Modern aspects of pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension in the presence or absence of сhronic kidney disease

Prof. K. Prosolenko, ass. К. Lapshyna, V. Ryabuha   Kharkiv National Medical University.  Government Institution “L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine”  The article presents the main aspects of the pathogenesis of comorbidity of non-alcoholic fatty liver disease and hypertension. These diseases are very often presented as comorbidities in…

Modern understanding of mucoviscidosis.

Prof. T.D. Zvyagintseva, as. Ya. K. Gamanenko. Kharkiv medical academy of postgraduation education   Detailed description of difficulties which may appear in diagnostic of mucoviscidosis and the ways of their overcoming are reported. The diagnostic algorithms are presented. Principles of basic therapy and particularities of treatment of mucoviscidosis in different age groups are considered.  Key words:…

Features of the quality of life in patients with a non-erosive form of gastroesophageal reflux disease with concomitant chronic obstructive pulmonary disease in young people.

Prof. A.G. Oparin, N.V. Semenova, PHD T.N. Oparina Kharkiv Medical Academy of Postgraduate Education Chronic obstructive pulmonary disease (COPD) is most commonly associated with gastroesophageal reflux disease (GERD). There are practically no studies of the quality of life in young patients. The aim of our study is to study the characteristics of the quality of…

The role of adipose tissue hormones in the formation and course of gastroesophageal reflux disease in combination with obesity.

Prof. O.A. Oparin, O.M. Malіar, PHD T.N. Oparina, E. J. Abakumova Kharkiv Medical Academy of Postgraduate Education Objective: To investigate the level of leptin in patients with gastroesophageal reflux disease with concomitant obesity and evaluate its effect on the course of the disease. Materials and results. The study involved 50 patients. The first group included…

Combined detection of inorganic syndromes of the gastrointestinal tract and their differential diagnosis.

R. I. Khalafova Polyclinic of the Higher Military School named after H.A. Aliyev To study the frequency of detection of combinations of the main syndromes of the gastrointestinal tract (GIT) and their differential diagnosis, consisting of irritable bowel syndrome (IBS), syndrome of functional dyspepsia (SFD), chronic idiopathic dyspepsia (CIT) and gastroesophageal reflux disease (GERD).   The…

Features of the clinical course and motorsecretory disorders in gastroesophageal reflux disease in overweight patients.

Prof. Oparin O.A., Maliar O.M., Fedchenko Yu.G. Kharkiv Medical Academy of Postgraduate Education Objective: To study the mechanisms of motor-secretory disorders in young patients with gastroesophageal reflux disease with concomitant obesity. Materials and results. The study involved 55 patients. The first group included patients with GERD with concomitant obesity, the second group included patients with…

Issues of inflammatory bowel disease management in primary care

PHD M. Brynza, аs. K. Uvarova V. N. Karazin Kharkiv National University Іnflammatory bowel diseases are among various chronic processes, which, in the case of inadequate diagnosis and irrational treatment, eventually lead to highly unfavorable consequences. Thus, the timely establishment of the diagnosis, as well as the prescription of effective therapy and the subsequent careful…

Biological diagnosis of inflammatory bowel disease: current ideas and future achievements.

Prof. T.D. Zvyagintseva, A.V. Yaroshenko Kharkiv medical academy of postgraduation education  Article presents review of new biological methods for the diagnosis of IBD. The problem of late diagnosis of IBD remains relevant because of increased frequency of adverse consequences of the disease by increasing the length of the period when patients do not receive adequate…

The importance of vaspin in external and internal secretory activity of the pancreas.

 D. Pylov Kharkiv National Medical University, Department of Internal Medicine №3 and Endocrinology To analyze the data of the scientific literature on the importance of vaspin as a pathogenetic link in the development of insufficiency of exocrine function of the pancreas in type 2 diabetes patients in combination with chronic pancreatitis and. Literary sources were searched…

Helicobacter pylori in the clinic of internal medicine

Prof. T.D. Zvyagintseva, as. Ya. K. Gamanenko Kharkiv medical academy of postgraduation education The article is devoted to the analysis of the literature on the problem of the possible relationship of Helicobacter pylori in the pathogenesis of various extragastric pathologies – diabetes mellitus, metabolic syndrome, cardiovascular diseases and multiple sclerosis. It is possible that Helicobacter…

Biliary pancreatitis: reasons of development and going near treatment

Prof. T.D. Zvyagintseva, as. Ya. K. Gamanenko. Kharkiv Medical Academy of Postgraduate Education Biliary pathology is the most common cause of the development of acute and exacerbation of chronic pancreatitis. A feature of biliary pancreatitis, which distinguishes it from other forms of pancreatitis, is the combination of exocrine pancreatic insufficiency with chronic biliary insufficiency, which…

The role of melatonin in the complex treatment of patients with gastroesophageal reflux disease with sleep apnea syndrome

Prof. A.G. Oparin, M.A. Murghuzov Kharkiv Medical Academy of Postgraduate Education The study showed that the inclusion of melatonin in the standard treatment regimen for patients with GERD with concomitant obstructive sleep apnea syndrome is not only clinically justified, it also shortens the onset of clinical remission of both the main and concomitant pathologies, with…

Clinical-pathogenetic parallels in the combined course of autoimmune tyreoiditis and gastroesophageal reflux disease among young adults

N.A. Yarantseva Kharkіv Medical Academy of Postgraduate Education, Department of Therapy, Rheumatology and Clinical Pharmacology  The purpose of this article is to study the general pathogenetic mechanisms and features of the clinical picture in the combined course of GERD and AIT. The autoimmune process leads to inflammation in the tissues of the thyroid gland its…

Sleep disorders, its mechanisms, and correction in patients with gastroesophageal reflux disease and neurocirculatory dystonia

I.O. Balaklytska Kharkiv Medical Akademy of Postgraduate Education This article addresses the issue of the part of melatonin—serotonin system in the mechanisms of formation of insomnia with GERD accompanied by NCD. We conducted a study of four groups of patients suffering from GERD with insomnia and from GERD accompanied by NCD with insomnia. Two groups…

The effect of adiponectin gene polymorphism on the severity of metabolic disorders and some liver parameters in patients with non-alcoholic fatty liver disease in combination with hypertension

K.О. Prosolenko Kharkiv National Medical University. The aim of the work was to study the relationship of the genetic polymorphism of the G276T marker of the ADIPOQ gene with the severity of metabolic disorders and changes in some liver indices with comorbidity of hypertension (Н) and non-alcoholic fatty liver disease (NAFLD). The object of the…

The role of endothelin-1 and melatonin in the mechanisms of the comorbid course of gastroesophageal reflux disease and obstructive sleep apnea syndrome

Prof. A.G. Oparin, M.A. Murghuzov Kharkiv Medical Academy of Postgraduate Education As revealed in studies in young patients with GERD, there is a statistically significant decrease in the level of melatonin metabolite (6-COM) and a statistically significant increase in the content of endothelin-1 compared with a group of healthy individuals of the same age and…

Family doctor’s tactics for biliary tract diseases (diagnostic criteria)

Ass.prof. K.V. Vovk, ass.prof. O.V. Sokruto, ass.prof. O.G. Reznichenko, ass.prof. S.V. Gridneva, M.V. Martynenko. Kharkiv National University bу V.N. Karazin. Volumes of work of the family doctor include diagnostics, treatment, multifactorial prevention of diseases of internal organs, which do not require treatment in the hospital. Diseases of the biliary system are one of the leading…

The role and place of ghrelin in the pathology of diseases of the gastrointestinal tract

A.A. Kudryavtsev Kharkiv Medical Academy of Postgraduate Education To date, diseases of the digestive system remain one of the most pressing problems of modern medicine. Much attention is paid to the biochemical and molecular mechanisms underlying the development of these pathologies. In recent years, new hormones and neurotransmitters have been discovered that regulate energy metabolism…

Assessment of fetuin-A in patients with comorbidity of non-alcoholic fatty liver disease and arterial hypertension

Ass.prof. К.О. Prosolenko Kharkiv National Medical University The aim of our study was to investigate serum fetuin A levels in patients with NAFLD and its comorbidity with essential hypertension or renoparenchymal hypertension, as well as to evaluate the association of this indicator with the major pathogenetic factors of these diseases. All patients were divided into…