Evolution of approaches to the treatment of acute coronary syndromes: from Eisenhower’s heart attack to modern approaches to treatment

Prof. Korzh O.M. Kharkiv Medical Academy of Postgraduate Education US President Dwight Eisenhower suffered an acute myocardial infarction in 1955. But in Eisenhower’s case, the beginning was unusual. Furthermore, ECGs were not widely available, cardiac enzymes were not used as diagnostic tests, and echocardiography or coronary angiography were not available to emergency physicians or cardiologists….

Diabetic dyslipidemia: focus on pathogenesis and treatment

Prof. Zhuravlyova L.V., PHD Sokolnikova N.V., PHD Rogachova T.A. Kharkiv National Medical University Atherosclerotic cardiovascular diseases are the most common cause of death in the developed countries of the world. Patients with diabetes mellitus 2 type are 2-4 times more likely to die from these diseases compared to patients without diabetes. This review discusses the…

The potential of catestatin in the diagnostics of cardiovascular diseases: current data and perspectives

Pankova O. Kharkiv medical academy of postgraduation education Cardiovascular diseases are not only the most common non-communicable diseases, but also occupy the leading place in the structure of total mortality in the world population. Among the wide range of pathogenetic mechanisms of the above-mentioned pathology, an increase in the activity of the sympathetic nervous system…

Cardiomyopathy. Clinic. Diagnostics. Treatment

Assoc. prof. Dvyashkina Yu.I., assoc. prof. Khomenko L. O., Oparina T.N. Kharkiv Medical Academy of Postgraduate Education The article provides modern information about cardiomyopathy: classification, features of the clinical picture, diagnosis depending on the form of cardiomyopathy. Particular attention is paid to the treatment and prevention of this pathology. Key Words: dilated cardiomyopathy, hypertrophic cardiomyopathy,…

Modern concepts on the pathogenesis and treatment of chronic heart failure: focus on the metabolic syndrome and its consequences

Prof. L.V. Zhuravlyova, PHD N.V. Sokolnikova, PHD T.A. Rogachova Kharkiv national medical university In recent decades, there has been a steady increase in the prevalence of chronic heart failure worldwide, which is estimated to affect up to 2% of the adult population and up to 10% of the elderly. The pathogenesis of chronic heart failure…

Modern approaches to the treatment of atrial firillation in patients with diabetes mellitus

S.A. Serik, V.I. Strona National Institute of Therapy L.T. Malaya NAMS of Ukraine, Kharkiv, Ukraine The article analyzes the main clinical and theoretical data on the features of the treatment of atrial fibrillation (AF) in combination with diabetes mellitus (DM). Differentiated approaches to the correction of these cardiac arrhythmias in this category of patients are…

Myocarditis associated with COVID-19 infection

Prof.  Isayeva G. S. Government Institution “L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine”  The article summarizes current data on the problem of myocarditis in patients with COVID-19 infection. Features of pathogenesis, risk factors, features of clinical manifestations and treatment of myocarditis are highlighted. Special attention is paid to…

Modern aspects of pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension in the presence or absence of сhronic kidney disease

Prof. K. Prosolenko, ass. К. Lapshyna, V. Ryabuha   Kharkiv National Medical University.  Government Institution “L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine”  The article presents the main aspects of the pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension. These diseases are very often presented as comorbidities in…

The application of quercetin in liposomal form for optimization of metabolic therapy of coronary artery disease.

Prof. O.M. Korzh Kharkiv Medical Academy of Postgraduate Education, Department of General Practice — Family Medicine The study of the clinical efficacy and safety of the dietary supplement L-Quercet as part of the complex therapy of patients with coronary artery disease with stable angina of II functional class, taking into account their effect on the…

Atrial fibrillation in diabetic patients.

Prof. S.A. Serik, PHD V.I. Strona National Institute of Therapy. L.T. Malaya NAMS of Ukraine, Kharkiv The article summarizes the main clinical and theoretical data on features of atrial fibrillation (AF) course in combination with diabetes mellitus (DM). The potential relationship between these comorbid conditions is analyzed on the basis of the results of epidemiological…

The relationship between diabetes mellitus and heart rhythm disorders: a focus on common pathophysiological mechanisms and modern treatment strategies.

Prof. Zhuravlyova L.V., PHD Sokolnikova N.V., PHD Rogachova T.A.  Kharkiv National Medical University The aim of this review article is the analysis the latest evidence based scientific data on the pathophysiological association between diabetes mellitus and heart arrhythmias and the most acceptable treatment possibilities for their correction. In recent decades, the worldwide prevalence of diabetes…

Optimization of the diagnosis of preclinical renal dysfunction in arterial hypertension and its combination with type 2 diabetes mellitus.

Hajibabirova Lala Mehman Scientific Research Institute of Cardiology named after J. Abdullayev, Baku. In order to optimize the diagnosis of early renal dysfunction in patients with arterial hypertension and its combination with type 2 diabetes mellitus, we examined 100 patients aged 35 to 58 years (mean age 46.8 ± 0.68). The first group included 50…

Levels of fibroblast growth factor and sulfated glycosoaminoglycans in connective tissue metabolism in patients with mitral valve prolapse and type 1 diabetes mellitus.

O.Ye. Nikolenko,  S.B. Pavlov*, O.M. Korzh* V.N.Karazin Kharkiv National University, Ukraine. *Kharkiv Medical Academy of Postgraduate Education, Ukraine In order to study the influence of the main fibroblast growth factor on the indicators of the state of the main substance of the extracellular matrix, a comparative analysis of their levels in the blood serum was…

Carvedilol versus metoprolol succinate in the treatment of patients with heart failure with reduced ejection fraction and patients with acute myocardial infarction

Prof. E.Ya. Nikolenko, PHD K.V. Vovk, ass. professor E.L. Pavlova, ass. professor O.A. Salun V.N. V.N. Karazin Kharkiv National University Department of General Practice-Family Medicine, Faculty of Medicine Choosing the best drug for the treatment of cardiac patients remains one of the most important aspects of medical practice. The purpose of this review is to…

Damage to the cardiovascular system in COVID-19

Prof. O.M. Korzh Kharkiv Medical Academy of Postgraduate Education COVID-19 affects not only the respiratory system, but also the cardiovascular system. The damage to the cardiovascular system in COVID-19 is multifactorial and several mechanisms are involved, including direct invasion, inflammation, thrombosis, autoantibody synthesis, and oxygen imbalance. The inflammation causes the release of cytokines, especially interleukin-6,…

Heart failure: historical aspects of the investigation.

Prof.Korzh О.М. Kharkiv Medical Academy of Postgraduate Education The history of the issue of heart failure goes back many millennia. Thus, indirect evidence of the attentive attitude of ancient doctors is associated with Hippocrates, who described such phenomena as edema of the extremities and the accumulation of fluid in the cavities, changes in the characteristics…

Clinical epidemiology of connective tissue dysplasia (CTD) in the student population. Mitral valve prolapse and phenotype of CTD.

As. O. Е. Nikolenko. V.N. Karazin Kharkiv National University, Ukraine. CTD and mitral valve prolapse are one of the most common cardiological pathologies among young people. The course and prognosis depend on the frequency of occurrence, severity, multifactorial effects on body organs and systems. Clinical and epidemiological methods establish the prevalence of phenotypic signs of…

Adipokines and cardiovascular diseases: clinical and therapeutic value.

Prof. О.М. Korzh, Y.N. Fylenko.  Kharkiv Medical Academy of Postgraduate Education. The article considers the pathogenesis of hypertension and the background of adipokine imbalance. Adipokines are directly involved in the mechanisms of blood pressure, atherogenesis, regulation of oxidative stress, blood clotting and the development of non-infectious inflammation. Despite the wide range of antihypertensive drugs on…

The effect of adiponectin gene polymorphism on the severity of metabolic disorders and some liver parameters in patients with non-alcoholic fatty liver disease in combination with hypertension

K.О. Prosolenko Kharkiv National Medical University. The aim of the work was to study the relationship of the genetic polymorphism of the G276T marker of the ADIPOQ gene with the severity of metabolic disorders and changes in some liver indices with comorbidity of hypertension (Н) and non-alcoholic fatty liver disease (NAFLD). The object of the…