Acute kidney injury: modern view of problem

Prof. Z.D. Semidotska, PHD. I.A. Chernyakova, PHD O.M. Pionova, PHD N.S. Tryfonova. Kharkiv National Medical University. Department of Propedeutics of Internal Medicine № 2 and nursing

The modern view of acute kidney injury as a global issue is presented in this article. The application of the concept of acute kidney injury in practical public health care is viewed as a strategic approach to reducing overall mortality and increase life expectancy.

Key Words: acute kidney failure, acute kidney injury, biomarkers of renal tissue damage, chronic renal disease.

Semidotska ZD, Chernyakova IA, Pionova OM, Tryfonova NS. [Acute kidney injury: modern view of problem]. Shidnoevr. z. vnutr. simejnoi med. 2017;1:10-16.Russian


1. Alvelos M, Pimentel R, Pinho E, Gomes A, LourencoP Teles MJ, Almeida P, Guimarães JT, Bettencourt P. Neutrophil Gelatinase — Associated Lipocalin in the Diagnosis of type 1 Cardio —Renal Syndromein the General Ward. Clin J Am Soc Nephrol. 2014;6:476 — 481. doi: 10.1515/cclm-2012-0307.
2. Bellomo R, Ronco C, Kellum JA,Mehta RL,Palevsky P, and the ADQI workgroup. Acute renal failure — definition, outcome,measures, animae models, fluid therapy and informationtechnology needs. The second International Consensus Conference of theAcute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2008;8:204 — 212. doi :10.1186/cc2872.
3. Bouman C, Kellum JA, Levin N. Definition of acute renal failure. Acute Dialisis Quality Initiative.2nd International Consensus Conference, National Kidney Foundation KD: Clinical practice guidelines for chronicKidney Disease: Evaluation, classification and stratification. 2002;39(Suppl.1): 1—266. doi: 10.1681/ASN.2008070669.
4. Case J, Khan S, Khan A, Khalid R. Epidemiology of acute kidney injury in the intensivecare unit. Crit Care Res Pract. 2013; 2013: 479730. doi: 10.1155/2013/479730.
5. Chen C, Yang X, Lei Y, Zha, Liu H,Zha Y, Liu H, Ma C, Tian J, Chen P, Yang T, Hou FF. Urinary biomarkers at the time of AKI diagnosis as predictors of progression of AKI among patients with acutecardiorenal syndrome. Clin J Am Soc Nephrol. 2016;11:1536—1544. doi: 10.1681/ASN.2014040408.
6. Chertow JM, Burdick E, Honour M,Bonventre JV, Bates DW.Acute kidney injury, mortality, length of stay and costs in hospitalized patients. A randomized clinical study. J Am Soc Nephrol. 2005;16:3365-3370. doi: 10.1681/ASN.2004090740.
7. Danesi R, Fontanella B, Lombardi C, Milani P, Verzura G, Cotter G, Dittrich H, Massie BM, Dei Cas L. Worsening renal function in patients hospitalized for acute heart failure: Clinical implications and prognosticsignificance. European Journale Heart Failure. 2008;10:188—195. doi: 10.1016/j.ejheart.2008.01.011.
8. Darmon M, Vincent F, Canet E,Mokart D, Pène F, Kouatchet A, Mayaux J, Nyunga M, Bruneel F, Rabbat A, Lebert C, Perez P, Renault A, Meert AP, Benoit D, Hamidfar R, Jourdain M, Schlemmer B, Chevret S, Lemiale V, Azoulay E.Acute kidney injury in critically ill patients with haematological malignancies: results of a multicentrecohort study from the Groupe de Rechercheen Reanimation Respiratoireen Onco-Hematologie. Nephrol Dial Transplant. 2015;30 (12): 2006—2013. doi: 10.1093/ndt/gfv372.
9. Edelstein CL, editor. Biomarkers of Kidney Disease.1st Edition. London: Elsevier inc.; 2011. 454 p.
10. Geus H, Betjes M, Bakker J. Biomarkers for the prediction of acute kidney injury:a narrative review on current status and future challenges. Clin Kidney. 2012:5(2):102—108. doi: 10.1093/ckj/sfs008.
11. Han WK, Wagener G, Zhu J,Wang S, Lee HT. Urinary biomarkers in the early detection of acutekidney injury after cardiac surgery. Clin J Am Soc Nephrol. 2009;4:873—882. doi: 10.2215/CJN.04810908.
12. Heller F, Frischmann S, Gru”nbaum M, Zidek W, Westhoff TH. Urinary Calprotectin and the Distinction between Prerenal and Intrinsic Acute Kidney Injury. Clin J Am Soc Nephrol. 2011;6:2347-2355. doi: 10.2215/CJN.02490311.
13. Hoste EA, Clermont J, Kersten A, Venkataraman R, Angus DC, De Bacquer D, Kellum JA. RIFLE criteria for acute kidney injury are associatedwith hospital mortality in critically ill patients a cohort analysis. Crit Care. 2006; 10(3):73. doi: 10.1186/cc4915.
14. Joanidis M, Metnitz PQ. Epidemiology and natural history of acute renalfailure in the ICU. Crit Clin. 2005;21:239 — 249. doi: 10.1155/2013/721810.
15. John PR, Anderson BJ, Mangalmurti NS, Nguyen TD,Holena DN, Wu Q, Nguyen ET, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MG. The ABO Histo-Blood Group and AKI in critically ill patients with trauma or sepsis. Clin J Am Soc Nephrol. 2015;10: 1911—1920. doi: 10.2215/CJN.12201214.
16. Kashani K, Al —Khafaji A, Ardiles T,Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS, Davison DL, Feldkamp T, Forni LG, Gong MN, Gunnerson KJ, Haase M, Hackett J, Honore PM, Hoste EA, Joannes-Boyau O, Joannidis M, Kim P, Koyner JL, Laskowitz DT, Lissauer ME, Marx G, McCullough PA, Mullaney S, Ostermann M, Rimmelé T, Shapiro NI, Shaw AD, Shi J, Sprague AM, Vincent JL, Vinsonneau C, Wagner L, Walker MG, Wilkerson RG, Zacharowski K, Kellum JA.Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care. 2013;17:25. doi: 10.1186/cc12503.
17. KDIGO Clinical Practice Guideline for Acute KidneyInjury. Kidney int Suppl. 2012; 2(1). doi:10.1038/kisup.2011.35.
18. Kimmel M, Shi J, Latus J, Wasser C, Kitterer D, Braun N, Alscher MD. Association of Renal Stress/Damage and Filtration Biomarkers with Subsequent AKI during Hospitalization among Patients Presenting to the Emergency Department. Clin J Am Soc Nephrol. 2016 Jun 6;11(6):938-46. doi: 10.2215/CJN.10551015. Epub 2016 Mar 29. PubMed PMID: 27026519; PubMed Central PMCID: PMC4891754.
19. Khatri M, Himmelfart J, Adams D,Becker K, Longstreth WT, Tirschwell DL.Acute kidney injury is associated with increased hospital mortality after stroke. Stroke Cerebrovask. 2014;23(1):25—34. doi: 10.1161/STROKEAHA.115.010985.
20. Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, De Zeeuw D, Hostetter TH, Lameire N, Eknoyan G.Definition and classification of chronic kidney disease: a position statement from kidney disease: Improvingglobal outcomes (KDIGO). Kidney J. 2005;67 (6):2089 — 2100. doi:10.1111/j.1523-1755.2005.00365.x.
21. Loh V, VcArthur DL, Vespa P. The risk of acute radiocontrast — mediated kidney injury following endovascular therapy for acute ischemicstroke is low. AGNR Am J Neuroradiol. 2010;31(9):1584—1587. doi: 10.4103/1995-705X.125926.
22. Martensson J, Marting CR, Bell M. Novel biomarkers of acute kidney injury andfailure: clinical applicability. Anaesth BrJ. 2012;109(6):843—850. doi: 10.1093/bja/aes357.
23. Melnikov VJ, Molitoris BA. Improvements in the diagnosis of acute kidneyInjury.Saudi J Kidney Disease Transplantology. 2008;19 (4):537—544. PMID: 18580009.
24. Murugan R. Outcome in acute kidney injury. Crit Care. 2007;11(2):31. doi: 10.1186/s13054-016-1478-z.
25. Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D’Agati V, Devarajan P, Barasch J. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injur. Clin Invest. 2005;3:610—621. doi: 10.1172/JCI200523056.
26. Murray PT, Mehta RL, Shaw A,Ronco C, Endre Z, Kellum JA, Chawla LS, Cruz D, Ince C, Okusa MD, ADQI 10 workgroup.Potential use of biomarkers in acute kidney injury:report and summary of recommendations from the 10th Acute
Dialysis Quality Initiative consensus conference.Kidney Int. 2014; 85:513—521.doi: 10.1038/ki.2013.374.
27. Murray PT, Devarajan P, Levey AS,Eckardt KU, Bonventre JV, Lombardi R, Herget-Rosenthal S, Levin A. A framework and key research questions in AKI diagnosis and staging in different enviroments. Clin J Am Soc Nephrol. 2008;3:864 — 868. doi: 10.2215/CJN.04851107.
28. National Kidney Foundation KD: Clinical practice quidelinesfor chronic kidney disease: Evaluation, classification andstratification. Am J Kidney Disease. 2002;39 Suppl 1:1—266. PMID:11904577.
29. Nickolas TL, Schmidt-Ott KM, Canetta P, Forster C, Singer E, Sise M, Elger A, Maarouf O, Sola-Del Valle DA, O’Rourke M, Sherman E, Lee P, Geara A. Imus P, Guddati A, Polland A, Rahman W, Elitok S, Malik N,Giglio J, El-Sayegh S, Devarajan P, Hebbar S, Saggi SJ, Hahn B, Kettritz R, Luft FC, Barasch J. Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephrondamage. Amulticenter prospective cohort study. J Am Coll Cardiol. 2012;59:246—255. doi: 10.1016/j.jacc.2011.10.854.
30. Noto A, Cibecchini F, Fanos V,Mussap M. NGAL at metabolomics: the single biomarker to reveal the metabolome alterations in kidney injury. Biomed Res Int. 2014:602526. doi: 10.1155/2013/612032.
31. Ostermann M, Chang RW. Acute kidney injury in the intensive care unitaccording to RIFLE. Crit CareMed. 2007;35:1837—1843. doi: 10.1038/srep23022.
32. Piccinni P, Crutz DN, Gramaticopolo S, Garzotto F, Dal Santo M, Aneloni G Dal Santo M, Aneloni G, Rocco M, Alessandri E, Giunta F, Michetti V, Iannuzzi M, Belluomo Anello C, Brienza N, Carlini M, Pelaia P, Gabbanelli V, Ronco C, NEFROINT Investigators. Prospective multicenter study an epidemiology of acute kidney injury in the ICU in critical care nephrology Italian collaborative effort. Minerva Anestesiol. 2011; 77:1072—1083. PMID:21597441.
33. Lombardi R, Nin N, Lorente JA,Frutos-Vivar F, Ferguson ND, Hurtado J, Apezteguia C, Desmery P, Raymondos K, Tomicic V, Cakar N, González M, Elizalde J, Nightingale P, Abroug F, Jibaja M, Arabi Y, Moreno R, Matamis D, Anzueto A, Esteban A, for the VENTILA Group. An assessment of the acute kidney injury network creatinne-based criteria in patients submitted to mechanical ventilation. Clin J Am Soc Nephrol. 2011;6:1547—1555. doi: 10.2215/CJN.09531010.
34. Ricci Z, Ronco C. New insights in acute kidney failure in the critically ill.Swiss Med Wkly. 2012;142:13662. doi: 10.5935/0103-507X.20130024.
35. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A,Cohen DJ, Devarajan P, Barasch J.Dual Action of Neutrophil Gelatinase Associated Lipocalin. Journal American Society Nephrology. 2007;18:407—413. doi: 10.1039/C5RA18736B.
36. Singbart LK, Kellum JA. AKI in the ICU: definition, epidemiology, riskstratification and outcomes. Kidney Int. 2012;81:819—825. doi: 10.1038/ki.2011.339.
37. Slocum JL, Heung M, Pennathur S. Marking renal injury: can we move beyond serum creatinine? Transpl Res. 2012;159 (4):277—289. doi: 10.1016/j.trsl.2012.01.014.
38. Thakar CV, Christianson A, Himmelfarb J, Leonard AC. Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. Clin J Am Soc Nephrol. 2011;6:2567—2572. doi: 10.2215/CJN.01120211.
39. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C, for the Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators. Acute renal failure in critically ill patients — a multinational, multicenter study.JAMA.2005; 294:813—818.doi: 10.1001/jama.294.7.813.
40. Waikar SS, Lin KD, Chertow JM. Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol. 2008;3(3):844—861. doi: 10.2215/CJN.05191107.
41. Warnosk DG, Levin A. Acute kidney injury Network (AKIN): Reportof an initiative to improve outcomes. Crit Care. 2007;11:31. doi:10.1186/cc5713.
42. Xue JL, Daniels F, Star RA, Kimmel PL, Eggers PW, Molitoris BA, Himmelfarb J, Collins AJ. Incidence and mortality of acute renal failure in medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol. 2006;17:1135—1142. doi: 10.2215/CJN.04961107.
43. Kaiukov IG, Smirnov AV, Emanuel’ VL. Tsistatin S v sovremennoi meditsine.Nefrologiia. 2012;16(1):22—39. Russian.
44. Menzorov MV, Shutov AM, Luk’ianova V, Gerdt AM., Grishen’kin IIu. Ostroe povrezhdenie pochek u bol’nykh s insul’tom.Nefrologiia.2014; 2:55—60.Russian.
45. Piradov MA, Gulevskaia TS, Gnedovskaia EV i dr. Sindrom poliorgannoi nedostatochnosti pritiazhelykh formakh insul’ta (kliniko-morfologicheskoe issledovanie). Nevrologicheskii zhurnal. 2006;11(5):9—13. Russian.
46. Serov VA, Shutov AM, Kuzovenkova MIu, Krainova NV, Garagedian IuT, Staraia MM, Ivanova IaV. Ostroe povrezhdenie pochek u bol’nykh vnebol’nichnoi pnevmoniei.Klinicheskaia nefrologiia. 2015;2—3:17—20. Russian.
47. Smirnov AV, Dobronravov VA, Rumiantsev Ash, Kaiukov IG. Ostroe povrezhdenie pochek.MIA; 2015.488 p. Russian.
48. Smirnov AV, Kaiukov IG, Dobronravov VA, Rumiantsev ASh. Ostroe povrezhdenie pochek.Nefrologiia. 2014;2:8—25. Russian.
49. Smirnov AV, Dobronravov VA, Rumiantsev ASh, Shilov EM, Vatazin AV, Kaiukov IG, Kucher AG, Esaian AM. Natsional’nye rekomendatsii. Ostroe povrezhdenie pochek: osnovnye printsipy diagnostiki, profilaktiki i terapii. Nefrologiia. 2016;20(1): 79—04. Russian.