{"id":2313,"date":"2021-03-11T14:45:55","date_gmt":"2021-03-11T12:45:55","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=2313"},"modified":"2021-11-16T15:09:57","modified_gmt":"2021-11-16T13:09:57","slug":"%d1%83%d1%80%d0%b0%d0%b6%d0%b5%d0%bd%d0%bd%d1%8f-%d1%81%d0%b5%d1%80%d1%86%d0%b5%d0%b2%d0%be-%d1%81%d1%83%d0%b4%d0%b8%d0%bd%d0%bd%d0%be%d1%97-%d1%81%d0%b8%d1%81%d1%82%d0%b5%d0%bc%d0%b8-%d0%bf%d1%80","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/2313","title":{"rendered":"Damage to the cardiovascular system in COVID-19"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Prof. O.M. Korzh<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>Kharkiv Medical Academy of Postgraduate Education<\/strong><\/p>\n<p style=\"text-align: justify;\">COVID-19 affects not only the respiratory system, but also the cardiovascular system. The damage to the cardiovascular system in COVID-19 is multifactorial and several mechanisms are involved, including direct invasion, inflammation, thrombosis, autoantibody synthesis, and oxygen imbalance. The inflammation causes the release of cytokines, especially interleukin-6, and damage to cardiomyocytes. The overproduction of cytokines leads to an abnormal inflammatory response called a cytokine storm, which is believed to be the culprit in cardiovascular events in COVID-19 patients. Treatment of COVID-19 patients with cardiovascular complications is mostly supportive. The role of pharmacological blocking of the renin-angiotensin-aldosterone system in patients with cardiovascular disease and COVID-19 infection requires further research as the relationship appears to be very complex. To date, professional cardiological societies do not recommend canceling ACE inhibitors or agiotensin II receptor antagonists for patients taking these drugs for other indications. Special care should be taken about the potential cardiovascular side effects of the various therapies used to treat viral infections. When using them, daily monitoring of the QT interval on the ECG is proposed.<\/p>\n<p style=\"text-align: justify;\"><strong>Key Words: <\/strong>COVID-19, pandemic, myocardial injury, cardiovascular disease<\/p>\n<p style=\"text-align: justify;\"><a href=\"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/2313\"><strong>https<\/strong><strong>:\/\/<\/strong><strong>dx<\/strong><strong>.<\/strong><strong>doi<\/strong><strong>.<\/strong><strong>org<\/strong><strong>\/10.15407\/internalmed2021.01.010<\/strong><\/a><\/p>\n<p style=\"text-align: justify;\"><a href=\"http:\/\/www.internalmed-journal.in.ua\/wp-content\/uploads\/2021\/04\/\u0416\u0443\u0440\u043d\u0430\u043b_1_2021_10-16.pdf\" target=\"_blank\" rel=\"noopener\"><strong>Download<\/strong><strong>.<\/strong><strong>PDF (rus)<\/strong><\/a><\/p>\n<p style=\"text-align: justify;\"><strong>For citing:<\/strong><\/p>\n<p>1. \u041a\u043e\u0440\u0436, \u0410.\u041d. \u041f\u043e\u0440\u0430\u0436\u0435\u043d\u0438\u0435 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043f\u0440\u0438 COVID-19\/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. &#8211; 2021. &#8211; \u21161. \u2013 \u0421. 10-16. doi: 10.15407\/internalmed2021.01.010<\/p>\n<p>2. Korzh OM. [Damage to the cardiovascular system in COVID-19]. Shidnoevr. z. vnutr. simejnoi med. 2021;1:10-16. Russian. doi: 10.15407\/internalmed2021.01.010<\/p>\n<p style=\"text-align: justify;\"><strong>References:<\/strong><\/p>\n<p>1. Hendren N, Drazner M, Bozkurt B, Cooper L. Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome. Circulation. 2020;141(23):1903-1914. http:\/\/dx.doi.org\/10.1161\/circulationaha.120.047349<br \/>\n2. Driggin E, Madhavan M, Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai G, Brown T, Der Nigoghossian C, Zidar D, Haythe J, Brodie D, Beckman J, Kirtane A, Stone G, Krumholz H, Parikh S. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic. Journal of the American College of Cardiology. 2020;75(18):2352-2371. http:\/\/dx.doi.org\/10.1016\/j.jacc.2020.03.031<br \/>\n3. Geng Y, Wei Z, Qian H, Huang J, Lodato R, Castriotta R. 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Han Y, Zeng H, Jiang H, Yang Y, Yuan Z, Cheng X, Jing Z, Liu B, Chen J, Nie S, Zhu J, Li F, Ma C. CSC Expert Consensus on Principles of Clinical Management of Patients With Severe Emergent Cardiovascular Diseases During the COVID-19 Epidemic. Circulation. 2020;141(20):. http:\/\/dx.doi.org\/10.1161\/circulationaha.120.047011<br \/>\n28. Sanders J, Monogue M, Jodlowski T, Cutrell J. Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19). JAMA. 2020;:. http:\/\/dx.doi.org\/10.1001\/jama.2020.6019<br \/>\n29. ASE statement on protection of patients and echocardiography service providers during the 2019 novel coronavirus outbreak. Journal of The Indian Academy of Echocardiography &amp; Cardiovascular Imaging. 2020;4(1):137. http:\/\/dx.doi.org\/10.4103\/2543-1463.282193<br \/>\n30. Oren O, Kopecky S, Gluckman T. Coronavirus Disease 2019 (COVID-19): Epidemiology, Clinical Spectrum and Implications for the Cardiovascular Clinician. Available at: https:\/\/www.acc.org\/latest-in-cardiology\/ articles\/2020\/04\/06\/11\/08\/covid-19-epidemiology-clinicalspectrum-and-implications-for-the-cv-clinician [Accessed 10 April 2020].<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prof. O.M. Korzh Kharkiv Medical Academy of Postgraduate Education COVID-19 affects not only the respiratory system, but also the cardiovascular system. The damage to the cardiovascular system in COVID-19 is multifactorial and several mechanisms are involved, including direct invasion, inflammation, thrombosis, autoantibody synthesis, and oxygen imbalance. The inflammation causes the release of cytokines, especially interleukin-6,&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[48,9,54],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":true,"content":true,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/2313"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=2313"}],"version-history":[{"count":6,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/2313\/revisions"}],"predecessor-version":[{"id":2950,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/2313\/revisions\/2950"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=2313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=2313"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=2313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}