Correction of L-carnitine insufficiency in non-alcoholic steatohepatitis.

Prof. T.D. Zvyagintseva, PHD S.V. Glushchenko.

Kharkiv Medical Academy of Postgraduate Education, Department of Gastroenterology.

Objective: Improvement of the diagnosis of non-alcoholic steatohepatitis (NASH) and the development of optimally effective methods for correcting the revealed violations.

Materials and Methods: examined 65 patients with verified NASH. The age of the patients ranged from 23 to 67 years. Among them were 36 (55.4%) women and 29 (44.6%) men. The control group consisted of 20 healthy individuals. The effectiveness of complex therapy with the inclusion of the drug «Hepadif» was studied.

Results: The presence of carnitine insufficiency, hyperhomocysteinemia, increase in the level of proinflammatory cytokines in all patients with NASH. After a month of treatment with complex therapy, the level of L-carnitine increased from 14.5 (13.1, 15.7) μmol/l to 31.1 (28.8, 34.1) μmol/l (p<0.001), homocysteine decreased to subnormal figures – 11.8 (11.0, 12.8) μmol/l (p<0.001). When studying the cytokine profile in the group after treatment, a significant decrease in the level of proinflammatory cytokines was revealed.

Conclusion: The use of complex therapy with the inclusion of drugs «Hepadif» has a positive effect on the clinical course of the disease, contributes to the elimination of L-carnitine deficiency, hyperhomocysteinemia, a decrease in the level of pro-inflammatory cytokines.

Key Words: non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, L-carnitine, homocysteine, hyperhomocysteinemia.
Zvyagintseva TD, Glushchenko SV. [Correction of L-carnitine insufficiency in non-alcoholic steatohepatitis]. Shidnoevr. z. vnutr. simejnoi med. 2018;1:16-21. Russian.


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