{"id":4329,"date":"2025-05-01T15:52:53","date_gmt":"2025-05-01T13:52:53","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=4329"},"modified":"2025-06-06T17:54:38","modified_gmt":"2025-06-06T15:54:38","slug":"%d0%be%d1%81%d1%82%d0%b5%d0%be%d0%b0%d1%80%d1%82%d1%80%d0%b8%d1%82-%d0%b4%d0%b5%d1%84%d1%96%d0%bd%d1%96%d1%86%d1%96%d1%8f-%d1%80%d0%be%d0%b7%d0%bf%d0%be%d0%b2%d1%81%d1%8e%d0%b4%d0%b6%d0%b5%d0%bd","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/4329","title":{"rendered":"Osteoarthritis: definition, prevalence and diagnostic strategy. The role of bone-cartilage markers in joint condition assessment"},"content":{"rendered":"<p><strong>Prof. L. Pasieshvili, assist. A. Litvinova, assist. A. Golozubova<\/strong><\/p>\n<p><strong>Kharkiv National Medical University<\/strong><\/p>\n<p>The document contains current data on the pathogenesis of osteoarthritis. The disease is very common, and diagnosis by interrogation and X-ray examination were discussed. The results of studies on the role of apelin in adipokines and osteoprotegerin in pathogenesis of the disease are presented.<\/p>\n<p><strong>Key words<\/strong>: osteoarthritis, pathogenesis, diagnosis, apelin, osteoprotegerin.<\/p>\n<p data-sourcepos=\"7:1-11:80\"><strong>https:\/\/doi.org\/10.15407\/internalmed2025.01.043<\/strong><\/p>\n<p><a href=\"http:\/\/www.internalmed-journal.in.ua\/wp-content\/uploads\/2025\/06\/\u0421\u041c_1_2025_08_05_2025-43-49.pdf\"><strong>Download.PDF (ukr)<\/strong><\/a><\/p>\n<p><strong>Cite:<\/strong><\/p>\n<p>\u041f\u0430\u0441\u0456\u0454\u0448\u0432\u0456\u043b\u0456 \u041b.\u041c., \u041b\u0456\u0442\u0432\u0456\u043d\u043e\u0432\u0430 \u0410.\u041c., \u0413\u043e\u043b\u043e\u0437\u0443\u0431\u043e\u0432\u0430 \u041e.\u0412. \u041e\u0441\u0442\u0435\u043e\u0430\u0440\u0442\u0440\u0438\u0442: \u0434\u0435\u0444\u0456\u043d\u0456\u0446\u0456\u044f, \u0440\u043e\u0437\u043f\u043e\u0432\u0441\u044e\u0434\u0436\u0435\u043d\u0456\u0441\u0442\u044c \u0442\u0430 \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u043d\u0430 \u0441\u0442\u0440\u0430\u0442\u0435\u0433\u0456\u044f. \u0420\u043e\u043b\u044c \u043c\u0430\u0440\u043a\u0435\u0440\u0456\u0432 \u043a\u0456\u0441\u0442\u043a\u043e\u0432\u043e-\u0445\u0440\u044f\u0449\u043e\u0432\u043e\u0457 \u0442\u043a\u0430\u043d\u0438\u043d\u0438 \u0432 \u043e\u0446\u0456\u043d\u0446\u0456 \u0441\u0442\u0430\u043d\u0443 \u0441\u0443\u0433\u043b\u043e\u0431\u0456\u0432 \/\u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. \u2013 2025. \u2013 \u2116 1. \u2013 \u0421. 43-49. doi.org\/10.15407\/internalmed2025.01.043<\/p>\n<p>Pasieshvili L, Litvinova A, Golozubova \u041e. Osteoarthritis: definition, prevalence and diagnostic strategy. The role of bone-cartilage markers in joint condition assessment. Shidnoevropejskij Zurnal Vnutrisnoi Ta Simejnoi Medicini. 2025(1):43-49. doi.org\/10.15407\/internalmed2025.01.043<\/p>\n<p><strong>References:<\/strong><\/p>\n<ol>\n<li>Mehana, E. S. E., Khafaga, A. F., &amp; El-Blehi, S. S. (2019). The role of matrix metalloproteinases in osteoarthritis pathogenesis: An updated review. Life sciences, 234, 116786. https:\/\/doi.org\/10.1016\/j.lfs.2019.116786<\/li>\n<li>Sun, K., Luo, J., Guo, J., Yao, X., Jing, X., &amp; Guo, F. (2020). The PI3K\/AKT\/mTOR signaling pathway in osteoarthritis: a narrative review. Osteoarthritis and cartilage, 28(4), 400-409. https:\/\/doi.org\/10.1016\/j.joca.2020.02.027<\/li>\n<li>Roemer, F. W., Demehri, S., Omoumi, P., Link, T. M., Kijowski, R., Saarakkala, S., &amp; Guermazi, A. (2020). State of the art: Imaging of osteoarthritis-Revisited 2020. 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(2015). \u041f\u0440\u043e\u0442\u0435\u0438\u043d\u044b \u0432\u043d\u0435\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u043e\u0433\u043e \u043c\u0430\u0442\u0440\u0438\u043a\u0441\u0430 \u043a\u0430\u043a \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u044b \u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0433\u043e \u0440\u0435\u043c\u043e\u0434\u0435\u043b\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0438 \u043a\u0430\u0440\u0434\u0438\u043e\u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0445 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0438\u0441\u0445\u043e\u0434\u043e\u0432 (\u043e\u0431\u0437\u043e\u0440 \u043b\u0438\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u044b). \u0423\u043a\u0440\u0430\u0457\u043d\u0441\u044c\u043a\u0438\u0439 \u043c\u0435\u0434\u0438\u0447\u043d\u0438\u0439 \u0447\u0430\u0441\u043e\u043f\u0438\u0441, (6), 58-64.<\/li>\n<li>Ostrowska, Z., Ziora, K., O\u015bwi\u0119cimska, J., \u015awi\u0119tochowska, E., Szapska, B., Wo\u0142kowska-Pokrywa, K., &amp; Dyduch, A. 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The disease is very common, and diagnosis by interrogation and X-ray examination were discussed. The results of studies on the role of apelin in adipokines and osteoprotegerin in pathogenesis of the disease&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,43,133],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":false,"content":false,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4329"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=4329"}],"version-history":[{"count":6,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4329\/revisions"}],"predecessor-version":[{"id":4497,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/4329\/revisions\/4497"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=4329"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=4329"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=4329"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}