Assoc. prof. O.L. Tondiy¹, prof. O. Yu. Sukhonosova¹, assoc. prof. S.M. Korenev¹, doctor O.V. Kunta²
¹Educational and Scientific Institute of Postgraduate Education of Kharkiv National Medical University, Department of Neurology and Pediatric Neurology
²Municipal Institution of the Lviv Regional Council «Educational and Rehabilitation Center “Levenya”»
The article summarizes the issues of modern classification, clinical course, manifestations, diagnostics and symptomatic treatment of hereditary diseases with predominant damage to the pyramidal tracts at the level of the spinal cord — spastic paraplegias
Key words: hereditary spastic paraplegias
https://doi.org/10.15407/internalmed2025.01.107
Cite:
Тондій О.Л., Сухоносова О.Ю., Коренєв С.М., Кунта О.В. Спадкові захворювання з переважним ураженням пірамідних шляхів — спастичні параплегії (клінічна лекція)/Східноєвропейський журнал внутрішньої та сімейної медицини. – 2025. – № 1. – С. 107-117. doi.org/10.15407/internalmed2025.01.107
Tondiy OL, Sukhonosova O Yu, Korenev SM, Kunta OV. Hereditary diseases with predominantly affecting pyramidal pathways — spastic paraplegia (clinical lecture). Shidnoevropejskij Zurnal Vnutrisnoi Ta Simejnoi Medicini. 2025(1):107-117. doi.org/10.15407/internalmed2025.01.107
References:
- Faber I, Pereira E, Martinez A, Franca M, Teive H. Hereditary spastic paraplegia from 1880 to 2017: an historical review. Arq Neuropsiquiatr. 2017 Nov;75(11):813-8. https://doi.org/10.1590/0004-282×20170160
- Tesson C, Koht J, Stevanin G. Delving into the complexity of hereditary spastic paraplegias: how unexpected phenotypes and inheritance modes are revolutionizing their nosology. Hum Genet. 2015 Jun;134(6):511-38. https://doi.org/10.1007/s00439-015-1536-7
- Ruano L, Melo C, Silva MC, Coutinho P. The global epidemiology of hereditary ataxia and spastic paraplegia: a systematic review of prevalence studies. Neuroepidemiology. 2014;42:174-83. https://doi.org/10.1159/000358801
- Agosta F, Scarlato M, Spinelli EG. Hereditary Spastic Paraplegia: Beyond Clinical Phenotypes toward a Unified Pattern of Central Nervous System Damage. Radiology. 2015 Jul;276(1):207-18. https://doi.org/10.1148/radiol.14141715
- Koh K, Ishiura H, Tsuji S, Takiyama Y. JASPAC: Japan Spastic Paraplegia Research Consortium. Brain Sci. 2018 Aug 13;8(8):358-67. https://doi.org/10.3390/brainsci8080153
- Adams R.D., Victor M. Degenerative diseases of the nervous system. In: Principles of neurology. 5.ed. Eds. R.D.Adams, M.Victor. 1993; 997-999.
- Boustany R.N., Fleishnick E., Alper C.A. et al. The autosomal dominant form of «pure» familial spastic paraplegia. Neurology. 1987; 37; 910-915. https://doi.org/10.1212/WNL.37.6.910
- Boustany R.N. Hereditary spastic paraplegias. In: Brain’s Diseases of the nervous System. 10 ed. Ed. J.Walton. 1993; 442-443.
- McDermott C., White K., Bushby K. et al. Hereditary spastic paraparesis: a review of new developments. Journal Neurology, Neurosurgery, Psychiatry. 2000; 69; 150-160. https://doi.org/10.1136/jnnp.69.2.150
- Parsons C.G., Danysz W., Bartmann A. et al. Neuropharmacology. 1999;38:85–108. https://doi.org/10.1016/S0028-3908(98)00161-0
- Reid E. The hereditary spastic paraplegias. J. Neurol. 1999; 246; 995-1003. https://doi.org/10.1007/s004150050503
- Tandan R. Disorders of the upper and lower motor neurons. In: Neurology in clinical practice. 2ed. Eds. W.G.Bradley et al. 1996; 2; 1823-1852.
- Ardolino G, Bocci T, Nigro M. Spinal direct current stimulation (tsDCS) in hereditary spastic paraplegias (HSP): a sham-controlled crossover study. J Spinal Cord Med. 2018 Dec;3:1-8. https://doi.org/10.1080/10790268.2018.1543926