Prof. O.M. Korzh, prof. L.V. Cherkashyna, assoc. prof. L.M. Tsogoeva Kharkiv National Medical University, Department of general practice-family medic Prediabetes is a common metabolic condition that often remains undiagnosed and significantly increases the risk of developing type 2 diabetes and cardiovascular complications. This article examines the role of the family physician in the early detection…
Endocrinology
Features of motor-secretory disorders and distribution of fat tissue in patients with gastroesophageal reflux disease with common obesity
Prof. O.A. Oparin, assoc. prof. Yu.G. Fedchenko, assoc. prof. A.V. Blagoveshchenska, assoc. prof. A.E. Novokhatnya, assist. O.M. Kashirttseva Kharkiv National Medical University Ukrainian Humanitarian Institute It has been established that patients with GERD with concomitant obesity have secretory disorders, and in patients with isolated GERD, increased gastric juice aggression comes to the fore, and in…
Features of the etiology and clinical course of nosocomial infections in diabetes (literature review)
Assoc. prof. I.I. Medvid, prof. L.S. Babinets, assoc. prof. I.I. Herasymets I. Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine Relevance. Diabetes mellitus affects approximately 12 % of the adult population and is a serious burden on the health care system. It affects about 463 million people worldwide. Patients with diabetes…
The influence of secretory activity of adipose tissue adipocytes on the development of gastroesophageal reflux disease
Prof. A.G. Oparin, assoc. prof. L.O. Khomenko, assist. I.P. Korenovsky, assoc. prof. T.M. Oparina, assoc. prof. Y.K. Sikalo. Kharkiv National Medical University Ukrainian Humanitarian Institute The article shows the role of adipose tissue and its hormones in the formation of the pathogenesis of gastroesophageal reflux disease. The role of the hormone leptin in these processes…
Therapeutic effect of peppermint oil application in patients with irritable bowel syndrome and metabolic syndrome
Prof. O.I. Sergienko, assoc. prof. A.I. Сhernobai, assoc. prof. A.Y. Novokhatnia, assoc. prof. A.V. Vlasenko, assoc. prof. Y.K. Sikalo Kharkiv National Medical University Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, affecting almost 20% of the population, causing significant functional and socioeconomic burden. An existing association between functional bowel disorders,…
Metabolic effects of vitamin D
Assoc. prof. I.P. Dunaieva, assoc. prof. O.L. Yakovenko, prof. N.O. Kravchun Kharkiv National Medical University The article is devoted to the analysis of the metabolic effects of vitamin D, its role in the prevention and treatment of diseases. The metabolism of vitamin D, the mechanisms of influence on various body systems, as well as the…
Arterial hypertension in obese patients: clinical and pathogenetic features
Prof. O.M. Korzh, prof. L.V. Cherkashyna, assoc. prof. L.M. Tsogoeva Kharkiv National Medical University Induced arterial hypertension (AH) is one of the forms of AH, the pathogenetic mechanisms of which are well studied: the main reason is the disruption of the functioning of visceral adipose tissue, which leads to activation of the renin-angiotensin-aldosterone system, imbalance…
Analysis of the relationship between the parameters of the autonomic nervous system and the clinical course of type 2 diabetes mellitus in combination with chronic pancreatitis
Prof. L. S. Babinets, asp. O. V. Redkva I.Ya. Horbachevsky Ternopil National Medical University Ministry of Health of Ukraine Abstract. Currently, the possible relationship between the function of the autonomic nervous system (ANS) and type 2 diabetes mellitus (T2DM) is being actively studied. ANS imbalance is also mentioned by researchers as one of the possible…
Construction of a prognotic model of GERD occurrence in overweight people
Prof. A.G. Oparin, assoc. prof. A.E. Novokhatnya, asst. O.M. Kashirttseva, assoc. prof. T.M. Oparina, asst. I.P. Korenovsky, asst. N.A. Yarantseva Kharkiv National Medical University Ukrainian Humanitarian Institute The article reliably recorded high chances of comorbid GERD with obesity with increased blood leptin content (OR = 3.51; 95.0% CI 1.62–612.5; p = 0.023), increased diameter of…
Clinical and anamnestic characteristics and analysis of risk factors of gastroesophageal reflux disease with concomitant obesity in young people
Prof. O.A. Oparin, prof. A.G. Oparin, assoc. prof. A.V. Blagoveshchenska, assoc. prof. Yu.G. Fedchenko, asst. O.M. Kashirttseva, assoc. prof. L.O. Khomenko Kharkiv National Medical University Ukrainian Humanitarian Institute The article analyzes clinical and anamnestic features of patients with gastroesophageal reflex disease with concomitant obesity in young people. Correlations between clinical manifestations and the presence of…
Pathophysiological and biochemical-molecular concepts of the comorbid course of gastroesophageal reflux disease and obesity in young people
Prof. A.G. Oparin, assoc. prof. Yu. G. Fedchenko, assoc. prof. A.V. Blagoveshchenska, assoc. prof. Khomenko, assoc. prof. A.E. Novohatnya, assoc. prof. T.M. Oparina, asp. O.M. Kashirtseva, asst. I.P. Korenovsky Kharkiv National Medical University The article analyzes the latest ideas about the pathogenetic mechanisms of the combined formation of gastroesophageal reflux disease and obesity in young…
To the problem of optimal antihypertensive therapy for patients with arterial hypertension and type 2 diabetes (according to the 2023 European Society of Hypertension Recommendations)
Ph.D. D.K. Miloslavsky, prof. S.M. Koval Government Institution «L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine», Kharkiv The review of the problem of optimal antihypertensive therapy for patients with arterial hypertension (AH) with type 2 diabetes mellitus (T2DM) through the prism of the 2023 European Society of Hypertension Guidelines…
Features of lipid and carbohydrate metabolism in patients with gastroesophageal reflux disease against type 2 diabetes, depending on the presence of obesity
Bondar-Кeleberda O.S. Kharkiv National Medical University The aim: To reveal the peculiarities of lipid and carbohydrate metabolism in patients with isolated gastroesophageal reflex disease (GERD), GERD on the background of type 2 diabetes mellitus (T2DM) and with type 2 DM, depending on the body mass index (BMI). Materials and methods. To participate in the study,…
Relationships between home blood pressure monitoring parameters and plasma catestatin and relaxin-2 levels in patients with essential hypertension and type 2 diabetes mellitus
Pankova O.A., prof. Korzh O.M. Kharkiv National Medical University Objective. To investigate the peculiarities of home blood pressure monitoring parameters in patients with essential hypertension (EH) in combination with type 2 diabetes mellitus (T2DM) and to evaluate their relationships with plasma catestatin (CTS) and relaxin-2 (RLN-2) levels. Materials and methods. 106 patients with EH, 55…
Features of arterial hypertension in obesity
Prof. Korzh O.M. Kharkiv National Medical University Hypertension in obesity is a fairly common problem, and it has its own characteristics. Obesity promotes inflammation in the body, which can damage blood vessels and lead to atherosclerosis, which also contributes to increased blood pressure. Obesity can lead to increased resistance to blood flow in vessels through…
Current concepts about influence of thyroid gland hormones on the development and course of gastro-esophageal reflux disease
Prof. Oparin O.A., prof. Oparin A.G., asst Yarantseva N.А., assoc. prof. Novokhatnya А.E., assoc. prof. Chomenko L.O., asst. Korenovskiy I.P. Kharkiv National Medical University The problem of gastroesophageal reflux disease (GERD) remains one of the most relevant in modern gastroenterology. In recent decades, there has been a tendency to increase in the incidence of GERD…
Сlinic and pathogenic significance of omentin
Prof. Korzh O.M., asst. Fylenko Y.M. Kharkiv National Medical University Today, adipokines are important cellular signaling proteins synthesized by adipose tissue and involved in a variety of processes, including inflammation, lipid and glucose metabolism, insulin sensitivity, endothelial cell function, angiogenesis, blood pressure regulation, and many others. This review examines the immunological and endocrine function of…
Comorbid patient: an interdisciplinary problem (literature review)
Prof. Kravchun N.O., assoc. prof. Dunaieva I.P., assoc. prof. Yakovenko O.L., prof. Kravchun P.P. Kharkiv National Medical University The comorbidity of arterial hypertension (AH), type 2 diabetes mellitus (T2DM), obesity leads to the early development of atherosclerotic lesions of coronary and cerebral vessels, which, in turn, significantly accelerates the occurrence of coronary arterial disease (CHD),…
Insulin resistance and cardiovascular diseases: focus on common in pathogenesis and treatment
Prof. Zhuravlyova L.V., asst. Rohachova T.A., assoc. prof. Sokolnikova N.V., assoc. prof. Yankevich O.O. Kharkiv National Medical University Department of Internal Medicine №3 and Endocrinology The prevalence of cardiovascular disease and type 2 diabetes has increased dramatically worldwide over the past 30 years. These diseases have become a worldwide epidemic and the main cause of…
Endotoxicosis and inflammation as predictors of the deepening of panсreatic functional insufficiency in chronic pancreatitis in combination with type 2 diabetes
Prof. Babinets L.S., asp. Zemlyak O.S., doctorant Halabitska I.M. I.Horbachevsky Ternopil National Medical University According to scientists, a significant role in the progression of chronic pancreatitis (CP) and diabetes mellitus (DM), as well as in the occurrence of complications of these diseases, is played by inflammation and endogenous intoxication by the products of protein breakdown…