Modern concepts on the pathogenesis and treatment of chronic heart failure: focus on the metabolic syndrome and its consequences

Prof. L.V. Zhuravlyova, PHD N.V. Sokolnikova, PHD T.A. Rogachova Kharkiv national medical university In recent decades, there has been a steady increase in the prevalence of chronic heart failure worldwide, which is estimated to affect up to 2% of the adult population and up to 10% of the elderly. The pathogenesis of chronic heart failure…

Modern approaches to the treatment of atrial firillation in patients with diabetes mellitus

S.A. Serik, V.I. Strona National Institute of Therapy L.T. Malaya NAMS of Ukraine, Kharkiv, Ukraine The article analyzes the main clinical and theoretical data on the features of the treatment of atrial fibrillation (AF) in combination with diabetes mellitus (DM). Differentiated approaches to the correction of these cardiac arrhythmias in this category of patients are…

Myocarditis associated with COVID-19 infection

Prof.  Isayeva G. S. Government Institution “L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine”  The article summarizes current data on the problem of myocarditis in patients with COVID-19 infection. Features of pathogenesis, risk factors, features of clinical manifestations and treatment of myocarditis are highlighted. Special attention is paid to…

Modern aspects of pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension in the presence or absence of сhronic kidney disease

Prof. K. Prosolenko, ass. К. Lapshyna, V. Ryabuha   Kharkiv National Medical University.  Government Institution “L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine”  The article presents the main aspects of the pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension. These diseases are very often presented as comorbidities in…

The application of quercetin in liposomal form for optimization of metabolic therapy of coronary artery disease.

Prof. O.M. Korzh Kharkiv Medical Academy of Postgraduate Education, Department of General Practice — Family Medicine The study of the clinical efficacy and safety of the dietary supplement L-Quercet as part of the complex therapy of patients with coronary artery disease with stable angina of II functional class, taking into account their effect on the…

Atrial fibrillation in diabetic patients.

Prof. S.A. Serik, PHD V.I. Strona National Institute of Therapy. L.T. Malaya NAMS of Ukraine, Kharkiv The article summarizes the main clinical and theoretical data on features of atrial fibrillation (AF) course in combination with diabetes mellitus (DM). The potential relationship between these comorbid conditions is analyzed on the basis of the results of epidemiological…

The relationship between diabetes mellitus and heart rhythm disorders: a focus on common pathophysiological mechanisms and modern treatment strategies.

Prof. Zhuravlyova L.V., PHD Sokolnikova N.V., PHD Rogachova T.A.  Kharkiv National Medical University The aim of this review article is the analysis the latest evidence based scientific data on the pathophysiological association between diabetes mellitus and heart arrhythmias and the most acceptable treatment possibilities for their correction. In recent decades, the worldwide prevalence of diabetes…

Optimization of the diagnosis of preclinical renal dysfunction in arterial hypertension and its combination with type 2 diabetes mellitus.

Hajibabirova Lala Mehman Scientific Research Institute of Cardiology named after J. Abdullayev, Baku. In order to optimize the diagnosis of early renal dysfunction in patients with arterial hypertension and its combination with type 2 diabetes mellitus, we examined 100 patients aged 35 to 58 years (mean age 46.8 ± 0.68). The first group included 50…

Levels of fibroblast growth factor and sulfated glycosoaminoglycans in connective tissue metabolism in patients with mitral valve prolapse and type 1 diabetes mellitus.

O.Ye. Nikolenko,  S.B. Pavlov*, O.M. Korzh* V.N.Karazin Kharkiv National University, Ukraine. *Kharkiv Medical Academy of Postgraduate Education, Ukraine In order to study the influence of the main fibroblast growth factor on the indicators of the state of the main substance of the extracellular matrix, a comparative analysis of their levels in the blood serum was…

Carvedilol versus metoprolol succinate in the treatment of patients with heart failure with reduced ejection fraction and patients with acute myocardial infarction

Prof. E.Ya. Nikolenko, PHD K.V. Vovk, ass. professor E.L. Pavlova, ass. professor O.A. Salun V.N. V.N. Karazin Kharkiv National University Department of General Practice-Family Medicine, Faculty of Medicine Choosing the best drug for the treatment of cardiac patients remains one of the most important aspects of medical practice. The purpose of this review is to…

Damage to the cardiovascular system in COVID-19

Prof. O.M. Korzh Kharkiv Medical Academy of Postgraduate Education COVID-19 affects not only the respiratory system, but also the cardiovascular system. The damage to the cardiovascular system in COVID-19 is multifactorial and several mechanisms are involved, including direct invasion, inflammation, thrombosis, autoantibody synthesis, and oxygen imbalance. The inflammation causes the release of cytokines, especially interleukin-6,…

Heart failure: historical aspects of the investigation.

Prof.Korzh О.М. Kharkiv Medical Academy of Postgraduate Education The history of the issue of heart failure goes back many millennia. Thus, indirect evidence of the attentive attitude of ancient doctors is associated with Hippocrates, who described such phenomena as edema of the extremities and the accumulation of fluid in the cavities, changes in the characteristics…

Clinical epidemiology of connective tissue dysplasia (CTD) in the student population. Mitral valve prolapse and phenotype of CTD.

As. O. Е. Nikolenko. V.N. Karazin Kharkiv National University, Ukraine. CTD and mitral valve prolapse are one of the most common cardiological pathologies among young people. The course and prognosis depend on the frequency of occurrence, severity, multifactorial effects on body organs and systems. Clinical and epidemiological methods establish the prevalence of phenotypic signs of…

Adipokines and cardiovascular diseases: clinical and therapeutic value.

Prof. О.М. Korzh, Y.N. Fylenko.  Kharkiv Medical Academy of Postgraduate Education. The article considers the pathogenesis of hypertension and the background of adipokine imbalance. Adipokines are directly involved in the mechanisms of blood pressure, atherogenesis, regulation of oxidative stress, blood clotting and the development of non-infectious inflammation. Despite the wide range of antihypertensive drugs on…

The effect of adiponectin gene polymorphism on the severity of metabolic disorders and some liver parameters in patients with non-alcoholic fatty liver disease in combination with hypertension

K.О. Prosolenko Kharkiv National Medical University. The aim of the work was to study the relationship of the genetic polymorphism of the G276T marker of the ADIPOQ gene with the severity of metabolic disorders and changes in some liver indices with comorbidity of hypertension (Н) and non-alcoholic fatty liver disease (NAFLD). The object of the…

Biomarker of systemic inflammation in women with arterial hypertension and obesity, depending on the presence of type 2 diabetes.

PHD N.M. Kyrychenko Sumy State University Type 2 diabetes mellitus and related complications are serious global public health problem. The presence of chronic systemic inflammation associated with an increase body weight and changes in the functions and activity of adipose tissue can cause the development of disorders in the regulation of glucose metabolism and in…

Heart failure in patients with diabetic cardiomyopathy: modern methods of treatment

Prof. L.V. Zhuravlyova, N.V. Sokolnikova, T.A. Rogachova Kharkiv National Medical University  Currently, all over the world, type 2 diabetes mellitus and the heart failure are developing into an epidemic. For the first time, diabetic cardiomyopathy as an independent diagnostic unit was described in 1972 by Shirley Rubler and colleagues. Currently, the most common phenotype of…

Myocardial muscle coronary arteries: diagnosis and treatment in the practice of a family doctor.

Prof. T.M. Tykhonova1, PhD O.Yu. Bychkova1, PhD T.S. Butova1, A.S. Vnukova2. 1 — V.N. Karazin Kharkiv National University 2 — Kharkiv Medical Academy of Postgraduate Education  The article presents data on prevalence, etiopathogenetic aspects, clinical manifestations, features of diagnosis and principles of treatment of myocardial muscle bridge. The attention of family doctors and pediatricians is…

Contribution of hypertension to the formation of endpoints of diseases of the circulatory system according to population studies

Prof. E.Ya. Nikolenko Kharkiv National University named after V.N. Karazin Circulatory system diseases occupy the first place in the mortality structure in Ukraine (63,7%), the endpoints generally accepted in clinical and epidemiological studies in most cases are formed due to CAD and its risk factors. The paper presents approaches to assessing the contribution of arterial…