Prof. О.М. Korzh, Y.N. Fylenko.
Kharkiv Medical Academy of Postgraduate Education.
The article considers the pathogenesis of hypertension and the background of adipokine imbalance. Adipokines are directly involved in the mechanisms of blood pressure, atherogenesis, regulation of oxidative stress, blood clotting and the development of non-infectious inflammation. Despite the wide range of antihypertensive drugs on the pharmaceutical market, achieving the target blood pressure level remains a challenge. The main problem in the treatment of hypertension is the development of resistance to pharmacotherapy in patients. In the pathogenesis of the development of resistant hypertension, hyperproduction of adipokines and proinflammatory cytokines with increased rigidity of the main vessels plays an important role. That is why adipokines can be the implementers of the mechanism of adverse effects on the cardiovascular system. Studying their pathophysiological role may make them a therapeutic target in the fight against cardiovascular disease.
Key Words: adipokines, hypertension, cardiovascular diseases, atherosclerosis, leptin, resistin, omentin, visfatin.