Atrial fibrillation in diabetic patients.

Prof. S.A. Serik, PHD V.I. Strona National Institute of Therapy. L.T. Malaya NAMS of Ukraine, Kharkiv The article summarizes the main clinical and theoretical data on features of atrial fibrillation (AF) course in combination with diabetes mellitus (DM). The potential relationship between these comorbid conditions is analyzed on the basis of the results of epidemiological…

The role of adipose tissue hormones in the formation and course of gastroesophageal reflux disease in combination with obesity.

Prof. O.A. Oparin, O.M. Malіar, PHD T.N. Oparina, E. J. Abakumova Kharkiv Medical Academy of Postgraduate Education Objective: To investigate the level of leptin in patients with gastroesophageal reflux disease with concomitant obesity and evaluate its effect on the course of the disease. Materials and results. The study involved 50 patients. The first group included…

The relationship between diabetes mellitus and heart rhythm disorders: a focus on common pathophysiological mechanisms and modern treatment strategies.

Prof. Zhuravlyova L.V., PHD Sokolnikova N.V., PHD Rogachova T.A.  Kharkiv National Medical University The aim of this review article is the analysis the latest evidence based scientific data on the pathophysiological association between diabetes mellitus and heart arrhythmias and the most acceptable treatment possibilities for their correction. In recent decades, the worldwide prevalence of diabetes…

Optimization of the diagnosis of preclinical renal dysfunction in arterial hypertension and its combination with type 2 diabetes mellitus.

Hajibabirova Lala Mehman Scientific Research Institute of Cardiology named after J. Abdullayev, Baku. In order to optimize the diagnosis of early renal dysfunction in patients with arterial hypertension and its combination with type 2 diabetes mellitus, we examined 100 patients aged 35 to 58 years (mean age 46.8 ± 0.68). The first group included 50…

The importance of vaspin in external and internal secretory activity of the pancreas.

 D. Pylov Kharkiv National Medical University, Department of Internal Medicine №3 and Endocrinology To analyze the data of the scientific literature on the importance of vaspin as a pathogenetic link in the development of insufficiency of exocrine function of the pancreas in type 2 diabetes patients in combination with chronic pancreatitis and. Literary sources were searched…

Levels of fibroblast growth factor and sulfated glycosoaminoglycans in connective tissue metabolism in patients with mitral valve prolapse and type 1 diabetes mellitus.

O.Ye. Nikolenko,  S.B. Pavlov*, O.M. Korzh* V.N.Karazin Kharkiv National University, Ukraine. *Kharkiv Medical Academy of Postgraduate Education, Ukraine In order to study the influence of the main fibroblast growth factor on the indicators of the state of the main substance of the extracellular matrix, a comparative analysis of their levels in the blood serum was…

Molecular mechanisms of insulin resistance in normal pregnancy and gestational diabetes

Prof. L.V. Zhuravlyova, PhD N.V. Sokolnikova, PhD T.A. Rogachova Kharkiv National Medical University The purpose of this review article is to analyze current information on the molecular mechanisms of gestational diabetes and the prospects for their use in the further development of new effective treatments for this common pathology. Decreased ability of insulin to bind…

Clinical and pathogenetic rationale for the prevention and treatment of obesity.

Prof. O.M. Korzh. Kharkiv Medical Academy of Postgraduate Education. Numerous studies in recent years have identified obesity as a key cause of the development of type 2 diabetes, metabolic syndrome and cardiovascular diseases, which are among the most significant public health problems in most countries of the world. The high prevalence of obesity, which determines…

The role of dipeptidylpeptidase-4 inhibitors in the current therapy of type 2 diabetes mellitus.

Prof. L.V. Zhuravlyova, M.V. Filonenko. Kharkiv National Medical University. Recent advances in the study of the pathogenesis of type 2 diabetes, including the mechanisms of regulation of postprandial blood glucose level, have led to the emergence of new treatment strategies aimed at overcoming dysfunction of the Langerhans islands, including those that affect the incretine hormones…

Clinical-pathogenetic parallels in the combined course of autoimmune tyreoiditis and gastroesophageal reflux disease among young adults

N.A. Yarantseva Kharkіv Medical Academy of Postgraduate Education, Department of Therapy, Rheumatology and Clinical Pharmacology  The purpose of this article is to study the general pathogenetic mechanisms and features of the clinical picture in the combined course of GERD and AIT. The autoimmune process leads to inflammation in the tissues of the thyroid gland its…

Autoimmune thyroiditis: a look at the problem through the eyes of a family doctor

E.Ya Nikolenko., O.A. Salun, K.V.Vovk, E.L.Pavlova N. Karazin Kharkiv National University, Department of General Practice-Family Medicine This article is about autoimmune thyroid disease, the causes of this pathology, factors of development of AIT. Recent studies have shown that gene mutations, including regulatory genes, cause the development of thyroid, including AIT, so far there is no…

Biomarker of systemic inflammation in women with arterial hypertension and obesity, depending on the presence of type 2 diabetes.

PHD N.M. Kyrychenko Sumy State University Type 2 diabetes mellitus and related complications are serious global public health problem. The presence of chronic systemic inflammation associated with an increase body weight and changes in the functions and activity of adipose tissue can cause the development of disorders in the regulation of glucose metabolism and in…

Heart failure in patients with diabetic cardiomyopathy: modern methods of treatment

Prof. L.V. Zhuravlyova, N.V. Sokolnikova, T.A. Rogachova Kharkiv National Medical University  Currently, all over the world, type 2 diabetes mellitus and the heart failure are developing into an epidemic. For the first time, diabetic cardiomyopathy as an independent diagnostic unit was described in 1972 by Shirley Rubler and colleagues. Currently, the most common phenotype of…

Heart failure in patients with diabetic cardiomyopathy: features of pathogenesis and diagnosis

Prof. L.V. Zhuravlyova, as. prof. T.A. Rogachova, as. prof. N.V. Sokolnikova. Kharkiv National Medical University Currently, all over the world, type 2 diabetes mellitus and the heart failure are developing into an epidemic. In 1972, Shirley Rubler and colleagues defined cardiomyopathy, which was independent of atherosclerosis and hypertension, as diabetic cardiomyopathy. Recently, the so-called restrictive type…

Cardiovascular complications in diabetes mellitus: the role of hyperglycemia

Prof. O.M. Korzh. Kharkiv Medical Academy of Postgraduate Education. The article discusses the relationship of glycemia control with the development of mid-vascular pathology. Proved a clear link glycemic control with a reduced risk of micro- and macrovascular complications of diabetes. At present, the ideology of early intervention is actively developing and is gaining more and…

Menopausal hormone therapy: modern state of the problem

Prof. L.V. Zhuravlyova, T.A. Rogachova. Kharkiv National Medical University. The article contains a review of current international guidelines for conducting menopausal hormone therapy (MHT). The problem of inefficiency and risks of MHT associated with impaired metabolism of sex hormones in the elderly and in a number of common pathological conditions, especially in the metabolic syndrome,…

Patient with hyperchlicemia at the family doctor

PhD Pasiieshvili T.M., Koryak V.V.* Kharkiv National Medical University.Department of General Practice — Family Medicine and Internal Diseases. *Educational and scientific medical complex «University Clinic» of KhNMU Issues of prevalence, preconditions for the course of diabetes mellitus are considered in the paper. The role of insulin in the body is determined. Nosologies in which hyperglycemia…

Features of insulin therapy in patients with type 1 diabetes mellitus during pregnancy

Prof. Zhuravlyova LV, Rogachova TA Kharkiv National Medical University. Until recently, pregnancy in type 1 diabetes mellitus caused high risk of complications for the mother and severe congenital abnormalities for the child. The main problems of pregnant women with diabetes were difficulties in achieving stable normal blood glucose level, avoiding hypoglycemia and ketoacidosis. Control of DM-1…

Prospects for the rehabilitation of patients with type 2 diabetes mellitus

Prof. O. N. Beletskaya Kharkiv medical academy of postgraduate education The perspectives of treatment of patients with type 2 diabetes mellitus in the paradigm of physical and rehabilitation medicine are considered. The concept of pathogenesis of type 2 diabetes is proposed, as a consequence of the age and constitutional predisposition to disadaptation of the organism…