{"id":4718,"date":"2026-04-26T19:11:33","date_gmt":"2026-04-26T17:11:33","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=4718"},"modified":"2026-05-15T17:35:06","modified_gmt":"2026-05-15T15:35:06","slug":"%d1%81%d1%83%d1%87%d0%b0%d1%81%d0%bd%d0%b5-%d1%80%d0%be%d0%b7%d1%83%d0%bc%d1%96%d0%bd%d0%bd%d1%8f-%d0%b5%d1%82%d1%96%d0%be%d0%bf%d0%b0%d1%82%d0%be%d0%b3%d0%b5%d0%bd%d0%b5%d0%b7%d1%83-%d1%82%d0%b0","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/4718","title":{"rendered":"Current understanding of etiopathogenesis and management of ischemic stroke"},"content":{"rendered":"<p><strong><b>Prof. O.E. Dubenko <\/b><\/strong><strong><sup><b>1<\/b><\/sup><\/strong><strong><b>, prof. O.A. Oparin <\/b><\/strong><strong><sup><b>2<\/b><\/sup><\/strong><strong><b>, assoc. prof. L.A. Sysun <\/b><\/strong><strong><sup><b>1<\/b><\/sup><\/strong><strong><b>\u00a0<\/b><\/strong><\/p>\n<p><strong><b>1 Kharkiv National Medical University, <\/b><\/strong><\/p>\n<p><strong><b>2 Ukrainian Humanitarian Institute <\/b><\/strong><\/p>\n<p>The article presents modern views on the etiopathogenesis of ischemic stroke, data on research and methods of its treatment, and discusses the issue of endovascular and drug thrombolysis.<\/p>\n<p>Preventive measures to reduce the risk of systemic complications in large stroke sizes are described. In addition to treatment tactics in the acute period of ischemic stroke, the paper shows the role of various methods of neurorehabilitation measures to restore motor activity of the limbs in patients who have suffered a stroke.<\/p>\n<p><strong><b>Key words:<\/b><\/strong>\u00a0acute ischemic stroke, cerebral hemodynamics, etiopathogenesis of ischemic stroke, systolic blood pressure, cerebral vessels.<\/p>\n<p><strong>https:\/\/doi.org\/10.15407\/internalmed2026.01.013<\/strong><\/p>\n<p><strong><a href=\"http:\/\/www.internalmed-journal.in.ua\/wp-content\/uploads\/2026\/05\/\u0421\u041c_\u21161_2026_27_04_2026-13-17.pdf\">Download.PDF (ukr)<\/a><\/strong><\/p>\n<p><strong>Cite:<\/strong><\/p>\n<p>\u0414\u0443\u0431\u0435\u043d\u043a\u043e, \u041e.\u0404. \u0421\u0443\u0447\u0430\u0441\u043d\u0435 \u0440\u043e\u0437\u0443\u043c\u0456\u043d\u043d\u044f \u0435\u0442\u0456\u043e\u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0443 \u0442\u0430 \u043c\u0435\u043d\u0435\u0434\u0436\u043c\u0435\u043d\u0442\u0443 \u0456\u0448\u0435\u043c\u0456\u0447\u043d\u043e\u0433\u043e \u0456\u043d\u0441\u0443\u043b\u044c\u0442\u0443 \/ \u041e.\u0404. \u0414\u0443\u0431\u0435\u043d\u043a\u043e, \u041e.\u0410. \u041e\u043f\u0430\u0440\u0456\u043d, \u041b.\u0410. \u0421\u0438\u0441\u0443\u043d \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. \u2014 2026. \u2014 \u2116 1. \u2014 \u0421. 13-17. doi: 10.15407\/internalmed2026.01.013<\/p>\n<p>Dubenko OE, Oparin OA, Sysun LA. Suchasne rozuminnia etiopatohenezu ta menedzhmentu ishemichnoho insultu [Current understanding of etiopathogenesis and management of ischemic stroke]. Shidnoevr. z. vnutr. simejnoi med. 2026;1:13-17. Ukrainian. doi: 10.15407\/internalmed2026.01.013<\/p>\n<p><strong>References:<\/strong><\/p>\n<p>1.Feigin VL, Brainin M, Norrving B, et al. World Stroke Organization: global stroke fact sheet 2025. Int J Stroke. 2025;20(2):132-44. https:\/\/doi.org\/10.1177\/17474930241308142<\/p>\n<p>2.Gasull T, Arboix A. Molecular mechanisms and pathophysiology of acute stroke: emphasis on biomarkers in the different stroke subtypes. Int J Mol Sci. 2022;23(16):9476.\u00a0https:\/\/doi.org\/10.3390\/ijms23169476<\/p>\n<p>3.Mead GE, Sposato LA, Sampaio Silva G, et al. A systematic review and synthesis of global stroke guidelines on behalf of the World Stroke Organization. Int J Stroke. 2023;18(5):499-531.\u00a0https:\/\/doi.org\/10.1177\/17474930231156753<\/p>\n<p>4.Bathla G, Ajmera P, Mehta PM, et al. Advances in acute ischemic stroke treatment: current status and future directions. AJNR Am J Neuroradiol. 2023;44(7):750-8.\u00a0https:\/\/doi.org\/10.3174\/ajnr.A7872<\/p>\n<p>5.Berge, E.; Whiteley, W.; Audebert, H.; et al. European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke. Eur. Stroke J. 2021, 6, I-LXII.\u00a0https:\/\/doi.org\/10.1177\/2396987321989865<\/p>\n<p>6.Turc, G.; Bhogal, P.; Fischer, U.; et al. European Stroke Organisation (ESO)-European Society for Minimally Invasive Neurological Therapy (ESMINT) Guidelines on Mechanical Thrombectomy in Acute Ischaemic Stroke. Eur. Stroke J. 2019, 4, 6-12. https:\/\/doi.org\/10.1177\/2396987319832140<\/p>\n<p>7.Dinsmore JE, Tan A. Anaesthesia for mechanical thrombectomy: a narrative review. Anaesthesia. 2022;77 (Suppl 1):59-68.\u00a0https:\/\/doi.org\/10.1111\/anae.15586<\/p>\n<p>8.Heran M, Lindsay P, Gubitz G, et al. 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Endovascular thrombectomy after anterior circulation large vessel ischemic stroke: an updated meta-analysis. Syst Rev. 2024;13(1):255.\u00a0https:\/\/doi.org\/10.1186\/s13643-024-02670-6<\/p>\n<p>16.Morsi RZ, Elfil M, Ghaith HS, et al. Endovascular thrombectomy for large ischemic strokes: An updated living systematic review and meta-analysis of randomized clinical trials. J Neurol Sci. 2024;460:123003.\u00a0https:\/\/doi.org\/10.1016\/j.jns.2024.123003<\/p>\n<p>17.Uchida K, Rinkel LA, Ospel JM, Diprose WK, Goyal M. A systematic review of randomized controlled trials of endovascular therapy for stroke on mortality and disability. J Neurol Sci. 2024;460:122991.\u00a0https:\/\/doi.org\/10.1016\/j.jns.2024.122991<\/p>\n<p>18.Hukamdad M, Biller J, Testai FD, Trifan G. Endovascular thrombectomy for large core volume acute ischemic stroke. Updated systematic review and meta-analysis. J Stroke Cerebrovasc Dis. 2025;34(1):108135.\u00a0https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2024.108135<\/p>\n<p>19.Sarraj A, Yoshimura S, Thomalla G, et al. Mechanical thrombectomy for large ischemic stroke: a critical appraisal of evidence from 6 randomized controlled trials. Stroke. 2025;56(7):1917-27.\u00a0https:\/\/doi.org\/10.1161\/STROKEAHA.125.050402<\/p>\n<p>20.Longoni M, Giacomozzi S, Pantoni L, Vidale S. Endovascular treatment in ischemic strokes with large infarct core: an updated systematic review and meta-analysis of randomized controlled trials. Neurol Sci. 2025;46(2):801-6.\u00a0https:\/\/doi.org\/10.1007\/s10072-024-07781-5<\/p>\n<p>21.Gharaibeh K, Aladamat N, Mierzwa AT, et al. Blood pressure after successful endovascular therapy: a systematic review and meta-analysis of randomized controlled trials. Ann Neurol. 2024;95(5):858-65.\u00a0https:\/\/doi.org\/10.1002\/ana.26907<\/p>\n<p>22.da Silva Neto EP, Ferreira LF, de Cardozo Hernandez ALC, et al. 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Effects of robot-assisted gait training on motor performance of lower limb in poststroke survivors: a systematic review with meta-analysis. Eur Rev Med Pharmacol Sci. 2024;28(3):879-98.\u00a031.Mansour S, Ang KK, Nair KPS, et al. Efficacy of brain-computer interface and the impact of its design characteristics on poststroke upper-limb rehabilitation. Clin EEG Neurosci. 2022;53(1):79-90. https:\/\/doi.org\/10.1177\/15500594211009065<\/p>\n<p>32.Saikaley M, McIntyre A, Pauli G, Teasell R. A systematic review of randomized controlled trial characteristics for interventions to improve upper extremity motor recovery post stroke. Top Stroke Rehabil. 2023;30(4):323-32. https:\/\/doi.org\/10.1080\/10749357.2022.2035578<\/p>\n<p>33.Yang FA, Lin CL, Cho SY, et al. Short- and long-term effects of repetitive transcranial magnetic stimulation on poststroke visuospatial neglect: a systematic review and meta-analysis of randomized controlled trials. Am J Phys Med Rehabil. 2023;102(6):522-32.\u00a0https:\/\/doi.org\/10.1097\/PHM.0000000000002151<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prof. O.E. Dubenko 1, prof. O.A. Oparin 2, assoc. prof. L.A. Sysun 1\u00a0 1 Kharkiv National Medical University, 2 Ukrainian Humanitarian Institute The article presents modern views on the etiopathogenesis of ischemic stroke, data on research and methods of its treatment, and discusses the issue of endovascular and drug thrombolysis. Preventive measures to reduce the&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,137],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":false,"content":false,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4718"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=4718"}],"version-history":[{"count":5,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4718\/revisions"}],"predecessor-version":[{"id":4800,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4718\/revisions\/4800"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=4718"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=4718"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=4718"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}