Еrosive and non-erosive forms of gastroesophageal reflux disease

Prof. T.D. Zvyagintseva , as.prof. Ya.K. Gamanenko 

Kharkiv Academy of Postgraduate Medicine

The article deals with the issues of modern understanding of cellular and molecular mechanisms of the pathogenesis of GERD-associated inflammation of the esophagus mucosa involves complex and multifactorial immune-mediated effects of re-action of gastric reflux contents with varying pH values. Until recently, the change in the daily pH-metric index in the acid side was clearly associated with the presence of reflux esophagitis. However, it has appeared that the association of acid action and the manifestation of symptoms in patients isot always reliable. Currently, the available spectrum of studies allows the isolation of individual phenotypes of GERD and NERD and to determine the optimal therapies based on additional methods of research and evaluation of the impedance of the esophagus mucosa, manometry, histopathological methods and psychometry. Extensions of ideas about the mechanisms of formation and progress of GERD puts certain tasks in the allocation of the most reliable methods of diagnosis of the disease, which in the next will determine the mostrational approaches to the treatment of patients and prevention of the development of such complications of GERD as erosion esophagitis, Barrett’s esophagus and adenocarcinoma of the esophagus.

Key Words: gastroesophageal reflux disease, non-erosive reflux disease, Barrett’s esophagus, Н.pylori, protonpump inhibitors, esophagogastroscopy.



For citing:

  1. Звягінцева, Т.Д. Ерозивна та неерозивна гастроезофагеальна рефлюксна хвороба: сучасні тенденції в діагностиці та лікуванні / Т.Д. Звягінцева, Я.К. Гаманенко // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2019. – № 2. – С. 42-49. doi: 10.15407/internalmed2019.02.042
  2. Zvyagintseva TD, Gamanenko YaK. [Erosive And Non-Erosive Forms Of Gastroesophageal Reflux Disease]. Shidnoevr. z. vnutr. simejnoi med. 2019;2:42-49. doi: 10.15407/internalmed2019.02.042. Ukrainian.