Characteristics of motor-secretory disorders in patients with ischemicheart disease with concomitant gastroesophageal reflux disease A.S Vnukova

Kharkiv medical academy of postgraduate education

The goal of the study was to examine the characteristics of motor-secretory disorders in patients with ischemicheart disease (IHD) and gastroesophageal reflux disease (GERD).

The present study was conducted with a total of 110 patients. The first group included 66 patients with IHD and concomitant GERD. The second group included 44 patients with IHD and without concomitant pathology.Control group included 20 healthy participants. Ultrasound examination was performed to assess motorevacuatorychanges. Gastric secretory function was assessed by endogastric pH-metry. The state of the regionalblood circulation was assessed by the measurement of celiac trunk diameter and blood flow velocity. Theseparameters were determined using sonography with color Doppler mapping.

After assessing ultrasound results in group 1 patients we found a significant increase in diameter of esophagealhiatus diameter, dilation of lower third of esophagus. Gastric juice aggression was found in both groups, morepronounced in group 1 patients. Decrease in celiac trunk diameter and blood flow velocity measurements werefound in both study groups.During the study a clear correlational dependence between increase in esophageal hiatus diameter, dilation ofthe lower third of esophagus, measurements of gastric juice pH and regional blood flow velocity were establishedboth in IHD patients with concomitant GERD and IHD patients without concomitant pathology.

Key Words: motor-secretory disorders, ischemic heart disease, gastroesophageal reflux disease, celiac trunk, regional blood flow, pH-metry


For citing:

  1. Внукова, А.С. Особливості моторно-секреторних порушень у хворих на ішемічну хворобу серця із супутньою гастроезофагеальною рефлюксною хворобою // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2019. – № 2. – С. 72-75. doi: 10.15407/internalmed2019.02.072
  2. Vnukova AS. [Characteristics Of Motor-Secretory Disorders In Patients With Ischemic Heart Disease With Concomitant Gastroesophageal Reflux Disease]. Shidnoevr. z. vnutr. simejnoi med. 2019;2:72-75. doi: 10.15407/internalmed2019.02.072. Ukrainian.


1. Oparin A, Vnukova A. The Role of Endothelial Dysfunction in the Mechanism of Gastroesophageal Reflux Disease Development in Patients with Ischemic Heart Disease. Acta clinica Croatica. 2017; 56(4):635-639.

2. Tabakaev MV, Artamonova GV. Urbanization and cardiovascular diseases in modern society. Russ J Cardiol. 2015; 6 (122): 94-99.

3. Morozov SV, Kucherjavij JuA. Gastrojezofageal’naja refljuksnaja bolezn’: formy zabolevanija i osobennosti ih lechenija. Lechebnoe delo. 2015; 4: 21-29. Russian.

4. Vanhoutte PM, Shimokawa H, Feletou M, Tang E.H.C. Endothelial dysfunction and vascular disease-a 30th anniversary update. Acta Physiologica. 2017; 1 (219): 22-96.

5. Khukhlina OS, Drozd VYu, Antoniv AA, Kopchuk TH, Kotsiubiichuk Zia. Pathogenetic role of nitrogen monoxide efficiency of pharmacotherapy in patients with gastroesophageal reflux disease and stable angina of tension. Wiadomosci lekarskie; 2019; 72 (5 cz 1):753-756.

6. Katz PO, Gerson LB, Vela MF. Diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013; 108:308-28. doi: 10.1038/ajg.2012.444

7. Kwok CS, Jeevanantham V, Dawn B, Loke YK. No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: meta-analysis. Int J Cardiol. 2013;167(3):965-74. doi: 10.1016/j.ijcard.2012.03.085

8. Khomenko L, Vnukova A, Dvoiashkina Y. Features Of Endothelial Dysfunction In Elderly Persons With Coronary Heart Disease And Concomitant Gastroesophageal Reflux Disease. Georgian medical news. 2019; 287:78-82.

9. Oparin AA, Lavrova NV, Kornienko DA. Features of Motility and Secretory Disorders in Different Forms of Gastroesophageal Reflux Disease. Visnyk problem biologhiji i medycyny. 2013; 3:131-133. Russian.

10. Stable ischemic heart disease [ Internet] Unified clinical protocol of primary, secondary (specialized) and tertiary (high-specialized) medical assistance. Order of the Ministry of Health of Ukraine № 152 – 2016 March. 2. Kiyv: Ministry of Health of Ukraine; 2016

11. Task Force Members, Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013 Oct;34(38):2949-3003. doi: 10.1093/eurheartj/eht296. PubMed PMID: 23996286.

12. Meyer A, Weithaeuser A, Steffens D, Bobbert P, Hassanein A, Ayral Y, Schultheiss HP, Rauch U. Inhibition of platelet function with clopidogrel is associated with a reduction of inflammation in patients with peripheral artery disease. Cardiovasc Revasc Med. 2016 Apr-May;17(3):169-75 doi: 10.1016/j.carrev.2016.01.010. PubMed PMID: 27157293

13. Vakil N, Van Zanten SV, Kahrilas P, Dent J, Jones R. The Montreal Definition and Classification of GERD. Am J Gastroenterol. 2006; 101 (8):1900-20. doi: 10.1111/j.1572-0241.2006.00630.x. PubMed PMID 16928254.