Features of insulin therapy in patients with type 1 diabetes mellitus during pregnancy

Prof. Zhuravlyova LV, Rogachova TA Kharkiv National Medical University.

Until recently, pregnancy in type 1 diabetes mellitus caused high risk of complications for the mother and severe congenital abnormalities for the child. The main problems of pregnant women with diabetes were difficulties in achieving stable normal blood glucose level, avoiding hypoglycemia and ketoacidosis. Control of DM-1 during pregnancy is significantly complicated by the addition of physiological insulin resistance. In connection with hormonal changes, the need for insulin and insulin sensitivity vary significantly during different periods of pregnancy. The degree of expression of these changes is individual. During the last 10 years, there has been significant progress in the level of knowledge about the patterns of the course of DM-1 in pregnancy, also in methods of blood glucose monitoring and insulin delivery. Synthetic insulin analogues were developed and introduced into practice. After carefully studying the latest scientific evidence based data, we reviewed the latest advances in the treatment of diabetes type 1 in pregnant women.

Key words: pregnancy, diabetes mellitus type 1, blood glucose monitoring, insulin pump, insulin analogues.

https://dx.doi.org/10.15407/internalmed2018.01.078
Zhuravleva LV, Rogacheva TA. [Features of insulin therapy in patients with type 1 diabetes mellitus during pregnancy]. Shidnoevr. z. vnutr. simejnoi med. 2018;1:78-84. Russian.

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