The role of dipeptidylpeptidase-4 inhibitors in the current therapy of type 2 diabetes mellitus.

Prof. L.V. Zhuravlyova, M.V. Filonenko.

Kharkiv National Medical University.

Recent advances in the study of the pathogenesis of type 2 diabetes, including the mechanisms of regulation of postprandial blood glucose level, have led to the emergence of new treatment strategies aimed at overcoming dysfunction of the Langerhans islands, including those that affect the incretine hormones of the intestines. Dipeptidylpeptidase-4 inhibitors are a relatively new class of oral hypoglycemic drugs. The inhibition of the destruction of the incretin hormone — glucagon-like peptide-1 — has a positive effect on glucose metabolism, which includes both potentiation of glucose-induced increase of insulin level and inhibition of glucagon secretion. An absence of significant side effects and lack of influence on bodyweight, low risk of hypoglycemia positively distinguish the class of dipeptidyl peptidase-4 inhibitors from other groups of oral hypoglycemic drugs.

Key Words: type 2 diabetesmellitus, dipeptidylpeptidase-4 inhibitors, vildagliptin.


For citing:

1. Журавльова, Л.В. Роль інгібіторів дипептиділпептидази-4 в сучасній терапії цукрового діабету 2 типу /Л.В. Журавльова, М.В. Філоненко // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2020. – № 2. – С. 80-84. doi: 10.15407/internalmed2020.02.080.
2. Zhuravlyova LV, Filonenko MV. [The role of dipeptidylpeptidase-4 inhibitors in the current therapy of type 2 diabetes mellitus]. Shidnoevr. z. vnutr. simejnoi med. 2020;2:80-84. Ukrainian. doi: 10.15407/internalmed2020.02.080.


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