Levels of fibroblast growth factor and sulfated glycosoaminoglycans in connective tissue metabolism in patients with mitral valve prolapse and type 1 diabetes mellitus.

O.Ye. Nikolenko,  S.B. Pavlov*, O.M. Korzh*

V.N.Karazin Kharkiv National University, Ukraine.

*Kharkiv Medical Academy of Postgraduate Education, Ukraine

In order to study the influence of the main fibroblast growth factor on the indicators of the state of the main substance of the extracellular matrix, a comparative analysis of their levels in the blood serum was carried out in persons with mitral valve prolapse and type 1 diabetes mellitus. The data obtained showed that the highest level of FGF-2 was observed in patients with a combination of MVP and type 1 diabetes mellitus compared with isolated MVP and diabetes, the control group (p <0.01) Level II of the GAG ​​fraction, which is represented in the main substance of the extracellular the matrix of the heart valve apparatus was also the highest in comorbid pathology, significantly differing from the control group (p <0.05). The level of GAG fraction III was higher among diabetic patients, regardless of the presence or absence of MVP, which is associated with the localization of this GAG fraction in the basement membranes of blood vessels and may be one of the elements of the pathogenesis of diabetic angiopathy.

Key words: mitral valve prolapse, diabetes mellitus, main fibroblast growth factor, glycosaminoglycans

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