{"id":4734,"date":"2026-04-26T19:24:37","date_gmt":"2026-04-26T17:24:37","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=4734"},"modified":"2026-05-15T18:15:53","modified_gmt":"2026-05-15T16:15:53","slug":"%d0%b4%d1%96%d0%b0%d0%b3%d0%bd%d0%be%d1%81%d1%82%d0%b8%d1%87%d0%bd%d0%b0-%d1%82%d0%be%d1%87%d0%bd%d1%96%d1%81%d1%82%d1%8c-%d0%b7%d1%81%d1%83%d0%b2%d0%bd%d0%be%d1%85%d0%b2%d0%b8%d0%bb%d1%8c%d0%be%d0%b2","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/4734","title":{"rendered":"Diagnostic accuracy of shear wave elastography for staging liver fibrosis in diabetic patients with NAFLD"},"content":{"rendered":"<p><strong><b>V.N. Najafova <\/b><\/strong><\/p>\n<p><strong><b>Azerbaijan Medical University, Department of Radiation Diagnostics and Therapy <\/b><\/strong><\/p>\n<p>Aim. To assess the diagnostic accuracy of shear wave elastography for staging liver fibrosis in patients with diabetes mellitus and non-alcoholic fatty liver disease.<\/p>\n<p>Results. Our study demonstrates an increase in liver stiffness in diabetic patients with hepatic steatosis (p &lt; 0.05) . In the F0 + F1 subgroup, this increase was 49.6% . Our study has proven that transverse wave ultrasound elastography is a sufficiently informative method for determining the stages of liver fibrosis.<\/p>\n<p>Conclusion. Thus, elastography-based imaging techniques have the potential to substantially enhance both the screening and diagnostic evaluation of NAFLD in individuals with diabetes, thereby supporting more effective disease management . The Young\u2019s modulus value in the diagnosis of clinically significant fibrosis is 7.50 kPa.<\/p>\n<p><strong><b>Key words: <\/b><\/strong>nonalcoholic fatty liver disease, ultrasound, share wave elastometry, diagnostic value of the method, specificity, sensitivity.<\/p>\n<p><strong>https:\/\/doi.org\/10.15407\/internalmed2026.01.046<\/strong><\/p>\n<p><strong><a href=\"http:\/\/www.internalmed-journal.in.ua\/wp-content\/uploads\/2026\/05\/\u0421\u041c_\u21161_2026_27_04_2026-46-52.pdf\">Download.PDF (eng)<\/a><\/strong><\/p>\n<p><strong>Cite:<\/strong><\/p>\n<p>\u041d\u0430\u0434\u0436\u0430\u0444\u043e\u0432\u0430, \u0412.\u041d. \u0414\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u043d\u0430 \u0442\u043e\u0447\u043d\u0456\u0441\u0442\u044c \u0437\u0441\u0443\u0432\u043d\u043e\u0445\u0432\u0438\u043b\u044c\u043e\u0432\u043e\u0457 \u0435\u043b\u0430\u0441\u0442\u043e\u0433\u0440\u0430\u0444\u0456\u0457 \u0434\u043b\u044f \u0441\u0442\u0430\u0434\u0456\u044e\u0432\u0430\u043d\u043d\u044f \u0444\u0456\u0431\u0440\u043e\u0437\u0443 \u043f\u0435\u0447\u0456\u043d\u043a\u0438 \u0443 \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0456\u0432 \u0437 \u0434\u0456\u0430\u0431\u0435\u0442\u043e\u043c \u0442\u0430 \u041d\u0410\u0416\u0425\u041f \/ \u0412.\u041d. \u041d\u0430\u0434\u0436\u0430\u0444\u043e\u0432\u0430 \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. \u2014 2026. \u2014 \u2116 1. \u2014 \u0421. 46-52. English. doi: 10.15407\/internalmed2026.01.046<\/p>\n<p>Najafova VN. Diagnostic accuracy of shear wave elastography for staging liver fibrosis in diabetic patients with NAFLD. Shidnoevr. z. vnutr. simejnoi med. 2026;1:46-52. doi: 10.15407\/internalmed2026.01.046<\/p>\n<p><strong>References:<\/strong><\/p>\n<div id=\"model-response-message-contentr_c506faf915d2bf46\" class=\"markdown markdown-main-panel stronger enable-updated-hr-color\" dir=\"ltr\" aria-live=\"polite\" aria-busy=\"false\">\n<ol start=\"1\" data-path-to-node=\"0\">\n<li>\n<p data-path-to-node=\"0,0,0\">Han SK, Baik SK, Kim MY. Non-alcoholic fatty liver disease: definition and subtypes. Clin Mol Hepatol. 2023 Feb;29(suppl):S5-S16. doi: 10.3350\/cmh.2022.0424<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,1,0\">Younossi ZM, Koenig AB, Abdelatif D, et al. Global epidemiology of nonalcoholic fatty liver disease \u2014 meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73-84. https:\/\/doi.org\/10.1002\/hep.28431<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,2,0\">Pouwels S, Sakran N, Graham Y, et al. Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss. BMC Endocr Disord. 2022 Mar 14;22(1):63. doi: 10.1186\/s12902-022-00980-1<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,3,0\">Grander C, Grabherr F, Tilg H. Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options. Cardiovasc Res. 2023 Aug 7;119(9):1787-1798. doi: 10.1093\/cvr\/cvad095<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,4,0\">Westfall E, Jeske R, Bader AR. Nonalcoholic Fatty Liver Disease: Common Questions and Answers on Diagnosis and Management. Am Fam Physician. 2020 Nov 15;102(10):603-612<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,5,0\">Hydes TJ, Summers N, Brown E, et al. Mechanisms, screening modalities and treatment options for individuals with non-alcoholic fatty liver disease and type 2 diabetes. Diabet Med. 2020 Nov;37(11):1793-1806. doi: 10.1111\/dme.14356<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,6,0\">Ma C, Yang X, Zhang L, et al. BRCA1 regulates glucose and lipid metabolism in diabetes mellitus with metabolic dysfunction-associated steatotic liver disease via the PI3K\/Akt signaling pathway. PLoS One. 2025 Mar 26;20(3):e0318696. doi: 10.1371\/journal.pone.0318696<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,7,0\">Yin X, Guo X, Liu Z, Wang J. Advances in the Diagnosis and Treatment of Non-Alcoholic Fatty Liver Disease. Int J Mol Sci. 2023 Feb 2;24(3):2844. doi: 10.3390\/ijms24032844<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,8,0\">Ozturk A, Mohammadi R, Pierce TT, et al. Diagnostic Accuracy of Shear Wave Elastography as a Non-invasive Biomarker of High-Risk Non-alcoholic Steatohepatitis in Patients with Non-alcoholic Fatty Liver Disease. Ultrasound Med Biol. 2020 Apr;46(4):972-980. doi: 10.1016\/j.ultrasmedbio.2019.12.020<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,9,0\">Jiang H, Qin C, Xu Y-M. Feasibility of shear wave elastography for assessing steatosis in early-stage non-alcoholic fatty liver disease. PLoS One. 2025;20(5):e0324637. doi: 10.1371\/journal.pone.0324637<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,10,0\">Selvaraj EA, M\u00f3zes FE, Jayaswal ANA, et al. Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis. J Hepatol. 2021 Oct;75(4):770-785. doi: 10.1016\/j.jhep.2021.04.044<\/p>\n<\/li>\n<li>\n<p data-path-to-node=\"0,11,0\">Cazac G-D, L\u0103c\u0103tu\u0219u C-M, Mihai C, et al. Ultrasound-Based Hepatic Elastography in Non-Alcoholic Fatty Liver Disease: Focus on Patients with Type 2 Diabetes. Biomedicines. 2022;10(10):2375. doi: 10.3390\/biomedicines10102375<\/p>\n<\/li>\n<\/ol>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>V.N. Najafova Azerbaijan Medical University, Department of Radiation Diagnostics and Therapy Aim. To assess the diagnostic accuracy of shear wave elastography for staging liver fibrosis in patients with diabetes mellitus and non-alcoholic fatty liver disease. Results. Our study demonstrates an increase in liver stiffness in diabetic patients with hepatic steatosis (p &lt; 0.05) . In&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,137,138],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":false,"content":false,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4734"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=4734"}],"version-history":[{"count":4,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4734\/revisions"}],"predecessor-version":[{"id":4810,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4734\/revisions\/4810"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=4734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=4734"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=4734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}