Clinical and paraclinical data of the efficacy of metabolic group drugs using in the complex treatment of the patients with long-term consequences after mild closed traumatic brain injury.

MD, PhD Y. Lekomtseva

State Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine, Department of Neurology, Department of Functional Neurosurgery and Paroxysmal States

To evaluate the clinical and paraclinical data of the efficacy of metabolic group drugs using in the complex treatment of the patients with long-term consequences after closed mild traumatic brain injury.

Materials and methods: Forty-two patients with long-term consequences after closed mild traumatic brain injury (1 group) were investigated with mean age 35,66±11,08 years, 18 women and 24 men whom additionally were added the following complex: ethylmethylhydroxypyridine succinate 100 mg intramuscular every day (28 days) together with cholin alfosceras 250 mg intramuscular every day (14 days). Control group — 39 patients with long-term consequences after mild brain traumatic injury (2 group) who didn’t receive the proposed complex with the mean age of 30,29±9,24 years; 16 women and 23 men. Clinical and neurological investigations were performed, vegetative functional state was evaluated by standard tests.

Results: It was noted the positive influence of metabolic group drugs in treatment of the severity of vegetative disturbances: before treatment according to vegetative scale data in 1 gr. was 42±2,3 points, after treatment — 21,8±1,9; 2 gr. accordingly, 45±4,6 and 33,8±3,1 (p<0,05). During investigation of vegetative tonus in 35 patients (83.33%) from 1 gr. Statistically (p<0,05) decreasing of the sympathic tonus in parameters was found which were higher before treatment.

During investigation of vegetative reactivity it was registered the statistical (p<0,05) normalization of vegetative reactivity data in patients from 1 gr. Positive dynamics of cephalgia syndrome was noted in 70% patients from 1 gr. (r=0.03; р<0,05) compare to the patients from 2 gr. Using of metabolic drugs showed the increasing of cases of positive dynamics in psychiatric changes on 80% (р<0,05) manifesting in stable mood improvement, decreasing of irritation and anxiety, increasing of mental capacity, memorization improvement. It was found the intensive of clinical improvement in sleep quality in 83% patients from the main group which is on 70% higher compare to the patients from the comparison group (p<0,05).

Conclusion: Metabolic profile drugs in the patients with longterm consequences after traumatic brain injury showed high clinical efficacy in correction of vegetative dystonia syndrome, dyssomnia and cephalgia syndromes.

Key Words: long-term consequences after mild closed brain traumatic injury, metabolic group drugs.

https://dx.doi.org/10.15407/

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