Assessment of Brain Deep White Matter Hyperintensities in Smokers in Azerbaijan

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Lala Guluzade1,2, Prof. Malakhat Sultanova1, Kamran Yakubov 3, PHD Hasan Isayev 2, Aygul Nadirova 4, Ulviyya Ismayılova 5

1 Azerbaijan Medical University Educational-Surgical Clinic
2 Zafaran hospital, Baku, Azerbaijan
3 Central Clinic Hospital, Baku, Azerbaijan
4 Baku Health Center
5 Sahhat German-Azerbaijani Medical center, Baku, Azerbaijan

Abstract. Bacground: T2 hyperintense foci (white matter hyperintensities) are seen in the white matter of the brain on magnetic resonance imaging (MRI) in smokers. The aim of the study is to reveal the relationship, number and size of these white matter hyperintensities with smoking in Azerbaijani smoking men and to compare them with the control group. Materials and Methods: Total of 120 patients between 37 and 70 years were included in this study. The mean age was 50,2±0,8. Eighty(80) of the patients were smokers and 40 of them was healthy individuals. In our study we exam the location(according to the brain lobes), size and frequency of T2 hyperintense foci on MRI. We used 1.5-Tesla Magnetom Aera MRI equipment and images obtained with T2 turbo inversion recovery magnitude (TIRM) sequences. MRI images were obtained using TR-9200, TI 2450, TE 84 and 3.5 mm slice thickness, and 10% interslice gap. Results: The mean age of the smokers was 50,7±1,0 (37-70) years. The mean age of the healthy individuals was 49±1,1(39-62) (Pu=0,556). WMH was not found in 21(52,5%) patient from 40 healthy individuals. The average number of WMH detected in 47.5%(19) of patients was 3.2±0,8 (min0-max20) and the average size was 1.9±0,1 mm (min1.5-max 2.5). According to the measurements and numbers performed on 80 smokers included in the study, the average number of WMHs was 8.8±1,5(min0-max70) and the average size was 2.3±1,0 mm(min1.5-max6). At the same time, WMHs were not observed in 28 (35,0%) smokers. It was found that the number of WMH in smokers was higher than in control group-healthy individuals(Pu=0,025). But the size of WMH in smokers was not differ so much than in healthy individuals(Pu=0,459). Conclusion: An increase in the number of white matter hyperintensities in the brain was found in smoking men in Azerbaijan compared to the healthy individuals. There was no significant difference in the statistically correct correlation (in the number and size of the WMH) between those who had smoked for longer years-50 years and those who had smoked the least-15 years. The number of WMH increases with age, regardless of whether the patient smokes or not.

Key words: MRI, white matter hyperintensities, smoking

https://dx.doi.org/10.15407/internalmed2022.02.025

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Для цитування:

  1. Guluzade, L. Assessment of Brain Deep White Matter Hyperintensities in Smokers in Azerbaijan / L. Guluzade, M. Sultanova, K. Yakubov, H. Isayev, A. Nadirova, U. Ismayılova // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2022. – № 2. – С. 25-31. doi: 15407/internalmed2022.02.025
  2. Guluzade L, Sultanova M, Yakubov K, Isayev H, Nadirova A, Ismayılova U. [Assessment of Brain Deep White Matter Hyperintensities in Smokers in Ukraine]. Shidnoevr. z. vnutr. simejnoi med. 2022;2:25-31. doi: 10.15407/internalmed2022.02.025

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