The role of endothelin-1 and melatonin in the mechanisms of the comorbid course of gastroesophageal reflux disease and obstructive sleep apnea syndrome

Prof. A.G. Oparin, M.A. Murghuzov

Kharkiv Medical Academy of Postgraduate Education

As revealed in studies in young patients with GERD, there is a statistically significant decrease in the level of melatonin metabolite (6-COM) and a statistically significant increase in the content of endothelin-1 compared with a group of healthy individuals of the same age and gender. Оbserved that the most pronounced imbalance between a statistically significant decrease in melatonin level and a statistically significant increase in ET- 1 content is observed in patients with GERD with concomitant sleep disturbance syndrome, not only in comparison with the norm, but also in the parameters of the group of patients with GERD without a combined pathology and at the same time, with the development of an imbalance in the melatonin / endothelin-1 system in patients with GERD without a combined pathology, and especially in the group of patients with GERD with concomitant apnea syndrome, a statistically significant decrease in QOL indicators is observed compared with the group of healthy students, manifesting in patients with GERD without a combined pathologies with a large degree of decrease in physical health tests, and in patients with GERD with concomitant pathology in the spectrum of mental health tests.

Key Words: gastroesophageal reflux disease, obstructive sleep apnea syndrome, melatonin, endothelin-1.

https://dx.doi.org/10.15407/internalmed2019.02.112

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For citing:

  1. Опарин, А.Г. Роль эндотелина-1 и мелатонина в механизмах коморбидного течения гастроэзофагеальной рефлюксной болезни и синдрома обструктивного апноэ сна / А.Г. Опарин, М.А. Мургузов // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2019. – № 2. – С. 112-116. doi: 10.15407/internalmed2019.02.112
  2. Oparin AG, Murghuzov MA. [The role of endothelin-1 and melatonin in the mechanisms of the comorbid course of gastroesophageal reflux disease and obstructive sleep apnea syndrome]. Shidnoevr. z. vnutr. simejnoi med. 2019;2:112-116. doi: 10.15407/internalmed2019.02.112. Russian.

References:

1. Komarov FI, Rapoport SI, Malinovskaja NK, Anisimov VI. Melatonin v norme i patologii. Moscow (Russia): medicina; 2004. 307 р. Russian.

2. Lazebnik LB. Gastrojezofageal’naja refljuksnaja bolezn’. Moscow (Russia): Medpraktika; 2012. 355 р. Russian.

3. Maev IV. Gastrojezofageal’naja refljuksnaja bolezn’ -lider kislotozavisimoj patologii verhnih otdelov zheludochno-kishechnogo trakta. Consilium Medicum. Gastrojenterologija. 2012;1:18-24. Russian.

4. Malaja LT, Korzh AN, Belkovaja LB. Jendotelial’naja disfunkcija. Har’kov: Torsing; 2000. 354 р. Russian.

5. Mel’nik SM, Lopatin AS, Latysheva EN. Osobennosti techenija faringolaringeal’noj i gastrojezofageal’noj refljuksnoj bolezni u pacientov s sindromom obstruktivnogo apnoje sna. Farmateka. 2016;10:62-66. Russian.

6. Fadeenko GD, Gridnev AE. Gastrojezofageal’naja refljuksnaja bolezn’: pishhevodnye i vnepishhevodnye projavlenija i komorbidnost’. Kyiv; 2014. 367 р. Russian.

7. Fedorova SO, Kozlova NM, Larik SJ. Sindrom obstruktivnogo apnoje sna, associirovannyj s gastrojezofageal’noj refljuksnoj bolezn’ju. Sibirskij medicinskij zhurnal. 2016;3:5-8. Russian.

8. Shelkovich JJ. Rol’ E-kadgerina v ocenke povrezhdenija slizistoj obolochki pishhevoda u pacientov s GJeRB, associirovannoj s sindromom obstruktivnogo apnoje/gipopnoje sna. Ros. zhur. gastrojent., gepatol., koloproktol. 2019;29(3):25-32. Russian.

9. Sherbyna MB, Shevchenko TM, Ghladun VM. Suchasna diaghnostyka ghastroэzofaghealjnoi refljuksnoi khvoroby; realjni dosjaghnennja ta perspektyvy. Patologhyja. 2018;15(3):396-404. Ukrainian.

10. Bubenik G. Thirty four years since the discovery of gastrointestinal melatonin. Journal of Physiology and Pharmacology. 2008:59(2):33-51.

11. Eusebi LH, Ratnakumaran R, Yuan Y, Solaymani-Dodaran M, Bazzoli F, C Ford A. Global prevalence and risk factors for, gastroesophageal reflux symptoms: a metaanalisis. Gut. 2018;67(3):430-440. doi: 10.1136/gutjnl-2016-313589.
https://doi.org/10.1136/gutjnl-2016-313589

12. Zerbib F, Mion F, J P M Smout A, Vaezi M, Sifrim D, Fox MR, Vela MF, Tutuian R, Tack J, Bredenoord AJ, Pandolfino J, Roman S. Modern diagnosis of GERD; the Lyon Consensus. Gut Published online Furst. 2018;67(7):1351-1362. doi: 10.1136/gutjnl-2017-314722.
https://doi.org/10.1136/gutjnl-2017-314722

13. Hasegawa K, Sato S, Tanimura K, Fuseya Y, Uemasu K, Hamakawa Y, Sato A, Mishima M, Muro S, Hirai T. Gastroesophageal reflux symptoms and nasal pulmonary disease. Respiratory Investigation. 2018;56(3):230-237. doi: 10.1016/j.resinv.2018.01.001.
https://doi.org/10.1016/j.resinv.2018.01.001

14. Lindam A, Ness-Jensen K, Jansson C, Nordenstedt H, Akerstedt T, Åkerstedt T, Hveem K, Lagergren J. Gastroesophageal reflux and sleep disturbances: a bidirectional association in population – based cohort study. The HUNT Study. Sleep. 2016;39(7):1421-7. doi: 10.5665/sleep.5976.
https://doi.org/10.5665/sleep.5976

15. Richter JE, Rubenstein JH. Presentation and Epidemiology of Gastroesophageal Reflux Disease. Gastroenterology. 2018;154(2):267-276. doi: 10.1053/j.gastro.2017.07.045.
https://doi.org/10.1053/j.gastro.2017.07.045

16. Tufic S, Stantos-Siva R, Taddei JH, Azeredo Bittencourt LR. Obstructive Sleep Study. Sleep Medicine. 2010;11(5):441-446. doi: 1016/S 1389 – 9457(09)70043-7.
https://doi.org/10.1016/j.sleep.2009.10.005

17. Wu Zn, Xang XP, Niu X, Xiao XY, Chen X. The relationship between obstructive sleep apnea hypopnea syndrome and gastroesophageal reflux disease: a meta-analysis. Sleep Breath. 2018;23:389-397. doi: 10.1007/s11325-018-1691-x.
https://doi.org/10.1007/s11325-018-1691-x

18. Zacharakis G, Alharbi MH, Alsalmi MM, et al. Prevalence of Gastroesophageal Reflux Disease Symptoms in Saudi Arabia. Int.J.Med.Res.Prof. 2018;4(1):21-27. URL. http./admin.ijmrp.com/Upload/vo14issue1/ 6%201JMRP%204(1)%2021-27.pdt (access date: 11.02.2019)

19. Fadeenko GD, Krahmalova EO, Izmajlova EV. Serce і sudini. 2016;2:38-43. Russian.