The role of adipose tissue hormones in the formation and course of gastroesophageal reflux disease in combination with obesity.

Prof. O.A. Oparin, O.M. Malіar, PHD T.N. Oparina, E. J. Abakumova

Kharkiv Medical Academy of Postgraduate Education

Objective: To investigate the level of leptin in patients with gastroesophageal reflux disease with concomitant obesity and evaluate its effect on the course of the disease. Materials and results. The study involved 50 patients. The first group included patients with GERD with concomitant obesity, the second group — patients with GERD without concomitant pathology. A survey was conducted using the GERDQ questionnaire, which showed that patients with concomitant obesity were more likely to have symptoms of the disease. Leptin levels were determined by enzyme-linked immunosorbent assay. Іn subjects of group 1, the concentration of leptin will be significantly higher than in patients of group 2. An endoscopic study was performed, the results of which were compared with the concentration of leptin. There is a direct correlation between body mass index, the degree of esophageal damage and leptin levels.

Key Words: gastroesophageal reflux disease, GERD, obesity, leptin, adipokines.

https://dx.doi.org/10.15407/internalmed2021.02.096

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Cite:

  1. Опарін, О.А. Роль гормонів жирової тканини у формуванні та перебігу гастроезофагеальної рефлюксної хвороби у поєднанні з ожирінням / О.А. Опарін, О.М. Маляр, Т.Н. Опаріна, О. Я. Абакумова // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2021. – № 2. – С. 96-98. doi: 15407/internalmed2021.02.096
  2. Oparin OA, Malіar OM, Oparina TN, Abakumova EJ. Rol hormoniv zhyrovoi tkanyny u formuvanni ta perebihu hastroezofahealnoi refliuksnoi khvoroby u poiednanni z ozhyrinniam. [The role of adipose tissue hormones in the formation and course of gastroesophageal reflux disease in combination with obesity]. Shidnoevr. z. vnutr. simejnoi med. 2021;2:96-98. Ukrainian. doi: 10.15407/internalmed2021.02.096

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