Immunohistochemical features for prognosis of epithelialmesenchymal transformation and stem cell phenotype of small cell lung cancers

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Prof. Irina Yakovtsova1, PhD Oleksandr Yanchevskyi2

1 Kharkiv National Medical University

2 Luhansk State Medical University (Rivne)

Small cell lung cancer (SCLC) is one of the most aggressive tumor of the human body and has morphological features of cancers with epithelial-mesenchymal transformation (EMT). The aim of our study to improve morphological features for SCLC course prediction based on researching of EMT and stem cells phenotype at the molecular-biological level. The prognostic significance of pancytokeratin, vimentin, E-cadherin and N-cadherin expression, EMT stage and expression of CD44 for overall survival and their influence on the spread of the tumor were established. It was proved that the presence of EMT is associated with extensive forms of SCLC (p < 0.01), the overall survival of patients with SCLC depended on the presence of EMT (p < 0.01) and its stage (p < 0.01).

Keywords: small cell lung cancer, epithelial-mesenchymal transformation, CD44.

https://doi.org/10.15407/internalmed2023.01.092

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Яковцова, І.І. Імуногістохімічні критерії прогнозу епітеліально-мезенхімальної трансформації та стовбурового фенотипу дрібноклітинних раків легень / І.І. Яковцова, О.В. Янчевський // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2023. – № 1. – С. 92-96. doi: 10.15407/internalmed2023.01.092

Yakovtsova ІІ, Yanchevskyi OV. Imunohistokhimichni kryterii prohnozu epitelialno-mezenkhimalnoi transformatsii ta stovburovoho fenotypu dribnoklitynnykh rakiv lehen  [Immunohistochemical features for prognosis of epithelialmesenchymal transformation and stem cell phenotype of small cell lung cancers]. Shidnoevr. z. vnutr. simejnoi med. 2023;1:92-96. Ukrainian. doi: 10.15407/internalmed2023.01.092

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