Miloslavsky D.K.
Government Institution “L.T. Malaya Therapy National Institute of the NAMS of Ukraine”, Kharkiv, Ukraine.
The historical review provides data on the formation of ideas about the group of biologically active drugs – probiotics, starting with the ideas of our fellow countryman and Nobel laureate (1908) Ilya Ilyich Mechnikov. The authors consider the mechanisms of action of probiotics, their classification, effectiveness in conditions of various therapeutic pathologies, discuss the prospects for the appointment and issues of safety of probiotic drugs. Possible mechanisms by which the components of the microbiota increase blood pressure (BP), affect the levels of lipids and glucose, cause the progression of the components of the metabolic syndrome and the possibility of their correction with the use of probiotics are presented.
Key Words: I.I. Mechnikov, probiotics, mechanisms of action, classification, metabolic syndrome, historical review
https://dx.doi.org/10.15407/internalmed2020.02.109
For citing:
1. Милославський, Д.К. Пробіотики: від Іллі Мечникова до сьогодення (до 175-річчя від народження І.І. Мечникова // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2020. – № 2. – С. 109-115. doi: 10.15407/internalmed2020.02.109.
2. Miloslavsky DK. [Probiotics: from Ilya Mechnikov to the present days (to the 175-th anniversary of the birth of I.I. Mechnikov)]. Shidnoevr. z. vnutr. simejnoi med. 2020;2:109-115. Ukrainian. doi: 10.15407/internalmed2020.02.109.
References:
- Shokryazdan P, Faseleh Jahromi M, Liang J, Ho Y. Probiotics: From Isolation to Application. Journal of the American College of Nutrition. 2017;36(8):666-676. http://dx.doi.org/10.1080/07315724.2017.1337529
- Liong M. Probiotics: A Critical Review of Their Potential Role as Antihypertensives, Immune Modulators, Hypocholesterolemics, and Perimenopausal Treatments. Nutrition Reviews. 2008;65(7):316-328. http://dx.doi.org/10.1111/j.1753-4887.2007.tb00309.x
- Mechnikov II.Études sur la nature humaine (1903) Jetjudy o prirode cheloveka . 4-e izd. Moskow; 1913. Russian.
- Mechnikov II. Jetjudy optimizma. Parizh, 13/26 maja 1907, 216 р. Russian.
- Kovaljova AA, Velikaja. I.I. Mechnikov – osnovatel’ teorii starenija i uchenija o probiotikah. Problemy starenija i dolgoletija. 2016. Tom 25, N 1. Р 11-22 . Russian.
- Bachynsjka OA. Mechnykov Illja Illich / .Encyklopedija istoriji Ukrajiny: u 10 t. Smolij VA, editor. Instytut istoriji Ukrajiny NAN Ukrajiny. Kyiv: Nauk. Dumka; 2009. T. 6 : La Mi. Р 631. ISBN 978-966-00-1028-1.
- McGuire M, McGuire M. Human Milk: Mother Nature’s Prototypical Probiotic Food?. Advances in Nutrition. 2015;6(1):112-123. http://dx.doi.org/10.3945/an.114.007435
- Brown H. Ilya Mechnikov and His Studies on Comparative Inflammation. Experimental Biology and Medicine. 1995;209(2):99-101. http://dx.doi.org/10.3181/00379727-209-43884a
- McGonagle D, Georgouli T. The Importance of Mechnikovs Thorn for an Improved Understanding of 21st Century Medicine and Immunology: A View from the Eye. Scandinavian Journal of Immunology. 2008;68(2):129-139. http://dx.doi.org/10.1111/j.1365-3083.2008.02114.x
- Miyazaki T. Homage to Mechnikov – the phagocytic system: past and present. Seminars in Immunopathology. 2018;40(6):519-521. http://dx.doi.org/10.1007/s00281-018-0719-4
- Scarpellini E, Cazzato A, Lauritano C, Gabrielli M, Lupascu A, Gerardino L, Abenavoli L, Petruzzellis C, Gasbarrini G, Gasbarrini A. Probiotics: Which and When?. Digestive Diseases. 2008;26(2):175-182. http://dx.doi.org/10.1159/000116776
- Senok A, Ismaeel A, Botta G. Probiotics: facts and myths. Clinical Microbiology and Infection. 2005;11(12):958-966. http://dx.doi.org/10.1111/j.1469-0691.2005.01228.x
- Vasile N, Ghindea R, Vassu T. Probiotics-an alternative treatment for various diseases. Roum Arch Microbiol Immunol. 2011;70(2):54-59.
- Gupta V, Garg R. Probiotics. Indian Journal of Medical Microbiology. 2009;27(3):202. http://dx.doi.org/10.4103/0255-0857.53201
- Huys G, Botteldoorn N, Delvigne F, De Vuyst L, Heyndrickx M, Pot B, Dubois J, Daube G. Microbial characterization of probiotics-Advisory report of the Working Group “8651 Probiotics” of the Belgian Superior Health Council (SHC). Molecular Nutrition & Food Research. 2013;57(8):1479-1504. http://dx.doi.org/10.1002/mnfr.201300065
- Huys G, Botteldoorn N, Delvigne F, De Vuyst L, Heyndrickx M, Pot B, Dubois J, Daube G. Microbial characterization of probiotics-Advisory report of the Working Group “8651 Probiotics” of the Belgian Superior Health Council (SHC). Molecular Nutrition & Food Research. 2013;57(8):1479-1504. http://dx.doi.org/10.1002/mnfr.201300065
- de Vrese M, Schrezenmeir J. Probiotics, Prebiotics, and Synbiotics. Food Biotechnology. 2008;:1-66. http://dx.doi.org/10.1007/10_2008_097
- Aguilar A. Microbiota under pressure. Nature Reviews Nephrology. 2016;13(1):3-3. http://dx.doi.org/10.1038/nrneph.2016.173
- Sudha R, Upadrasta A. Probiotics and blood pressure: current insights. Integrated Blood Pressure Control. 2016;:33. http://dx.doi.org/10.2147/ibpc.s73246
- Kobyliak N, Falalyeyeva T, Boyko N, Tsyryuk O, Beregova T, Ostapchenko L. Probiotics and nutraceuticals as a new frontier in obesity prevention and management. Diabetes Research and Clinical Practice. 2018;141:190-199. http://dx.doi.org/10.1016/j.diabres.2018.05.005
- Kobyliak N, Falalyeyeva T, Boyko N, Tsyryuk O, Beregova T, Ostapchenko L. Effect of alive probiotic on insulin resistance in type 2 diabetes patients: Randomized clinical trial. Diabetes Metab Syndr. 2018;12(5):617-624. doi:10.1016/j.dsx.2018.04.015
- Plaza-Diaz J, Ruiz-Ojeda F, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Advances in Nutrition. 2019;10(suppl_1):S49-S66. http://dx.doi.org/10.1093/advances/nmy063
- Adams C. The probiotic paradox: live and dead cells are biological response modifiers. Nutrition Research Reviews. 2010;23(1):37-46. http://dx.doi.org/10.1017/s0954422410000090
- Toscano M, De Grandi R, Pastorelli L, Vecchi M, Drago L. A consumer’s guide for probiotics: 10 golden rules for a correct use. Digestive and Liver Disease. 2017;49(11):1177-1184. http://dx.doi.org/10.1016/j.dld.2017.07.011
- Roberfroid M, Gibson G, Hoyles L, McCartney A, Rastall R, Rowland I, Wolvers D, Watzl B, Szajewska H, Stahl B, Guarner F, Respondek F, Whelan K, Coxam V, Davicco M, Léotoing L, Wittrant Y, Delzenne N, Cani P, Neyrinck A, Meheust A. Prebiotic effects: metabolic and health benefits. British Journal of Nutrition. 2010;104(S2):S1-S63. http://dx.doi.org/10.1017/s0007114510003363
- Pimenta F, Luaces-Regueira M, Ton A, Campagnaro B, Campos-Toimil M, Pereira T, Vasquez E. Mechanisms of Action of Kefir in Chronic Cardiovascular and Metabolic Diseases. Cellular Physiology and Biochemistry. 2018;48(5):1901-1914. http://dx.doi.org/10.1159/000492511
- Scavuzzi B, Miglioranza L, Henrique F, Pitelli Paroschi T, Lozovoy M, Simão A, Dichi I. The role of probiotics on each component of the metabolic syndrome and other cardiovascular risks. Expert Opinion on Therapeutic Targets. 2015;19(8):1127-1138. http://dx.doi.org/10.1517/14728222.2015.1028361
- Chi C, Li C, Wu D, Buys N, Wang W, Fan H, Sun J. Effects of Probiotics on Patients with Hypertension: a Systematic Review and Meta-Analysis. Current Hypertension Reports. 2020;22(5):. http://dx.doi.org/10.1007/s11906-020-01042-4
- Lau, Neves, Ferreira-Magalhães, Carvalho, Freitas. Probiotic Ingestion, Obesity, and Metabolic-Related Disorders: Results from NHANES, 1999-2014. Nutrients. 2019;11(7):1482. http://dx.doi.org/10.3390/nu11071482
- Ferrarese R, Ceresola ER, Preti A, Canducci F. Probiotics, prebiotics and synbiotics for weight loss and metabolic syndrome in the microbiome era. Eur Rev Med Pharmacol Sci. 2018;22(21):7588-7605. doi: 10.26355/eurrev_201811_16301
- Gadelha C, Bezerra A. Efeitos dos probióticos no perfil lipídico: revisão sistemática. Jornal Vascular Brasileiro. 2019;18:. http://dx.doi.org/10.1590/1677-5449.180124
- Firouzi S, Majid H, Ismail A, Kamaruddin N, Barakatun-Nisak M. Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial. European Journal of Nutrition. 2016;56(4):1535-1550. http://dx.doi.org/10.1007/s00394-016-1199-8
- Bodnar PM, Jankovsjkyj DS, Dyment GhS. Probiotykoterapija cukrovogho diabetu typu 2: metodychni rekomendaciji. Kyjiv: Ukrmedpatentinform;2013. Р 24. Ukrainian.
- Sposib korekciji dyslipidemiji u khvorykh na cukrovyj diabet typu 2 z nealkogholjnoju zhyrovoju khvoroboju pechinky: pat. Ukrajiny # 80470; zajavl. 28.12.2012; opubl. 27.05.2013, Bjul. #10.
- Tsuji H, Nomoto K. Yakult Intestinal Flora-SCAN: A Novel Culture-Independent Analytical Method for Detection of Bacteria in the Bloodstream. Annals of Nutrition and Metabolism. 2017;71(1):4-10. http://dx.doi.org/10.1159/000479917
- Cai D, Zhu C, Chen S. Microbial production of nattokinase: current progress, challenge and prospect. World Journal of Microbiology and Biotechnology. 2017;33(5):. http://dx.doi.org/10.1007/s11274-017-2253-2
- Chen H, McGowan E, Ren N, Lal S, Nassif N, Shad-Kaneez F, Qu X, Lin Y. Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases. Biomarker Insights. 2018;13:. http://dx.doi.org/10.1177/1177271918785130
- Probiotika: Doch nicht nützlich? Cell Press. 07.09.2018. Available from: https://www.scinexx.de/news/medizin/probiotika-dochnicht-nuetzlich/
- Nashemu velikomu sootechestvenniku posvjashhaetsja. Laureat Nobelevskoj premii Il’ja Il’ich Mechnikov (1845- 1916). https://www.studies.danone.com,. http://danone.ua/ about-company/history/
- Myloslavsjkyj DK. Medyky-juviljary 2015 roku. Kuljturna spadshhyna Slobozhanshhyny; 2016, lypenj, chyslo 31. Р 122-147. Mechnykov I.I. р 133-138.