Antioxidant system: norm and pathology

Prof. L.M. Pasiyeshvili, prof. N.M. Zhelezniakova, as. prof. T.M. Pasiieshvili

Kharkiv National Medical University

The atricle presents modern data on the composition and role of the antioxidant system in the human body.The stages and components of the system (enzymatic and non-enzymatic) are considered, classifications are given. Its participation in the pathogenesis of diseases and the progression of diseases has been proven.

Key Words: antioxidant system, composition, classification, role in the body.

https://dx.doi.org/10.15407/internalmed2021.01.040

Download.PDF (rus)

For citing:

1. Пасиешвили, Л.М., Железнякова, Н.М., Пасиешвили, Т.М. Антиоксидантная система в норме и при патологии // Східноєвропейський журнал внутрішньої та сімейної медицини. – 2021. – №1. – С. 40-46. doi: 15407/internalmed2021.01.040

2. Pasiyeshvili LM, Zhelezniakova NM, Pasiyeshvili TM. [Antioxidant system: norm and pathology]. Shidnoevr. z. vnutr. simejnoi med. 2021;1:40-46. Russian. doi: 10.15407/internalmed2021.01.040

References:

1. Foyer C, Noctor G. Redox Homeostasis and Antioxidant Signaling: A Metabolic Interface between Stress Perception and Physiological Responses. The Plant Cell. 2005;17(7):1866-1875. http://dx.doi.org/10.1105/tpc.105.033589
https://doi.org/10.1105/tpc.105.033589

2. Elmore S. Apoptosis: A Review of Programmed Cell Death. Toxicologic Pathology. 2007;35(4):495-516. http://dx.doi.org/10.1080/01926230701320337
https://doi.org/10.1080/01926230701320337

3. Tan B, Norhaizan M, Liew W, Sulaiman Rahman H. Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. Frontiers in Pharmacology. 2018;9:. http://dx.doi.org/10.3389/fphar.2018.01162
https://doi.org/10.3389/fphar.2018.01162

4. Dasgupta A, Klein K. Oxidative Stress Caused by Cigarette Smoking, Alcohol Abuse, and Drug Abuse. Antioxidants in Food, Vitamins and Supplements. 2014;:59-75. http://dx.doi.org/10.1016/b978-0-12-405872-9.00004-5
https://doi.org/10.1016/B978-0-12-405872-9.00004-5

5. Sun M, Jin H, Sun X, Huang S, Zhang F, Guo Z, Yang Y. Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy. Oxidative Medicine and Cellular Longevity. 2018;2018:1-17. http://dx.doi.org/10.1155/2018/3804979
https://doi.org/10.1155/2018/3804979

6. Phaniendra A, Jestadi D, Periyasamy L. Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases. Indian Journal of Clinical Biochemistry. 2014;30(1):11-26. http://dx.doi.org/10.1007/s12291-014-0446-0
https://doi.org/10.1007/s12291-014-0446-0

7. Ha H. Oxidative stress and antioxidants in hepatic pathogenesis. World Journal of Gastroenterology. 2010;16(48):6035. http://dx.doi.org/10.3748/wjg.v16.i48.6035
https://doi.org/10.3748/wjg.v16.i48.6035

8. Ighodaro O, Akinloye O. First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine. 2018;54(4):287-293. http://dx.doi.org/10.1016/j.ajme.2017.09.001
https://doi.org/10.1016/j.ajme.2017.09.001

9. Lukyanova L, Sukoyan G, Kirova Y. Role of Proinfl ammatory Factors, Nitric Oxide, and Some Parameters of Lipid Metabolism in the Development of Immediate Adaptation to Hypoxia and HIF-1α Accumulation. Bulletin of Experimental Biology and Medicine. 2013;154(5):597-601. http://dx.doi.org/10.1007/s10517-013-2008-5
https://doi.org/10.1007/s10517-013-2008-5

10. Li B, Pratt D. Methods for determining the efficacy of radical-trapping antioxidants. Free Radical Biology and Medicine. 2015;82:187-202. http://dx.doi.org/10.1016/j.freeradbiomed.2015.01.020
https://doi.org/10.1016/j.freeradbiomed.2015.01.020

11. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews. 2010;4(8):118. http://dx.doi.org/10.4103/0973-7847.70902
https://doi.org/10.4103/0973-7847.70902

12. Weydert C, Cullen J. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nature Protocols. 2009;5(1):51-66. http://dx.doi.org/10.1038/nprot.2009.197
https://doi.org/10.1038/nprot.2009.197

13. Dubinina EE. Produkty metabolizma kisloroda v funkcional’noj aktivnosti kletok. SPb.: Izd-vo Med. Pressa; 2006. 397 р. Russian

14. Mahanova RS. K voprosu izuchenija perekisnogo okislenija lipidov. Izvestija Orenburgskogo gosudarstvennogo agrarnogo universiteta. 2011;1(29-1):231-234. Russian

15. Gudkov SV, Bruskov VI, Kulikov AV. Bioantioksidanty (chast’ 1). Al’manah klinicheskoj mediciny.2014;1:61-65. Russian . doi.: org/10.18786/2072-0505-2014-31-61-65
https://doi.org/10.18786/2072-0505-2014-31-61-65

16. Fels J, Callies C, Kusche-Vihrog K, Oberleithner H. Nitric oxide release follows endothelial nanomechanics and not vice versa. Pflügers Archiv – European Journal of Physiology. 2010;460(5):915-923. http://dx.doi.org/10.1007/s00424-010-0871-8
https://doi.org/10.1007/s00424-010-0871-8

17. Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. Oxidative Stress, Prooxidants, and Antioxidants: The Interplay. BioMed Research International. 2014;2014:1-19. http://dx.doi.org/10.1155/2014/761264
https://doi.org/10.1155/2014/761264

18. Phaniendra A, Jestadi D, Periyasamy L. Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases. Indian Journal of Clinical Biochemistry. 2014;30(1):11-26. http://dx.doi.org/10.1007/s12291-014-0446-0
https://doi.org/10.1007/s12291-014-0446-0

19. Churnosov MI, Poljakova IS, Pahomov SР, Orlova VS. Molekuljarnye i geneticheskie mehanizmy biotransformacii ksenobiotikov. Nauchnye vedomosti belgorodskogo gosudarstvennogo universiteta. Serija: medicina. Farmacija. 2011;16(111):223- 228. Russian

20. Gaucher C, Boudier A, Bonetti J, Clarot I, Leroy P, Parent M. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants. 2018;7(5):62. http://dx.doi.org/10.3390/antiox7050062
https://doi.org/10.3390/antiox7050062

21. Pokrovskij VI, Vinogradov NA. Oksid azota, ego fiziologicheskie i patofiziologicheskie svojstva. Ter. arhiv. 2005;1:82-87. Russian

22. Pizzorno J. Glutathione!. Integr Med (Encinitas). 2014;13(1):8-12.

23. Kulinskij VI. Sistema glutationa. I. Sintez, transport, glutationtransferazy, glutationperoksidazy. Biomedicinskaja himija. 2009;55(3):255-277. Russian

24. Isheeva O. D. Klassifikacija sistemy antioksidantnoj zashhity kak osnova racional’noj organizacii jeksperimental’nogo issledovanija okislitel’nogo stressa u rastenij / O. D. Isheeva, E. V. Pradedova, R. K. Saljaev // Fiziologija rastenij. – 2011. – #58(2). – S.210-217. Russian

25. Kurutas E. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutrition Journal. 2015;15(1):. http://dx.doi.org/10.1186/s12937-016-0186-5
https://doi.org/10.1186/s12937-016-0186-5

26. Kolupaev JuE, Karpec JuV. Aktivnye formy kisloroda, antioksidanty i ustojchivost’ rastenij k dejstviju stressorov. Kiev: Logos; 2019. 277 р. Russian

27. Michiels C, Raes M, Toussaint O, Remacle J. Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress. Free Radical Biology and Medicine. 1994;17(3):235-248. http://dx.doi.org/10.1016/0891-5849(94)90079-5
https://doi.org/10.1016/0891-5849(94)90079-5

28. Rogozhin VV. Peroksidaza kak komponent antioksidantnoj sistemy zhivyh organizmov. SPb.: GIORD; 2004. 240 р. Russian

29. Chesnokova NP, Ponukalina EV, Bizenkova MN. Obshhaja harakteristika istochnikov obrazovanija svobodnyh radikalov i antioksidantnyh sistem. Uspehi sovrem. estestvoznanija. 2006;7:37-41. Russian

30. Zajcev VG, Ostrovskij OV, Zakrevskij VI. Svjaz’ mezhdu himicheskim stroeniem i mishen’ju dejstvija kak osnova dejstvija klassifikacii antioksidantov prjamogo dejstvija. Jeksperim. klin. farmakol. 2003;66:66-70. Russian

31. Polesskaja OG. Rastitel’naja kletka i aktivnye formy kisloroda. M.: Knizhnyj Dom Universitet; 2007. 140 р. Russian

32. Havinson VH, Barinov VA, Arutjunjan AV, Malinin VV. Svobodno-radikal’noe okislenie i starenie. SPb.: Nauka; 2003. 327 р. Russian

33. Lju BN, Efimov ML. Antioksidantnaja sistema kletki i kancerogenez. Uspehi sovrem. biol. 1976;82: 236-251. Russian

34. Borisova GG. Metody ocenki antioksidantnogo statusatrastenij. Ekaterinburg: Izd-vo Ural un-ta; 2012. 72 р. Russian

35. Pajares M, Cuadrado A, Engedal N, Jirsova Z, Cahova M. The Role of Free Radicals in Autophagy Regulation: Implications for Ageing. Oxidative Medicine and Cellular Longevity. 2018;2018:1-19. http://dx.doi.org/10.1155/2018/2450748
https://doi.org/10.1155/2018/2450748