in blood serum, as a result advancing remission.
Key Words: melatonin, serotonin, gastroesophageal reflux disease, insomnia, neurocirculatory dystonia.