Pathogenetic features of the combined course of arterial hypertension and diabetes mellitus 2 type

Prof. Bilovol O.M., prof. Bobronnikova L.R., Al-Trawneh O.V. Kharkiv National Medical University.

In the article features of pathogenetic mechanisms of the combined course of arterial hypertension and type2 diabetes mellitus are considered. This pathology potentiates the development of micro- and macrovascularcomplications, raises cardiovascular risk. Concomitant abdominal obesity contributes to the imbalance ofadipocytokines, and complicates the course of type 2 diabetes. It was established that polymorphism of candidategenes associated with the development and progression of insulin resistance, which is of interest for further study.

Key Words: arterial hypertension, diabetes mellitus type 2, pathogenesis mechanisms of development, adipokines imbalance, gene polymorphism.

Belovol AN, Bobronnikova LR, Al’-Trawneh OV. [Pathogenetic features of the combined course of arterial hypertension and diabetes mellitus 2 type]. Shidnoevr. z. vnutr. simejnoi med. 2017;1:4-9. Russian.
https://dx.doi.org/10.15407/internalmed2017.01.004

Download.PDF

1. Sirenko YuN, translator.Klinichni rekomendatsii z arterialnoi hipertenzii Yevropeiskoho tovarystva hipertenzii (ESH) ta Yevropeiskoho tovarystva kardiolohiv (ESC) 2013 roku. HYPERTENSION. 2013;4:61—159.Ukrainian.
2. Medyko-demohrafichna sytuatsiia ta osnovni pokaznyky medychnoi dopomohy naselenniu v rehionalnomu aspekti: 2012 rik. Kyiv: The Ministry of Health of Ukraine, GA «Ukrainian Institute of Strategic Research of the Ministry of Health of Ukraine»; 2013. 190 p. Ukrainian.
3. Korolyuk OYa, Radchenko OM. [Prognostic value of criteria of metabolic syndrome in patients with ischemic heart disease and newly diagnosed hyperglycemia]. The Praktitioner. 2013;4:46—50. Ukrainian.
4. Tsukrovyi diabet, prediabet i sertsevo-sudynni zakhvoriuvannia: Metodychni rekomendatsii Robochoi hrupy Asotsiatsii kardiolohiv Ukrainy ta Asotsiatsii endokrynolohiv Ukrainy z metabolichnoho syndromu, diabetu, prediabetu i sertsevo-sudynnykh zakhvoriuvan. Kyiv: Asotsіatsіia kardіologіv Ukraini; 2014. 40 p. Ukrainian.
5. Arikoglu H, Ozdemir H, Kaya DE, Ipekci SH, Arslan A, Kayis SA, Gonen MS. The Adiponectin variants contribute to the genetic background of type 2 diabetes in Turkish population. Gene. 2014 Jan 15;534(1):10-6. PubMed PMID: 24404592.
6. De Cosmo S, Viazzi F, Piscitelli P, Giorda C, Ceriello A, Genovese S, Russo G, Guida P, Fioretto P, Pontremoli R; AMD-Annals Study Group. Blood pressure status and the incidence of diabetic kidney disease in patients with hypertension and type 2 diabetes. J Hypertens. 2016 Oct;34(10):2090-8. doi: 10.1097/HJH.0000000000001045. PubMed PMID: 27457667.
https://doi.org/10.1097/HJH.0000000000001045
7. Cai R, Yuan Y, Sun J, Xia W, Huang R. Statinsworsen glycemic control of T2DM in target LDL-c leveland LDL-c reduction dependent manners: a meta-analysis . Expert Opin,Pharmacother. 2016 Oct;17(14):1839-49. doi: 10.1080/14656566.2016.1220539.
https://doi.org/10.1080/14656566.2016.1220539
8. Cha SA, Yun JS, Lim TS,Hwang S, Yim EJ, Song KH, Yoo KD, Park YM, Ahn YB, Ko SH. Hypoglycemia and Cardiovascularor All-Cause Mortality in Patients with Type 2 Diabetes. Diabetes Metab J. 2016 Jun;40(3):202-10. doi: 10.4093/dmj.2016.40.3.202.
https://doi.org/10.4093/dmj.2016.40.3.202
9. Chung H-F, Long KZ, Hsu C-C. Adiponectin gene (AdipoQ)polymorphisms correlate with the progression of nephropathyin Taiwanese male patients with type 2 diabetes. Diabetes research and clinical practice. 2014;105(2):261—270. doi: 10.1016/j.diabres.2014.04.015.
https://doi.org/10.1016/j.diabres.2014.04.015
10. Charvát J. What is the significance of the phenomenonof hypertension in disguise in patients with type 2 diabetesmellitus treated for long-lasting hypertension?Vnitr Lek. 2016 Mar;62(3):215—217.
11. Gui M-H, Li X, Jiang S-F. Association of the adiponectin geners1501299 G>T variant, serum adiponectin levels, and the riskof coronary artery disease in a Chinese population.Diabetes research and clinical practice. 2012;97(3):499-504. doi: 10.7508/ibj.2016.03.004.
12. Gerstein HC, Pogue J. The relationship between dysglycaemiaand cardiovascular and renal risk in diabetic and non-diabeticparticipants in the HOPE study: a prospective epidemiologicalanalysis. Diabetologia. 2005;48(9):1749—1755.
https://doi.org/10.1007/s00125-005-1858-4
PMid:16059716
13. Hanis CL, Redline S, Cade BE. Beyond type 2 diabetes,obesity and hypertension: an axis including sleep apnea, leftventricular hypertrophy, endothelial dysfunction, and aorticstiffness among Mexican Americans in Starr County, Texas. Cardiovasc.Diabetol. 2016 Jun;8(15):86 p. doi: 10.1186/s12933-016-0405-6.
https://doi.org/10.1186/s12933-016-0405-6
14. Zhang H, Mo X, Hao Y Association between polymorphismsin the adiponectin gene and cardiovascular disease: a metaanalysis.BMC Medical Genetics. 2012;13:40. PMID:24516495
15. Wu J, Liu Z, Meng K, Zhang L Association of AdiponectinGene (ADIPOQ) rs2241766 Polymorphism with Obesity inAdults: A Meta-Analysis. 2014 April 16.doi: 10.1371/journal.pone.0095270.
https://doi.org/10.1371/journal.pone.0095270
16. Horr S, Nissen S. Managing hypertension in type 2 diabetesmellitus.Best Pract Res Clin Endocrinol Metab. 2016 Jun;30(3):445—54. doi: 10.1016/j.beem.2016.06.001.
https://doi.org/10.1016/j.beem.2016.06.001
17. Khalyfa A, Mutskov V, Carreras A, Khalyfa AA, HakimF, Gozal D. Sleep fragmentation during late gestationinduces metabolic perturbations and epigenetic changes inadiponectin gene expression in male adult offspring mice.Diabetes. 2014;63(3230):41. doi: 10.2337/db14-0202.
https://doi.org/10.2337/db14-0202
18. Leroith D. Pathophysiology of the metabolic syndrome:implications for the cardiometabolic risks associated with type2 diabetes. Am J Med Sci. 2012 Jan;3(1):13. doi: 10.1186/1741-7015-9-48.
https://doi.org/10.1186/1741-7015-9-48
19. Tureck LV, Leite N, Souza LR. AdipoQ single nucleotidepolymorphism: Association with adiponectin and lipoproteinslevels restricted to men. Meta Gene.2015:98—104.doi: 10.1016/j.mgene.2015.06.003.
https://doi.org/10.1016/j.mgene.2015.06.003
20. Husein AM. Association of the+45T>G adiponectin genepolymorphismwith insulin resistance in nondiabetic Saudiwomen. Gene. 2013;50:158—163. doi: 10.1016/j.gene.2013.07.003.
https://doi.org/10.1016/j.gene.2013.07.003
21. Mather KJ, Christophi CA, Jablonski KA.Common variantsin genes encoding adiponectin (ADIPOQ) and its receptors(ADIPOR1/2), adiponectin concentrations, and diabetesincidence in the Diabetes Prevention Program.
Diabetic medicine. 2012;29(12):1579 — 1588. doi: 10.1111/j.1464-5491.2012.03662.x.
https://doi.org/10.1111/j.1464-5491.2012.03662.x
22. Yao M, Wu Y, Fang Q. Association of ADIPOQ variants withtype 2 diabetes mellitus susceptibility in ethnic Han Chinesefrom northeast China. J Diabetes Investig. 2016;7(6):205—210. doi: 10.1111/jdi.12535.
https://doi.org/10.1111/jdi.12535
23. Mohammedi K, Woodward M, Hirakawa Y. Microvascularand Macrovascular Disease and Risk for Major PeripheralArterial Disease in Patients With Type 2 Diabetes. Diabetes Care. 2016 Jul:26—30. doi: 10.2337/dc16-0588.
https://doi.org/10.2337/dc16-0588
24. Nasser MR. Association of Adiponectin Gene Polymorphism(þT45G) With Acute Coronary Syndrome and CirculatingAdiponectin Levels. Angiology. 2012;64(4):257—265. doi: 10.1016/j.gene.2011.11.045.
https://doi.org/10.1016/j.gene.2011.11.045
25. Nibouche WN, Biad A. Arterial hypertension at the time ofdiagnosis of type 2 diabetes in adults. Ann Cardiol Angeiol, Paris. 2016 Jun;65(3):152—8. doi: 10.1016/j.gene.2011.11.045.
https://doi.org/10.1016/j.gene.2011.11.045
26. Oliveira CSV, Saddi-Rosa P, Crispim F. Associationof ADIPOQ variants, total and high molecular weightadiponectin levels with coronary artery disease in diabeticand non-diabetic. Brazilian subjects. Journal of diabetes and its complications.2012;26(2):94—98. doi: 10.1111/jdi.12133.
https://doi.org/10.1111/jdi.12133
27. Okada-Iwabu M, Yamuchi T, Iwabu M. A small-moleculeAdipoR agonist for type 2 diabetes and short life in obesity.Nature. 2013;50:493—9. doi: 10.1038/nature12656.
https://doi.org/10.1038/nature12656
28. Razavian N, Blecker S, Schmidt AM. Prediction of Type 2Diabetes From Claims Data and Analysis of Risk Factors. Big Data. 2015 Dec; 3(4):277—87. doi: 10.1053/j.ajkd.2012.04.025.
https://doi.org/10.1053/j.ajkd.2012.04.025
29. Ren J, Anversa P. The insulin-like growth factor I system:physiological and pathophysiological implication incardiovascular diseases associated with metabolic syndrome.Biochem Pharmacol. 2015 Feb;93(4):409—17. doi: 10.1016/j.bcp.2014.12.006.
https://doi.org/10.1016/j.bcp.2014.12.006
30. Savanelli MC, Scarano E, Muscogiuri G. Cardiovascularrisk in adult hypopituitaric patients with growth hormonedeficiency: is there a role for vitamin D? Endocrine. 2016 Apr;52(1):111—9. doi: 10.4103/2230-8210.84865.
https://doi.org/10.4103/2230-8210.84865
31. Kalyani RR, Golden S. Diabetes and Prediabetes and Riskof Hospitalization: The Atherosclerosis Risk in Communities(ARIC) Study. Diabetes Care. 2016 May;39(5):772—9. doi: 10.2337/dc15-1335.
https://doi.org/10.2337/dc15-1335
32. Skau JK, Nordin AB, Cheah JC. A complex behavioural changeintervention to reduce the risk o2 diabetes and prediabetes inthe pre-conception period in Malaysia: study protocol for arandomised controlled trial. Trials. 2016 Apr;17(1);215. doi: 10.1007/s00394-009-0008-z.
https://doi.org/10.1007/s00394-009-0008-z
33. Stöckl D, Rückert-Eheberg IM, Heier M. Regional Variability of Lifestyle Factors and Hypertension with Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus: The Population-Based KORA-F4 and SHIP-TREND Studies in Germany. PLoSOne. 2016 Jun:11. doi: 10.1371/journal.pone.0156736.
https://doi.org/10.1371/journal.pone.0156736
34. Sang HC, Ji WB, Eun SK. Gender Diferences inHypertension Control Among Older Korean Adults: KoreanSocial Life, Health, and Aging Project. J Prev Med Public Health. 2015;48:20. doi: 10.3961/jpmph.14.043.
https://doi.org/10.3961/jpmph.14.043
35. Takhshid MA, Haem Z, Aboualizadeh F. The associationof circulating adiponectin and 45T/G polymorphism ofadiponectin gene with gestational diabetes mellitus in Iranianpopulation.J Diabet Metab Disord. 2015;14:30. doi: 10.1186/s40200-015-0156-z.
https://doi.org/10.1186/s40200-015-0156-z
36. Ramya K, Ayyappa KA, Ghosh S. Genetic association ofADIPOQ gene variants with type 2 diabetes, obesity andserum adiponectin levels in south Indian population. Gene. 2013;532:253—262. doi: 10.1016/j.gene.2013.09.012.
https://doi.org/10.1016/j.gene.2013.09.012
37. Tu Y, Yu QL, Fan GR. Assessment of type 2 diabetes riskconferred by SNPs rs2241766 and rs1501299 in the ADIPOQgene, a case control study combined with metaanalyses. Mol Cell Endocrinol.2014;396:1-9. doi: 10.1111/jdi.12535.
https://doi.org/10.1111/jdi.12535
38. Peters KE, Beilby J, Cadby GA. Comprehensive investigationof variants in genes encoding adiponectin (ADIPOQ) andits receptors (ADIPOR1/R2), and their association withserum adiponectin, type 2 diabetes, insulin resistance and themetabolic syndrome.BMC Medical Genetics. 2013;14:14—15. doi: 10.1186/1471-2350-14-15.
https://doi.org/10.1186/1471-2350-14-15
39. Fan Y, Wang K, Xu S. Association between ADIPOQ +45T>Gpolymorphism and type 2 diabetes: a systematic review andmeta-analysis.Int J Mol Sci. 2014;16:704—723. doi:10.3390/ijms16010704.
https://doi.org/10.3390/ijms16010704
40. Use of Glycated Haemoglobin (HbA1c) in the Diagnosisof Diabetes Mellitus. Abbreviated Report of a WHOConsultation. Geneva. 2011:25. PMID: 26158184.
41. Wijkman M, Länne T, Östgren CJ. Diastolic orthostatichypertension and cardiovascular prognosis in type 2 diabetes:a prospective cohort study. Cardiovasc Diabetol. 2016 Jun;15:83. doi: 10.1186/s12933-016-0399-0.
https://doi.org/10.1186/s12933-016-0399-0
42. Yaghootkar H, Lotta LA. Tyrrell J. Genetic Evidence for aLink Between Favorable Adiposity and Lower Risk of Type2 Diabetes, Hypertension, and Heart Disease.Diabetes. 2016 Aug;65(8):2448—60. doi: 10.2337/db15-1671.
https://doi.org/10.2337/db15-1671