The role of endothelin-1 and melatonin in the mechanisms of the comorbid course of gastroesophageal reflux disease and obstructive sleep apnea syndrome

Prof. A.G. Oparin, M.A. Murghuzov

Kharkiv Medical Academy of Postgraduate Education

As revealed in studies in young patients with GERD, there is a statistically significant decrease in the level of melatonin metabolite (6-COM) and a statistically significant increase in the content of endothelin-1 compared with a group of healthy individuals of the same age and gender. Оbserved that the most pronounced imbalance between a statistically significant decrease in melatonin level and a statistically significant increase in ET- 1 content is observed in patients with GERD with concomitant sleep disturbance syndrome, not only in comparison with the norm, but also in the parameters of the group of patients with GERD without a combined pathology and at the same time, with the development of an imbalance in the melatonin / endothelin-1 system in patients with GERD without a combined pathology, and especially in the group of patients with GERD with concomitant apnea syndrome, a statistically significant decrease in QOL indicators is observed compared with the group of healthy students, manifesting in patients with GERD without a combined pathologies with a large degree of decrease in physical health tests, and in patients with GERD with concomitant pathology in the spectrum of mental health tests.

Key Words: gastroesophageal reflux disease, obstructive sleep apnea syndrome, melatonin, endothelin-1.

https://dx.doi.org/10.15407/internalmed2019.02.112

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For citing:

  1. Опарин, А.Г. Роль эндотелина-1 и мелатонина в механизмах коморбидного течения гастроэзофагеальной рефлюксной болезни и синдрома обструктивного апноэ сна / А.Г. Опарин, М.А. Мургузов // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2019. – № 2. – С. 112-116. doi: 10.15407/internalmed2019.02.112
  2. Oparin AG, Murghuzov MA. [The role of endothelin-1 and melatonin in the mechanisms of the comorbid course of gastroesophageal reflux disease and obstructive sleep apnea syndrome]. Shidnoevr. z. vnutr. simejnoi med. 2019;2:112-116. doi: 10.15407/internalmed2019.02.112. Russian.