{"id":4754,"date":"2026-04-26T20:11:48","date_gmt":"2026-04-26T18:11:48","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=4754"},"modified":"2026-05-15T22:09:11","modified_gmt":"2026-05-15T20:09:11","slug":"%d0%b4%d0%b8%d0%b2%d0%b5%d1%80%d1%82%d0%b8%d0%ba%d1%83%d0%bb%d1%8f%d1%80%d0%bd%d0%b0-%d1%85%d0%b2%d0%be%d1%80%d0%be%d0%b1%d0%b0-%d1%82%d0%b0-%d0%bc%d0%be%d0%b4%d1%83%d0%bb%d1%8f%d1%86%d1%96%d1%8f","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/4754","title":{"rendered":"Diverticular disease and gut microbiota modulation: a focus on probiotics"},"content":{"rendered":"<p><strong><b>Prof. O.I. Sergienko, assoc.prof. A.I. Chernobai, asp. G.Yu. Tegelska, ass\u043e\u0441.prof. A.I. Novokhatnya, \u00a0ass\u043e\u0441.prof.<\/b><\/strong><strong><b>\u00a0Yu.K. Sikalo<\/b><\/strong><\/p>\n<p><strong><b>Kharkiv National Medical University, Department of therapy, gastroenterology <\/b><\/strong><strong><b>and dieteti <\/b><\/strong><\/p>\n<p>The article presents a modern description of the phenotypes of diverticular disease.<\/p>\n<p>The risk factors of diverticular disease, the features of the course of the disease and the ethical role of the intestinal microbiota are highlighted.<\/p>\n<p>The feasibility of using probiotics and metabiotics based on short-chain fatty acids, butyrate and inulin in the treatment of diverticular disease is substantiated.<\/p>\n<p><strong><b>Key words:<\/b><\/strong>\u00a0diverticular disease, microbiota, probiotics, metabiotics<\/p>\n<p><strong>https:\/\/doi.org\/10.15407\/internalmed2026.01.087<\/strong><\/p>\n<p><strong><a href=\"http:\/\/www.internalmed-journal.in.ua\/wp-content\/uploads\/2026\/05\/\u0421\u041c_\u21161_2026_27_04_2026-87-91.pdf\">Download.PDF (ukr)<\/a><\/strong><\/p>\n<p><strong>Cite:<\/strong><\/p>\n<p>\u0421\u0435\u0440\u0433\u0456\u0454\u043d\u043a\u043e, \u041e.\u0406. \u0414\u0438\u0432\u0435\u0440\u0442\u0438\u043a\u0443\u043b\u044f\u0440\u043d\u0430 \u0445\u0432\u043e\u0440\u043e\u0431\u0430 \u0442\u0430 \u043c\u043e\u0434\u0443\u043b\u044f\u0446\u0456\u044f \u043a\u0438\u0448\u043a\u043e\u0432\u043e\u0457 \u043c\u0456\u043a\u0440\u043e\u0431\u0456\u043e\u0442\u0438: \u0430\u043a\u0446\u0435\u043d\u0442 \u043d\u0430 \u043f\u0440\u043e\u0431\u0456\u043e\u0442\u0438\u0447\u043d\u0456 \u0437\u0430\u0441\u043e\u0431\u0438 \/ \u041e.\u0406. \u0421\u0435\u0440\u0433\u0456\u0454\u043d\u043a\u043e, \u0410.\u0406. \u0427\u0435\u0440\u043d\u043e\u0431\u0430\u0439, \u0413.\u042e. \u0422\u0435\u0433\u0435\u043b\u044c\u0441\u044c\u043a\u0430, \u0410.\u0404. \u041d\u043e\u0432\u043e\u0445\u0430\u0442\u043d\u044f, \u042e.\u041a. \u0421\u0456\u043a\u0430\u043b\u043e \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. \u2014 2026. \u2014 \u2116 1. \u2014 \u0421. 87-91. doi: 10.15407\/internalmed2026.01.087<\/p>\n<p>Sergienko OI, Chernobai AI, Tegelska GYu, Novokhatnya AI, Sikalo YuK. Dyvertykuliarna khvoroba ta moduliatsiia kyshkovoi mikrobioty: aktsent na probiotychni zasoby [Diverticular disease and gut microbiota modulation: a focus on probiotics]. Shidnoevr. z. vnutr. simejnoi med. 2026;1:87-91. Ukrainian. doi: 10.15407\/internalmed2026.01.087<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>\n<p data-path-to-node=\"3,0,0\">Humes D, Lewis-Lloyd C. Diverticular disease. Medicine. 2024;52(5):279-283. <a class=\"ng-star-inserted\" href=\"https:\/\/doi.org\/10.1016\/j.mpmed.2024.02.006\" target=\"_blank\" rel=\"noopener\" data-hveid=\"0\" data-ved=\"0CAAQ_4QMahgKEwio_8PW1LuUAxUAAAAAHQAAAAAQtgc\">https:\/\/doi.org\/10.1016\/j.mpmed.2024.02.006<\/a><\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"3,1,0\">Williams S, Bjarnason I, Hayee B, Haji A. Diverticular disease: update on pathophysiology, classification and management. 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Microencapsulated sodium butyrate administered to patients with diverticulosis decreases incidence of diverticulitis &#8211; a prospective randomized study. Int J Colorectal Dis. 2014;29(3):387-393. <a class=\"ng-star-inserted\" target=\"_blank\" rel=\"noopener\" data-hveid=\"0\" data-ved=\"0CAAQ_4QMahgKEwio_8PW1LuUAxUAAAAAHQAAAAAQywc\">https:\/\/doi.org\/10.1007\/s00384-013-1807-5<\/a><\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"3,24,0\">Canani RB, Costanzo MD, Leone L, et al. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011;17(12):1519-1528. <a class=\"ng-star-inserted\" target=\"_blank\" rel=\"noopener\" data-hveid=\"0\" data-ved=\"0CAAQ_4QMahgKEwio_8PW1LuUAxUAAAAAHQAAAAAQzAc\">https:\/\/doi.org\/10.3748\/wjg.v17.i12.1519<\/a><\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"3,25,0\">Leonel AJ, Alvarez-Leite JI. Butyrate: implications for intestinal function. Curr Opin Clin Nutr Metab Care. 2012;15(5):474-479. <a class=\"ng-star-inserted\" target=\"_blank\" rel=\"noopener\" data-hveid=\"0\" data-ved=\"0CAAQ_4QMahgKEwio_8PW1LuUAxUAAAAAHQAAAAAQzQc\">https:\/\/doi.org\/10.1097\/MCO.0b013e32835665fa<\/a><\/p>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Prof. O.I. Sergienko, assoc.prof. A.I. Chernobai, asp. G.Yu. Tegelska, ass\u043e\u0441.prof. A.I. Novokhatnya, \u00a0ass\u043e\u0441.prof.\u00a0Yu.K. Sikalo Kharkiv National Medical University, Department of therapy, gastroenterology and dieteti The article presents a modern description of the phenotypes of diverticular disease. The risk factors of diverticular disease, the features of the course of the disease and the ethical role of&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,137],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":false,"content":false,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4754"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=4754"}],"version-history":[{"count":4,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4754\/revisions"}],"predecessor-version":[{"id":4822,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4754\/revisions\/4822"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=4754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=4754"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=4754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}