PHD N.M. Kyrychenko
Sumy State University
Type 2 diabetes mellitus and related complications are serious global public health problem. The presence of chronic systemic inflammation associated with an increase body weight and changes in the functions and activity of adipose tissue can cause the development of disorders in the regulation of glucose metabolism and in the future lead to T2DM.
The purpose of the study was to determine the biomarkers of systemic inflammation in women with hypertension and obesity, depending on the presence or absence of type 2 diabetes.
Materials and methods. 70 patients aged 40 to 60 years were examined. Patients were divided into groups depending on the presence or absence of T2DM. Statistical data processing was performed using Statistica for Windows 6.0. Results. In women with III degree obesity, even in the absence of T2DM, higher levels of insulinemia, HOMA-IR and glycosylated hemoglobin were determined compared to patients with I and II degree of obesity. In patients with type 2 diabetes and grade III obesity, significantly higher levels of systemic inflammation biomarkers in the blood were recorded. Conclusions. Women with III degree obesity have significantly higher levels of glycemia and insulinemia compared with patients with I and II degree of obesity even in the absence of type 2 diabetes. The presence of type 2 diabetes in women is associated with significantly higher levels of systemic inflammation biomarkers in the blood.
Key Words: obesity, diabetes mellitus, inflammation, markers, arterial hypertension, women.