Indicators of immunity and functional state of the central nervous system with chronic acquired toxoplasmosis

Prof. Bodnіa K.I., Tanchuk Yu.V.

Kharkiv National Medical University

KNP ChOR Regional Clinical Infectious Disease Hospital

For the first time, patterns of changes in the ratio of immunity indicators were revealed in chronic acquired toxoplasmosis — leukocyte intoxication index (LII), CD3, immunoregulatory index (IRI), total immunoglobulins, adaptive and compensatory reactions (tension coefficient) and functional state of the central nervous system (CNS) — changes in electroencephalographic research (EEG) according to the stem-diencephalic type — with the help of available informative methods, which allowed to assess the severity of the course, plan treatment and predict the outcome of the disease, without resorting to complex research methods. It has been established that the host-parasite relationship and clinical manifestations in chronic acquired toxoplasmosis largely depend on the protective and adaptive reactions and compensatory capabilities of the human body.

Keywords: toxoplasmosis, indicators of immunity, central nervous system, adaptive responses, compensatory possibilities, host-parasite relations.

https://doi.org/10.15407/internalmed2023.01.051

Download.PDF (ukr)

Cite:

Бодня, К.І. Показники імунітету і функціонального стану центральної нервової системи при хронічному набутому токсоплазмозі / К.І. Бодня, Ю.В. Танчук // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2023. – № 1. – С. 51-55. doi: 10.15407/internalmed2023.01.051

Bodnіa KI, Tanchuk YuV. Pokaznyky imunitetu i funktsionalnoho stanu tsentralnoi nervovoi systemy pry khronichnomu nabutomu toksoplazmozi [Indicators of immunity and functional state of the central nervous system with chronic acquired toxoplasmosis]. Shidnoevr. z. vnutr. simejnoi med. 2023;1:51-55. Ukrainian. doi: 10.15407/internalmed2023.01.051

References

  1. Chemoh W, Sawangjaroen N, Nissapatorn V, Suwanrath C, Chandeying V, Hortiwakul T, Andiappan H, Sermwittayawong N, Charoenmak B, Siripaitoon P, Lekkla A, Sukthana Y. Toxoplasma gondii infection: What is the real situation?. Experimental Parasitology. 2013;135(4):685-689. http://dx.doi.org/10.1016/j.exppara.2013.10.001
  2. Abd El-Rehim El-Henawy A, Abdel-Razik A, Zakaria S, Elhammady D, Saudy N, Azab M. Is toxoplasmosis a potential risk factor for liver cirrhosis?. Asian Pacific Journal of Tropical Medicine. 2015;8(10):784-791. http://dx.doi.org/10.1016/j.apjtm.2015.09.003
  3. Colosi H. Influence of Toxoplasma gondii Infection on Male Fertility: A Pilot Study on Immunocompetent Human Volunteers. Iran J Parasitol. 2015;10(3):402–409.
  4. Dalimi A. Latent Toxoplasmosis and Human. AbdoliIranian. J Parasitol. 2012;7(1):1–17.
  5. Dukaczewska A, Tedesco R, Liesenfeld O. Experimental models of ocular infection with<i>Toxoplasma gondii</i>. European Journal of Microbiology and Immunology. 2015;5(4):293-305. http://dx.doi.org/10.1556/1886.2015.00045
  6. Ferreira A. Risk factors for ocular toxoplasmosis in Brazil. Epidemiology and Infection. 2013;142(1):142-148. http://dx.doi.org/10.1017/s0950268813000526
  7. Bodnia KI. Porushennia protsesiv adaptatsii ta yikh korektsiia pry khronichnomu opystorkhozi. Avtoref. dys… d-ra med. nauk: 14.01.13. Kyivskyi naukovo-doslidnyi instytut epidemiolohii ta infektsiinykh khvorob imeni L.V. Hromashevskoho. Kyiv; 1999. 42 р. Ukrainian
  8. Bonfá G, Benevides L, Souza M, Fonseca D, Mineo T, Rossi M, Silva N, Silva J, de Barros Cardoso C. CCR5 Controls Immune and Metabolic Functions during Toxoplasma gondii Infection. PLoS ONE. 2014;9(8):e104736. http://dx.doi.org/10.1371/journal.pone.0104736
  9. Dlugonska H. Immunity in Toxoplasma gondii infections. Post. Hig. Med. Dosw. 2000;54:53–65.
  10. Flatt A, Shetty N. Seroprevalence and risk factors for toxoplasmosis among antenatal women in London: a re-examination of risk in an ethnically diverse population. The European Journal of Public Health. 2012;23(4):648-652. http://dx.doi.org/10.1093/eurpub/cks075
  11. Pohoden’ko-Chudakova IO, Surin AV. Integral’nye indeksy intoksikacii pri odontogennyh sinusitah verhnecheljustnoj pazuhi. Sovremennoe sostojanie voprosa. (Analiticheskij obzor literatury).Eksperymentalna ta klinichna stomatolohiia. 2018;2 (3):15–18. Russian
  12. Surin AV, Pohoden’ko-Chudakova I.O.Informativnost’ integral’nyh indeksov intoksikacii u pacientov s hronicheskim odontogennym sinusitom verhnecheljustnoj pazuhi. Ukraїns’kij zhurnal medicini, bіologії ta sportu. Tom 3;6 (15):234–239. Russian https://doi.org/10.26693/jmbs03.06.234
  13. Ambarcumjan RG, Bekbergenov BM. Opredelenie lejkocitarnogo indeksa intoksikacii v preparatah krovi s zonoj suhogo krasitelja. Lab. delo. 1986;9:534–535. Russian
  14. Siplivyj VA, Kon’ EV, Evtushenko DV. Ispol’zovanie lejkocitarnyh indeksov dlja prognozirovanija ishoda peritonita. Klіnіchna hіrurgіja. 2009;9:21–26. Russian
  15. Kudratova N, Umarova M, Dzhurabekova A, Abdullaeva N. Jelektrojencefalografija v norme i pri jepilepsii v razlichnyh vozrastnyh gruppah. Zhurnal problemy biologii i mediciny. 2017;4(97):56–60. Russian. Availanble from: https://inlibrary.uz/index.php/problems_biology/article/ view/3269
  16. Kumar G, Mahadevan A, Guruprasad A, Kovoor J, Satishchandra P, Nath A, Ranga U, Shankar S. Eccentric target sign in cerebral toxoplasmosis: Neuropathological correlate to the imaging feature. Journal of Magnetic Resonance Imaging. 2010;31(6):1469-1472. http://dx.doi.org/10.1002/jmri.22192
  17. Genes VS. Nekotorye prostye metody kiberneticheskoj obrabotki dannyh diagnosticheskih i fiziologicheskih issledovanij. M.: Nauka; 1967. 208 р. Russian