{"id":2617,"date":"2021-08-04T13:05:31","date_gmt":"2021-08-04T11:05:31","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=2617"},"modified":"2021-11-16T14:57:51","modified_gmt":"2021-11-16T12:57:51","slug":"%d1%80%d0%be%d0%bb%d1%8c-%d0%b3%d0%be%d1%80%d0%bc%d0%be%d0%bd%d1%96%d0%b2-%d0%b6%d0%b8%d1%80%d0%be%d0%b2%d0%be%d1%97-%d1%82%d0%ba%d0%b0%d0%bd%d0%b8%d0%bd%d0%b8-%d1%83-%d1%84%d0%be%d1%80%d0%bc%d1%83","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/2617","title":{"rendered":"The role of adipose tissue hormones in the formation and course of gastroesophageal reflux disease in combination with obesity."},"content":{"rendered":"

Prof. O.A. Oparin, O.M. Mal<\/strong>\u0456<\/strong>ar, PHD T.N. Oparina, E. J. Abakumova <\/strong><\/p>\n

Kharkiv Medical Academy of Postgraduate Education <\/strong><\/p>\n

Objective: To investigate the level of leptin in patients with gastroesophageal reflux disease with concomitant obesity and evaluate its effect on the course of the disease. Materials and results. The study involved 50 patients. The first group included patients with GERD with concomitant obesity, the second group \u2014 patients with GERD without concomitant pathology. A survey was conducted using the GERDQ questionnaire, which showed that patients with concomitant obesity were more likely to have symptoms of the disease. Leptin levels were determined by enzyme-linked immunosorbent assay. \u0406n subjects of group 1, the concentration of leptin will be significantly higher than in patients of group 2. An endoscopic study was performed, the results of which were compared with the concentration of leptin. There is a direct correlation between body mass index, the degree of esophageal damage and leptin levels.<\/p>\n

Key Words<\/strong>: gastroesophageal reflux disease, GERD, obesity, leptin, adipokines.<\/p>\n

https:\/\/dx.doi.org\/10.15407\/internalmed2021.02.096<\/strong><\/a><\/p>\n

Download.PDF (ukr)<\/strong><\/p>\n

Cite:<\/strong><\/p>\n

    \n
  1. \u041e\u043f\u0430\u0440\u0456\u043d, \u041e.\u0410. \u0420\u043e\u043b\u044c \u0433\u043e\u0440\u043c\u043e\u043d\u0456\u0432 \u0436\u0438\u0440\u043e\u0432\u043e\u0457 \u0442\u043a\u0430\u043d\u0438\u043d\u0438 \u0443 \u0444\u043e\u0440\u043c\u0443\u0432\u0430\u043d\u043d\u0456 \u0442\u0430 \u043f\u0435\u0440\u0435\u0431\u0456\u0433\u0443 \u0433\u0430\u0441\u0442\u0440\u043e\u0435\u0437\u043e\u0444\u0430\u0433\u0435\u0430\u043b\u044c\u043d\u043e\u0457 \u0440\u0435\u0444\u043b\u044e\u043a\u0441\u043d\u043e\u0457 \u0445\u0432\u043e\u0440\u043e\u0431\u0438 \u0443 \u043f\u043e\u0454\u0434\u043d\u0430\u043d\u043d\u0456 \u0437 \u043e\u0436\u0438\u0440\u0456\u043d\u043d\u044f\u043c \/ \u041e.\u0410. \u041e\u043f\u0430\u0440\u0456\u043d, \u041e.\u041c. \u041c\u0430\u043b\u044f\u0440, \u0422.\u041d. \u041e\u043f\u0430\u0440\u0456\u043d\u0430, \u041e. \u042f. \u0410\u0431\u0430\u043a\u0443\u043c\u043e\u0432\u0430 \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. – 2021. – \u2116 2. – \u0421. 96-98. doi: 15407\/internalmed2021.02.096<\/li>\n
  2. Oparin OA, Mal\u0456ar OM, Oparina TN, Abakumova EJ. Rol hormoniv zhyrovoi tkanyny u formuvanni ta perebihu hastroezofahealnoi refliuksnoi khvoroby u poiednanni z ozhyrinniam. [The role of adipose tissue hormones in the formation and course of gastroesophageal reflux disease in combination with obesity]. Shidnoevr. z. vnutr. simejnoi med. 2021;2:96-98. Ukrainian. doi: 10.15407\/internalmed2021.02.096<\/li>\n<\/ol>\n

    References:<\/strong><\/p>\n

      \n
    1. Zvenigorodskaja LA, Bondarenko EJu, Churikova AA. Osobennosti terapii gastrojezofageal’noj refljuksnoj bolezni u bol’nyh s abdominal’nym ozhireniem. Gastrojenterologija: Prilozhenie k zhurnalu Consilium Medicum. 2012; 1:11\u201414. Russian<\/li>\n
    2. Wu Y, Tseng P, Lee Y, Wang S, Chiu H, Tu C, Wang H, Lin J, Wu M, Yang W. Association of Esophageal Inflammation, Obesity and Gastroesophageal Reflux Disease: From FDG PET\/CT Perspective. PLoS ONE. 2014;9(3):12-127. http:\/\/dx.doi.org\/10.1371\/journal.pone.0092001<\/li>\n
    3. Howard J, Pidgeon G, Reynolds J. Leptin and gastro-intestinal malignancies. Obesity Reviews. 2010;11(12):863-874. http:\/\/dx.doi.org\/10.1111\/j.1467-789x.2010.00718.x<\/li>\n
    4. Singla P. Metabolic effects of obesity: A review. World Journal of Diabetes. 2010;1(3):76. http:\/\/dx.doi.org\/10.4239\/wjd.v1.i3.76<\/li>\n
    5. Pasieshvili LM, Zheleznjakova NM, Pasieshvili TM. Problema ozhirenija v obshhevrachebnoj praktike. Vostochnoevropejskij zhurnal vnutrennej i semejnoj mediciny. 2014;1:37\u201443. Russian<\/li>\n
    6. Fadieienko H.D., Kushnir I.E., Chernova V.M., Bondar T.M. Kryterii prohnozuvannia perebihu ta rozvytku uskladnen hastroezofahealnoi refliuksnoi khvoroby u khvorykh z riznym trofolohichnym statusom \/\/ Suchasna hastroenterolohiia. \u2014 2014. \u2014 # 5 (79). \u2014 S. 110\u2014112. Ukrainian<\/li>\n
    7. Oparin A, Lavrova N, Kornienko D. Features of Motility and Secretory Disorders in Different Forms of Gastroesophageal Reflux Disease. Bulletin of problems biology and medicine. 2013;3:131-133. Russian.<\/li>\n
    8. Oparin A, Vnukova A. The Role of Endothelial Dysfunction in the Mechanism of Gastroesophageal Reflux Disease Development in Patients with Ischemic Heart Disease. Acta clinica Croatica. 2017; 56(4):635-639. Russian. https:\/\/doi. org\/10.20471\/acc.2017.56.04.08.<\/li>\n
    9. Metlakunta A, Sahu M, Yasukawa H, Dhillon S, Belsham D, Yoshimura A, Sahu A. Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2011;300(5):R1185-R1193. http:\/\/dx.doi.org\/10.1152\/ajpregu.00794.2010<\/li>\n
    10. Chandar A, Iyer P. Role of Obesity in the Pathogenesis and Progression of Barrett\u2019s Esophagus. Gastroenterology Clinics of North America. 2015;44(2):249-264. http:\/\/dx.doi.org\/10.1016\/j.gtc.2015.03.001<\/li>\n
    11. Wu Y, Tseng P, Lee Y, Wang S, Chiu H, Tu C, Wang H, Lin J, Wu M, Yang W. Association of Esophageal Inflammation, Obesity and Gastroesophageal Reflux Disease: From FDG PET\/CT Perspective. PLoS ONE. 2014;9(3):e92001. http:\/\/dx.doi.org\/10.1371\/journal.pone.0092001<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      Prof. O.A. Oparin, O.M. Mal\u0456ar, PHD T.N. Oparina, E. J. Abakumova Kharkiv Medical Academy of Postgraduate Education Objective: To investigate the level of leptin in patients with gastroesophageal reflux disease with concomitant obesity and evaluate its effect on the course of the disease. Materials and results. The study involved 50 patients. The first group included…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,13,62,56],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":true,"content":true,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/2617"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=2617"}],"version-history":[{"count":3,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/2617\/revisions"}],"predecessor-version":[{"id":2945,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/2617\/revisions\/2945"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=2617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=2617"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=2617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}