{"id":2330,"date":"2021-03-11T15:06:11","date_gmt":"2021-03-11T13:06:11","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=2330"},"modified":"2022-07-27T23:22:34","modified_gmt":"2022-07-27T21:22:34","slug":"%d0%b0%d0%bd%d1%82%d0%b8%d0%be%d0%ba%d1%81%d0%b8%d0%b4%d0%b0%d0%bd%d1%82%d0%bd%d0%b0-%d1%81%d0%b8%d1%81%d1%82%d0%b5%d0%bc%d0%b0-%d0%b2-%d0%bd%d0%be%d1%80%d0%bc%d1%96-%d1%82%d0%b0-%d0%bf%d1%80%d0%b8","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/2330","title":{"rendered":"Antioxidant system: norm and pathology"},"content":{"rendered":"<p><strong>Prof. L.M. Pasiyeshvili, prof. N.M. Zhelezniakova, as. prof. T.M. Pasiieshvili<\/strong><\/p>\n<p><strong>Kharkiv National Medical University<\/strong><\/p>\n<p>The atricle presents modern data on the composition and role of the antioxidant system in the human body.The stages and components of the system (enzymatic and non-enzymatic) are considered, classifications are given. Its participation in the pathogenesis of diseases and the progression of diseases has been proven.<\/p>\n<p><strong>Key Words<\/strong>: antioxidant system, composition, classification, role in the body.<\/p>\n<p><a href=\"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/2330\"><strong>https<\/strong><strong>:\/\/<\/strong><strong>dx<\/strong><strong>.<\/strong><strong>doi<\/strong><strong>.<\/strong><strong>org<\/strong><strong>\/10.15407\/internalmed2021.01.040<\/strong><\/a><\/p>\n<p><a href=\"http:\/\/www.internalmed-journal.in.ua\/wp-content\/uploads\/2021\/04\/\u0416\u0443\u0440\u043d\u0430\u043b_1_2021_40-46.pdf\" target=\"_blank\" rel=\"noopener\"><strong>Download<\/strong><strong>.<\/strong><strong>PDF (rus)<\/strong><\/a><\/p>\n<p><strong>For citing:<\/strong><\/p>\n<p>1. \u041f\u0430\u0441\u0438\u0435\u0448\u0432\u0438\u043b\u0438, \u041b.\u041c., \u0416\u0435\u043b\u0435\u0437\u043d\u044f\u043a\u043e\u0432\u0430, \u041d.\u041c., \u041f\u0430\u0441\u0438\u0435\u0448\u0432\u0438\u043b\u0438, \u0422.\u041c. \u0410\u043d\u0442\u0438\u043e\u043a\u0441\u0438\u0434\u0430\u043d\u0442\u043d\u0430\u044f \u0441\u0438\u0441\u0442\u0435\u043c\u0430 \u0432 \u043d\u043e\u0440\u043c\u0435 \u0438 \u043f\u0440\u0438 \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0438 \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. &#8211; 2021. &#8211; \u21161. \u2013 \u0421. 40-46. doi: 10.15407\/internalmed2021.01.040<\/p>\n<p>2. Pasiyeshvili LM, Zhelezniakova NM, Pasiyeshvili TM. [Antioxidant system: norm and pathology]. Shidnoevr. z. vnutr. simejnoi med. 2021;1:40-46. Russian. doi: 10.15407\/internalmed2021.01.040<\/p>\n<p><strong>References:<\/strong><\/p>\n<p>1. Foyer C, Noctor G. Redox Homeostasis and Antioxidant Signaling: A Metabolic Interface between Stress Perception and Physiological Responses. The Plant Cell. 2005;17(7):1866-1875. http:\/\/dx.doi.org\/10.1105\/tpc.105.033589<br \/>\nhttps:\/\/doi.org\/10.1105\/tpc.105.033589<\/p>\n<p>2. Elmore S. Apoptosis: A Review of Programmed Cell Death. Toxicologic Pathology. 2007;35(4):495-516. http:\/\/dx.doi.org\/10.1080\/01926230701320337<br \/>\nhttps:\/\/doi.org\/10.1080\/01926230701320337<\/p>\n<p>3. Tan B, Norhaizan M, Liew W, Sulaiman Rahman H. Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. Frontiers in Pharmacology. 2018;9:. http:\/\/dx.doi.org\/10.3389\/fphar.2018.01162<br \/>\nhttps:\/\/doi.org\/10.3389\/fphar.2018.01162<\/p>\n<p>4. Dasgupta A, Klein K. Oxidative Stress Caused by Cigarette Smoking, Alcohol Abuse, and Drug Abuse. Antioxidants in Food, Vitamins and Supplements. 2014;:59-75. http:\/\/dx.doi.org\/10.1016\/b978-0-12-405872-9.00004-5<br \/>\nhttps:\/\/doi.org\/10.1016\/B978-0-12-405872-9.00004-5<\/p>\n<p>5. Sun M, Jin H, Sun X, Huang S, Zhang F, Guo Z, Yang Y. Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy. Oxidative Medicine and Cellular Longevity. 2018;2018:1-17. http:\/\/dx.doi.org\/10.1155\/2018\/3804979<br \/>\nhttps:\/\/doi.org\/10.1155\/2018\/3804979<\/p>\n<p>6. Phaniendra A, Jestadi D, Periyasamy L. Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases. 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Bulletin of Experimental Biology and Medicine. 2013;154(5):597-601. http:\/\/dx.doi.org\/10.1007\/s10517-013-2008-5<br \/>\nhttps:\/\/doi.org\/10.1007\/s10517-013-2008-5<\/p>\n<p>10. Li B, Pratt D. Methods for determining the efficacy of radical-trapping antioxidants. Free Radical Biology and Medicine. 2015;82:187-202. http:\/\/dx.doi.org\/10.1016\/j.freeradbiomed.2015.01.020<br \/>\nhttps:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.01.020<\/p>\n<p>11. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews. 2010;4(8):118. http:\/\/dx.doi.org\/10.4103\/0973-7847.70902<br \/>\nhttps:\/\/doi.org\/10.4103\/0973-7847.70902<\/p>\n<p>12. Weydert C, Cullen J. Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue. Nature Protocols. 2009;5(1):51-66. http:\/\/dx.doi.org\/10.1038\/nprot.2009.197<br \/>\nhttps:\/\/doi.org\/10.1038\/nprot.2009.197<\/p>\n<p>13. Dubinina EE. Produkty metabolizma kisloroda v funkcional&#8217;noj aktivnosti kletok. SPb.: Izd-vo Med. Pressa; 2006. 397 \u0440. Russian<\/p>\n<p>14. Mahanova RS. K voprosu izuchenija perekisnogo okislenija lipidov. Izvestija Orenburgskogo gosudarstvennogo agrarnogo universiteta. 2011;1(29-1):231-234. Russian<\/p>\n<p>15. Gudkov SV, Bruskov VI, Kulikov AV. Bioantioksidanty (chast&#8217; 1). Al&#8217;manah klinicheskoj mediciny.2014;1:61-65. Russian . doi.: org\/10.18786\/2072-0505-2014-31-61-65<br \/>\nhttps:\/\/doi.org\/10.18786\/2072-0505-2014-31-61-65<\/p>\n<p>16. Fels J, Callies C, Kusche-Vihrog K, Oberleithner H. Nitric oxide release follows endothelial nanomechanics and not vice versa. Pfl\u00fcgers Archiv &#8211; European Journal of Physiology. 2010;460(5):915-923. http:\/\/dx.doi.org\/10.1007\/s00424-010-0871-8<br \/>\nhttps:\/\/doi.org\/10.1007\/s00424-010-0871-8<\/p>\n<p>17. Rahal A, Kumar A, Singh V, Yadav B, Tiwari R, Chakraborty S, Dhama K. Oxidative Stress, Prooxidants, and Antioxidants: The Interplay. BioMed Research International. 2014;2014:1-19. http:\/\/dx.doi.org\/10.1155\/2014\/761264<br \/>\nhttps:\/\/doi.org\/10.1155\/2014\/761264<\/p>\n<p>18. Phaniendra A, Jestadi D, Periyasamy L. Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases. Indian Journal of Clinical Biochemistry. 2014;30(1):11-26. http:\/\/dx.doi.org\/10.1007\/s12291-014-0446-0<br \/>\nhttps:\/\/doi.org\/10.1007\/s12291-014-0446-0<\/p>\n<p>19. Churnosov MI, Poljakova IS, Pahomov S\u0420, Orlova VS. Molekuljarnye i geneticheskie mehanizmy biotransformacii ksenobiotikov. Nauchnye vedomosti belgorodskogo gosudarstvennogo universiteta. Serija: medicina. Farmacija. 2011;16(111):223- 228. Russian<\/p>\n<p>20. Gaucher C, Boudier A, Bonetti J, Clarot I, Leroy P, Parent M. Glutathione: Antioxidant Properties Dedicated to Nanotechnologies. Antioxidants. 2018;7(5):62. http:\/\/dx.doi.org\/10.3390\/antiox7050062<br \/>\nhttps:\/\/doi.org\/10.3390\/antiox7050062<\/p>\n<p>21. Pokrovskij VI, Vinogradov NA. Oksid azota, ego fiziologicheskie i patofiziologicheskie svojstva. Ter. arhiv. 2005;1:82-87. Russian<\/p>\n<p>22. Pizzorno J. Glutathione!. Integr Med (Encinitas). 2014;13(1):8-12.<\/p>\n<p>23. Kulinskij VI. Sistema glutationa. I. Sintez, transport, glutationtransferazy, glutationperoksidazy. Biomedicinskaja himija. 2009;55(3):255-277. Russian<\/p>\n<p>24. Isheeva O. D. Klassifikacija sistemy antioksidantnoj zashhity kak osnova racional&#8217;noj organizacii jeksperimental&#8217;nogo issledovanija okislitel&#8217;nogo stressa u rastenij \/ O. D. Isheeva, E. V. Pradedova, R. K. Saljaev \/\/ Fiziologija rastenij. &#8211; 2011. &#8211; #58(2). &#8211; S.210-217. Russian<\/p>\n<p>25. Kurutas E. The importance of antioxidants which play the role in cellular response against oxidative\/nitrosative stress: current state. Nutrition Journal. 2015;15(1):. http:\/\/dx.doi.org\/10.1186\/s12937-016-0186-5<br \/>\nhttps:\/\/doi.org\/10.1186\/s12937-016-0186-5<\/p>\n<p>26. Kolupaev JuE, Karpec JuV. Aktivnye formy kisloroda, antioksidanty i ustojchivost&#8217; rastenij k dejstviju stressorov. Kiev: Logos; 2019. 277 \u0440. Russian<\/p>\n<p>27. Michiels C, Raes M, Toussaint O, Remacle J. Importance of SE-glutathione peroxidase, catalase, and CU\/ZN-SOD for cell survival against oxidative stress. Free Radical Biology and Medicine. 1994;17(3):235-248. http:\/\/dx.doi.org\/10.1016\/0891-5849(94)90079-5<br \/>\nhttps:\/\/doi.org\/10.1016\/0891-5849(94)90079-5<\/p>\n<p>28. Rogozhin VV. Peroksidaza kak komponent antioksidantnoj sistemy zhivyh organizmov. SPb.: GIORD; 2004. 240 \u0440. Russian<\/p>\n<p>29. Chesnokova NP, Ponukalina EV, Bizenkova MN. Obshhaja harakteristika istochnikov obrazovanija svobodnyh radikalov i antioksidantnyh sistem. Uspehi sovrem. estestvoznanija. 2006;7:37-41. Russian<\/p>\n<p>30. Zajcev VG, Ostrovskij OV, Zakrevskij VI. Svjaz&#8217; mezhdu himicheskim stroeniem i mishen&#8217;ju dejstvija kak osnova dejstvija klassifikacii antioksidantov prjamogo dejstvija. Jeksperim. klin. farmakol. 2003;66:66-70. Russian<\/p>\n<p>31. Polesskaja OG. Rastitel&#8217;naja kletka i aktivnye formy kisloroda. M.: Knizhnyj Dom Universitet; 2007. 140 \u0440. Russian<\/p>\n<p>32. Havinson VH, Barinov VA, Arutjunjan AV, Malinin VV. Svobodno-radikal&#8217;noe okislenie i starenie. SPb.: Nauka; 2003. 327 \u0440. Russian<\/p>\n<p>33. Lju BN, Efimov ML. Antioksidantnaja sistema kletki i kancerogenez. Uspehi sovrem. biol. 1976;82: 236-251. Russian<\/p>\n<p>34. Borisova GG. Metody ocenki antioksidantnogo statusatrastenij. Ekaterinburg: Izd-vo Ural un-ta; 2012. 72 \u0440. Russian<\/p>\n<p>35. Pajares M, Cuadrado A, Engedal N, Jirsova Z, Cahova M. The Role of Free Radicals in Autophagy Regulation: Implications for Ageing. Oxidative Medicine and Cellular Longevity. 2018;2018:1-19. http:\/\/dx.doi.org\/10.1155\/2018\/2450748<br \/>\nhttps:\/\/doi.org\/10.1155\/2018\/2450748<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prof. L.M. Pasiyeshvili, prof. N.M. Zhelezniakova, as. prof. T.M. Pasiieshvili Kharkiv National Medical University The atricle presents modern data on the composition and role of the antioxidant system in the human body.The stages and components of the system (enzymatic and non-enzymatic) are considered, classifications are given. 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