The effect of adiponectin gene polymorphism on the severity of metabolic disorders and some liver parameters in patients with non-alcoholic fatty liver disease in combination with hypertension

K.О. Prosolenko

Kharkiv National Medical University.

The aim of the work was to study the relationship of the genetic polymorphism of the G276T marker of the ADIPOQ gene with the severity of metabolic disorders and changes in some liver indices with comorbidity of hypertension (Н) and non-alcoholic fatty liver disease (NAFLD).

The object of the study was 116 patients with comorbidity of NAFLD and stage II Н, 2 degrees. The average age of the patients was 49.11 ± 9.95 years. The control group consisted of 20 healthy individuals of the same age category of male and female. Blood biochemical parameters were determined according to standard methods and the contents were studied: aminotransferases, gamma-glutamyltranspeptidase, glucose, glycosylated hemoglobin, insulin, adiponectin. The HOMA index was also determined. Based on the polymer chain reaction data, the ADIPOQ genetic polymorphism was determined.

Three ADIPOQ genotypes (G/G, G/T and T/T) were identified by G276T polymorphism. According to our data, the presence of the T allele of the G276T polymorphic marker of the ADIPOQ gene is associated with the development of comorbidity of Н and NAFLD. In patients with comorbidity Н and NAFLD G/T or T/T genotypes, more pronounced disorders of carbohydrate and lipid metabolism are characteristic than with the G/G genotype. The T allele of the G276T polymorphic marker of the ADIPOQ gene is associated with the development of more significant liver damage in patients with comorbidity of Н and NAFLD, which is confirmed by significantly higher rates of hepatic cytolysis.

Key Words: non-alcoholic fatty liver disease, hypertension, adiponectin gene polymorphism, metabolic disorders, markers of liver damage.

https://dx.doi.org/10.15407/

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