{"id":3586,"date":"2023-06-15T22:49:36","date_gmt":"2023-06-15T20:49:36","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=3586"},"modified":"2023-08-11T14:19:34","modified_gmt":"2023-08-11T12:19:34","slug":"%d0%be%d1%86%d1%96%d0%bd%d0%ba%d0%b0-%d0%b5%d1%84%d0%b5%d0%ba%d1%82%d0%b8%d0%b2%d0%bd%d0%be%d1%81%d1%82%d1%96-%d0%ba%d0%be%d0%bc%d0%b1%d1%96%d0%bd%d0%be%d0%b2%d0%b0%d0%bd%d0%be%d0%b3%d0%be-%d0%bb","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/3586","title":{"rendered":"Evaluation of the effectiveness of combined treatment in patients with comorbid COPD and GERD"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Asp. Semenova N.V., assoc. prof. Oparina T.M.<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Kharkiv National Medical University <\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>\u0422<\/strong><strong>herapy department \u21162 <\/strong><\/p>\n<p style=\"text-align: justify;\">Gastroesophageal reflux disease (GERD) is often comorbid with chronic obstructive pulmonary disease (COPD). Such coexisting pathology in the initial stage, which is present in young patients, but poorly studied. The purpose of our study is to study the effectiveness of the use of combined therapy using the example of the addition of Dalargin in patients with GERD and COPD. We took into the study 60 young people with a confirmed combined course of GERD and COPD and divided them into two equal groups. The first group received an addition to the basic treatment Dalargin, and the second group \u2014 placebo. The effectiveness of the treatment was evaluated by comparing the indicators of ERF, gastric juice pH, norepinephrine level, and depressive and anxiety disorders. It was established that combined treatment in patients with GERD with concomitant COPD reliably improves all the studied indicators.<\/p>\n<p style=\"text-align: justify;\"><strong>Key words:<\/strong> gastroesophageal reflux disease, chronic obstructive pulmonary disease, combined therapy<\/p>\n<p style=\"text-align: justify;\"><a href=\"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/3586\"><strong>\u00a0<\/strong><strong>https:\/\/doi.org\/10.15407\/internalmed2023.02.080<\/strong><\/a><\/p>\n<p style=\"text-align: justify;\"><a href=\"http:\/\/www.internalmed-journal.in.ua\/wp-content\/uploads\/2023\/06\/\u0416\u0443\u0440\u043d\u0430\u043b_2_2023_19_06-80-83.pdf\"><strong>Download.PDF (ukr)<\/strong><\/a><\/p>\n<p style=\"text-align: justify;\"><strong>Cite:<\/strong><\/p>\n<ol>\n<li>\u0421\u0435\u043c\u0435\u043d\u043e\u0432\u0430, \u041d.\u0412. \u041e\u0446\u0456\u043d\u043a\u0430 \u0435\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0456 \u043a\u043e\u043c\u0431\u0456\u043d\u043e\u0432\u0430\u043d\u043e\u0433\u043e \u043b\u0456\u043a\u0443\u0432\u0430\u043d\u043d\u044f \u0443 \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0456\u0432 \u0437 \u043a\u043e\u043c\u043e\u0440\u0431\u0456\u0434\u043d\u0438\u043c \u043f\u0435\u0440\u0435\u0431\u0456\u0433\u043e\u043c \u0425\u041e\u0417\u041b \u0442\u0430 \u0413\u0415\u0420\u0425 \/ \u041d.\u0412. \u0421\u0435\u043c\u0435\u043d\u043e\u0432\u0430, \u041e\u043f\u0430\u0440\u0456\u043d\u0430 \u0422.\u041c. \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. &#8211; 2023. &#8211; \u2116 2. &#8211; \u0421. 80-83. http:\/\/doi.org\/10.15407\/internalmed2023.02.080<\/li>\n<li>Semenova NV, Oparina TM. [Evaluation of the effectiveness of combined treatment in patients with comorbid COPD and GERD]. Shidnoevr. z. vnutr. simejnoi med. 2023;2:80-83. Ukrainian. http:\/\/doi.org\/10.15407\/internalmed2023.02.080<\/li>\n<\/ol>\n<p style=\"text-align: justify;\"><strong>References:<\/strong><\/p>\n<ol>\n<li>Moll, Matthew. Machine learning and prediction of allcause mortality in COPD. Chest. 2020;158.3:952-964.<\/li>\n<li>Halpin D, Celli B, Criner G, Frith P, L\u00f3pez Varela M, Salvi S, Vogelmeier C, Chen R, Mortimer K, Montes de Oca M, Aisanov Z, Obaseki D, Decker R, Agusti A. It is time for the world to take COPD seriously: a statement from the GOLD board of directors. European Respiratory Journal. 2019;54(1):1900914. http:\/\/dx.doi.org\/10.1183\/13993003.00914-2019<\/li>\n<li>Oparin A, Beziazychna N. Implementation mechanisms of psychosomatic disorders in gastroesophageal reflux disease with concomitant chronic obstructive pulmonary disease. Medica Jadertina 2016; 46(3-4): 125-126. Hr\u010dak ID: 167277. ISSN 1848-817X.<\/li>\n<li>Zou M, Zhang W, Xu Y, Zhu Y. Relationship Between COPD and GERD: A Bibliometrics Analysis. International Journal of Chronic Obstructive Pulmonary Disease. 2022;17:3045-3059. http:\/\/dx.doi.org\/10.2147\/copd.s391878<\/li>\n<li>Hafiz M, Yunus F, Suryamin M, Alatas M, Wibowo A. Prevalence and Risk Factors of GERD among Stable COPD Patients. Jurnal Respirasi. 2023;9(1):1-6. http:\/\/dx.doi.org\/10.20473\/jr.v9-i.1.2023.1-6<\/li>\n<li>Osyodlo G, Bychkova S. Bronchopulmonary \u00abMasks\u00bb of Gastroesophageal reflux disease. The Pharma Innovation Journal. 2019; 8(6): 638-641.<\/li>\n<li>Khamitov R, Zinnatullina A. Study of gastroesophageal reflux disease in frequent exacerbations of chronic obstructive pulmonary disease. Monitoring airway disease. 2021;:. http:\/\/dx.doi.org\/10.1183\/13993003.congress-2021.pa2225<\/li>\n<li>Oparin A, Oparin A, Kudriavtsev A. 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Effects of gastroesophageal reflux disease treatment with proton pump inhibitors on the risk of acute exacerbation and pneumonia in patients with COPD. Respiratory Research. 2023;24(1):. http:\/\/dx.doi.org\/10.1186\/s12931-023-02345-1<\/li>\n<li>Martynov Yu, Kukovska I. Analiz mozhlyvosti vykorystannia Dalarhinu v kompleksnomu likuvanni Sovid-19. \u039b\u03ccho\u03c3. Onlain; 2020. 9 \u0440. DOI 10.36074\/2663-4139.11.01.<\/li>\n<li>Shcheniavsky I. Anti-Apoptotic Effect of Synthetic Leu-Enkephalin Dalargin on Rat Leukocytes in Cold Stress Model in Vivo. Problems of Cryobiology and Cryomedicine. 2021;31(1):3-13. http:\/\/dx.doi.org\/10.15407\/cryo31.01.003<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Asp. Semenova N.V., assoc. prof. Oparina T.M. Kharkiv National Medical University \u0422herapy department \u21162 Gastroesophageal reflux disease (GERD) is often comorbid with chronic obstructive pulmonary disease (COPD). Such coexisting pathology in the initial stage, which is present in young patients, but poorly studied. The purpose of our study is to study the effectiveness of the&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,8,34,108,100],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":false,"content":false,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/3586"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=3586"}],"version-history":[{"count":6,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/3586\/revisions"}],"predecessor-version":[{"id":3746,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/3586\/revisions\/3746"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=3586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=3586"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=3586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}