{"id":1838,"date":"2020-03-14T11:43:09","date_gmt":"2020-03-14T08:43:09","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=1838"},"modified":"2021-07-29T22:32:40","modified_gmt":"2021-07-29T20:32:40","slug":"%d1%81%d0%b5%d1%80%d0%b4%d0%b5%d1%87%d0%bd%d0%b0%d1%8f-%d0%bd%d0%b5%d0%b4%d0%be%d1%81%d1%82%d0%b0%d1%82%d0%be%d1%87%d0%bd%d0%be%d1%81%d1%82%d1%8c-%d1%83-%d0%b1%d0%be%d0%bb%d1%8c%d0%bd%d1%8b%d1%85-2","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/1838","title":{"rendered":"Heart failure in patients with diabetic cardiomyopathy: modern methods of treatment"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong><em>Prof. L.V. Zhuravlyova, N.V. Sokolnikova, T.A. Rogachova<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><strong><em>Kharkiv National Medical University<\/em><\/strong><\/p>\n<p style=\"text-align: justify;\"><strong><em>\u00a0<\/em><\/strong>Currently, all over the world, type 2 diabetes mellitus and the heart failure are developing into an epidemic. For the first time, diabetic cardiomyopathy as an independent diagnostic unit was described in 1972 by Shirley Rubler and colleagues. Currently, the most common phenotype of cardiomyopathy in diabetes is the restrictive type, which is characterized by the presence of diastolic left ventricular myocardial dysfunction and heart failure with preserved systolic function of the left ventricular myocardium. It was unexpected for the scientific world that tight glycemic control with insulin and sulfonylureas did not lead to the expected reduction in the risk of severe heart failure and cardiovascular death in type 2 diabetes mellitus. The effect of antidiabetic drugs on the risk of developing cardiovascular complications is being studied in an increasing number of clinical studies. In this review, we will try to summarize the main issues of the modern treatment of type 2 diabetes and the effect of sugar-lowering drugs on the development of heart failure.<\/p>\n<p style=\"text-align: justify;\"><strong>Key Words: <\/strong>diabetes mellitus, heart failure, diabetic cardiomyopathy, Metformin, glitazones, incretins, sodium glucose transporter inhibitors 2.<\/p>\n<p style=\"text-align: justify;\">https:\/\/dx.doi.org\/10.15407\/internalmed2020.01.022<\/p>\n<p style=\"text-align: justify;\"><a href=\"http:\/\/www.internalmed-journal.in.ua\/wp-content\/uploads\/2021\/07\/\u0416\u0443\u0440\u043d\u0430\u043b_1_2020-2-22-27.pdf\" target=\"_blank\">Download.PDF(rus)<\/a><\/p>\n<p style=\"text-align: justify;\">For citing:<\/p>\n<p style=\"text-align: justify;\">1. \u0416\u0443\u0440\u0430\u0432\u043b\u0435\u0432\u0430, \u041b.\u0412. \u0421\u0435\u0440\u0434\u0435\u0447\u043d\u0430\u044f \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0434\u0438\u0430\u0431\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043a\u0430\u0440\u0434\u0438\u043e\u043c\u0438\u043e\u043f\u0430\u0442\u0438\u0435\u0439: \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u043b\u0435\u0447\u0435\u043d\u0438\u044f \/ \u041b.\u0412. \u0416\u0443\u0440\u0430\u0432\u043b\u0435\u0432\u0430, \u041d.\u0412. \u0421\u043e\u043a\u043e\u043b\u044c\u043d\u0438\u043a\u043e\u0432\u0430, \u0422.\u0410. \u0420\u043e\u0433\u0430\u0447\u0435\u0432\u0430 \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. &#8211; 2020. &#8211; \u2116 1. &#8211; \u0421. 22-27. doi: 10.15407\/internalmed2020.01.02<\/p>\n<p style=\"text-align: justify;\">2. Zhuravlyova LV, Sokolnikova NV, Rogachova TA. [Heart failure in patients with diabetic cardiomyopathy: modern methods of treatment]. Shidnoevr. z. vnutr. simejnoi med. 2020;1:22-27. doi: 10.15407\/internalmed2020.01.022.<\/p>\n<p style=\"text-align: justify;\">References:<\/p>\n<p style=\"text-align: justify;\">1. Farmakis D, Stafylas P, Giamouzis G, Maniadakis N, Parissis J. The medical and socioeconomic burden of heart failure: A comparative delineation with cancer. International Journal of Cardiology. 2016;203:279-281. https:\/\/doi.org\/10.1016\/j.ijcard.2015.10.172<br \/>\nhttps:\/\/doi.org\/10.1016\/j.ijcard.2015.10.172<\/p>\n<p>2. Becher PM, Fluschnik N, Blankenberg S, Westermann D. Challenging aspects of treatment strategies in heart failure with preserved ejection fraction: &#8220;Why did recent clinical trials fail?&#8221;. World Journal of Cardiology. 2015;7(9):544. https:\/\/doi.org\/10.4330\/wjc.v7.i9.544<br \/>\nhttps:\/\/doi.org\/10.4330\/wjc.v7.i9.544<\/p>\n<p>3. Lombardi C, Spigoni V, Gorga E, Dei Cas A. Novel insight into the dangerous connection between diabetes and heart failure. Herz. 2016;41(3):201-207. https:\/\/doi.org\/10.1007\/s00059-016-4415-7<br \/>\nhttps:\/\/doi.org\/10.1007\/s00059-016-4415-7<\/p>\n<p>4. Kristensen SL, Mogensen UM, Jhund PS, Petrie MC, Preiss D, Win S, Kober L, McKelvie RS, Zile MR, Anand IS, Komajda M, Gottdiener JS, Carson PE, McMurray JJV. Clinical and Echocardiographic Characteristics and Cardiovascular Outcomes According to Diabetes Status in Patients With Heart Failure and Preserved Ejection Fraction. Circulation. 2017;135(8):724-735. https:\/\/doi.org\/10.1161\/circulationaha.116.024593<br \/>\nhttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.024593<\/p>\n<p>5. Dei C, Fonarow G, Gheorghiade M, Butler J. Concomitant Diabetes Mellitus and Heart Failure. Current Problems in Cardiology. 2015;40(1):7-43. https:\/\/doi.org\/10.1016\/j.cpcardiol.2014.09.002<br \/>\nhttps:\/\/doi.org\/10.1016\/j.cpcardiol.2014.09.002<\/p>\n<p>6. Seferovic P, Paulus W. Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes. European Heart Journal. 2015;36(27):1718-1727. https:\/\/doi.org\/10.1093\/eurheartj\/ehv134<br \/>\nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehv134<\/p>\n<p>7. Russo I, Frangogiannis N. Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities. Journal of Molecular and Cellular Cardiology. 2016;90:84-93. https:\/\/doi.org\/10.1016\/j.yjmcc.2015.12.011<br \/>\nhttps:\/\/doi.org\/10.1016\/j.yjmcc.2015.12.011<\/p>\n<p>8. Lambert R, Srodulski S, Peng X, Margulies KB, Despa F, Despa S. Intracellular Na + Concentration ([Na + ] i ) Is Elevated in Diabetic Hearts Due to Enhanced Na + -Glucose Cotransport. Journal of the American Heart Association. 2015;4(9). https:\/\/doi.org\/10.1161\/jaha.115.002183<br \/>\nhttps:\/\/doi.org\/10.1161\/JAHA.115.002183<\/p>\n<p>9. Pereira L, Ruiz-Hurtado G, Rueda A, Mercadier J, Benitah J, G\u00f3mez M. Calcium signaling in diabetic cardiomyocytes. Cell Calcium. 2014;56(5):372-380. https:\/\/doi.org\/10.1016\/j.ceca.2014.08.004<br \/>\nhttps:\/\/doi.org\/10.1016\/j.ceca.2014.08.004<\/p>\n<p>10. Taegtmeyer H, Beauloye C, Harmancey R, Hue L. Insulin resistance protects the heart from fuel overload in dysregulated metabolic states. American Journal of Physiology-Heart and Circulatory Physiology. 2013;305(12):1693-1697. https:\/\/doi.org\/10.1152\/ajpheart.00854.2012<br \/>\nhttps:\/\/doi.org\/10.1152\/ajpheart.00854.2012<\/p>\n<p>11. Eriksson L, Nystrom T. Antidiabetic Agents and Endothelial Dysfunction &#8211; Beyond Glucose Control. Basic &amp; Clinical Pharmacology &amp; Toxicology. 2015;117(1):15-25. https:\/\/doi.org\/10.1111\/bcpt.12402<br \/>\nhttps:\/\/doi.org\/10.1111\/bcpt.12402<\/p>\n<p>12. Rena G, Pearson E, Sakamoto K. Molecular mechanism of action of metformin: old or new insights? Diabetologia. 2013;56(9):1898-1906. https:\/\/doi.org\/10.1007\/s00125-013-2991-0<br \/>\nhttps:\/\/doi.org\/10.1007\/s00125-013-2991-0<\/p>\n<p>13. Amy R. Cameron, Vicky L. Morrison, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJK, Savinko T, Wong A, Viollet B, Sakamoto K, Fagerholm S, Foretz M, Lang C, Rena G. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circulation Research. 2016;119(5):652-665. https:\/\/doi.org\/10.1161\/circresaha.116.308445<br \/>\nhttps:\/\/doi.org\/10.1161\/CIRCRESAHA.116.308445<\/p>\n<p>14. Crowley M, Diamantidis C, McDuffie J, Cameron B, Stanifer J, Mock C, Wang X, Tang S, Nagi A, Kosinski A, Williams J. Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease. Annals of Internal Medicine. 2017;166(3):3-191. https:\/\/doi.org\/10.7326\/m16-1901<br \/>\nhttps:\/\/doi.org\/10.7326\/M16-1901<\/p>\n<p>15. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, Gonz\u00e1lez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P. ESC Scientific Document Group. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail. 2016:18;891-975. https:\/\/doi.org\/10.1093\/eurheartj\/ehw128<br \/>\nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehw128<\/p>\n<p>16. Goltsman I, Khoury E, Winaver J, Abassi Z. Does Thiazolidinedione therapy exacerbate fluid retention in congestive heart failure?. Pharmacology &amp; Therapeutics. 2016;168:75-97. http:\/\/dx.doi.org\/10.1016\/j.pharmthera.2016.09.007<br \/>\nhttps:\/\/doi.org\/10.1016\/j.pharmthera.2016.09.007<\/p>\n<p>17. Zhang Z, Zhang X, Korantzopoulos P, Letsas K, Tse G, Gong M, Meng L, Li G, Liu T. Thiazolidinedione use and atrial fibrillation in diabetic patients: a meta-analysis. BMC Cardiovascular Disorders. 2017;17(1). http:\/\/dx.doi.org\/10.1186\/s12872-017-0531-4<br \/>\nhttps:\/\/doi.org\/10.1186\/s12872-017-0531-4<\/p>\n<p>18. Hernandez A, Usmani A, Rajamanickam A, Moheet A. Thiazolidinediones and risk of heart failure in patients with or at high risk of type 2 diabetes mellitus: a meta-analysis and meta-regression analysis of placebo-controlled randomized clinical trials. American Journal Cardiovascular Drugs. 2011;11(2):115-128. http:\/\/dx.doi.org\/10.2165\/11587580-000000000-00000.<br \/>\nhttps:\/\/doi.org\/10.2165\/11587580-000000000-00000<\/p>\n<p>19. Toprani A, Fonseca V. Thiazolidinediones and congestive heart failure in veterans with type 2 diabetes. Diabetes, Obesity and Metabolism. 2011;13(3):276-280. http:\/\/dx.doi.org\/10.1111\/j.1463-1326.2010.01348.x<br \/>\nhttps:\/\/doi.org\/10.1111\/j.1463-1326.2010.01348.x<\/p>\n<p>20. Erdmann E, Charbonnel B, Wilcox R, Skene A, Massi-Benedetti M, Yates J, Tan M, Spanheimer R, Standl E, Dormandy J. Pioglitazone Use and Heart Failure in Patients With Type 2 Diabetes and Preexisting Cardiovascular Disease: Data from the PROactive Study (PROactive 08). Diabetes Care. 2007;30(11):2773-2778. http:\/\/dx.doi.org\/10.2337\/dc07-0717<br \/>\nhttps:\/\/doi.org\/10.2337\/dc07-0717<\/p>\n<p>21. Marso S, Daniels G, Brown-Frandsen K, Kristensen P, Mann J, Nauck M, Nissen S, Pocock S, Poulter N, Ravn L, Steinberg W, Stockner M, Zinman B, Bergenstal R, Buse J. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. New England Journal of Medicine. 2016;375(4):311-322. http:\/\/dx.doi.org\/10.1056\/nejmoa1603827<br \/>\nhttps:\/\/doi.org\/10.1056\/NEJMoa1603827<\/p>\n<p>22. Ussher J, Baggio L, Campbell J, Mulvihill E, Kim M, Kabir M, Cao X, Baranek B, Stoffers D, Seeley R, Drucker D. Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection. Molecular Metabolism. 2014;3(5):507-517. http:\/\/dx.doi.org\/10.1016\/j.molmet.2014.04.009<br \/>\nhttps:\/\/doi.org\/10.1016\/j.molmet.2014.04.009<\/p>\n<p>23. Green J, Bethel M, Armstrong P, Buse J, Engel S, Garg J, Josse R, Kaufman K, Koglin J, Korn S, Lachin J, McGuire D, Pencina M, Standl E, Stein P, Suryawanshi S, Van de Werf F, Peterson E, Holman R. Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes. New England Journal of Medicine. 2015;373(3):232-242. http:\/\/dx.doi.org\/10.1056\/nejmoa1501352<br \/>\nhttps:\/\/doi.org\/10.1056\/NEJMoa1501352<\/p>\n<p>24. Jorsal A, Kistorp C, Holmager P, Tougaard R, Nielsen R, H\u00e4nselmann A, Nilsson B, M\u00f8ller J, Hjort J, Rasmussen J, Boesgaard T, Schou M, Videbaek L, Gustafsson I, Flyvbjerg A, Wiggers H, Tarnow L. Effect of liraglutide, a glucagon-like peptide-1 analogue, on left ventricular function in stable chronic heart failure patients with and without diabetes (LIVE)-a multicentre, double-blind, randomised, placebo-controlled trial. European Journal of Heart Failure. 2016;19(1):69-77. http:\/\/dx.doi.org\/10.1002\/ejhf.657.<br \/>\nhttps:\/\/doi.org\/10.1002\/ejhf.657<\/p>\n<p>25. Margulies K, Hernandez A, Redfield M, Givertz M, Oliveira G, Cole R, Mann D, Whellan D, Kiernan M, Felker G, McNulty S, Anstrom K, Shah M, Braunwald E, Cappola T. Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction. JAMA. 2016;316(5):500. http:\/\/dx.doi.org\/10.1001\/jama.2016.10260<br \/>\nhttps:\/\/doi.org\/10.1001\/jama.2016.10260<\/p>\n<p>26. Heerspink H, Perkins B, Fitchett D, Husain M, Heerspink H, Perkins B, Fitchett D, Husain M, Cherney D. Sodium glucose cotransporter 2 inhibitors in the treatment of diabetes mellitus: cardiovascular and kidney effects, potential mechanisms, and clinical applications. Circulation. 2016;134(10):752-772. http:\/\/dx.doi.org\/10.1161\/circulationaha.116.021887.<br \/>\nhttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.021887<\/p>\n<p>27. Ferrannini E, Muscelli E, Frascerra S, Baldi S, Mari A, Heise T, Broedl U, Woerle H. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. Journal of Clinical Investigation. 2014;124(4):499-508. http:\/\/dx.doi.org\/10.1172\/jci75754<br \/>\nhttps:\/\/doi.org\/10.1172\/JCI75754<\/p>\n<p>28. Baartscheer A, Schumacher C, W\u00fcst R, Fiolet J, Stienen G, Coronel R, Zuurbier C. Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+\/H+ exchanger in rats and rabbits. Diabetologia. 2016;60(3):568-573. http:\/\/dx.doi.org\/10.1007\/s00125-016-4134-x<br \/>\nhttps:\/\/doi.org\/10.1007\/s00125-016-4134-x<\/p>\n<p>29. Clancy C, Chen-Izu Y, Bers D, Belardinelli L, Boyden P, Csernoch L, Despa S, Fermini B, Hool L, Izu L, Kass R, Lederer W, Louch W, Maack C, Matiazzi A, Qu Z, Rajamani S, Rippinger C, Sejersted O, O&#8217;Rourke B, Weiss J, Varr\u00f3 A, Zaza A. Deranged sodium to sudden death. The Journal of Physiology. 2015;593(6):1331-1345. http:\/\/dx.doi.org\/10.1113\/jphysiol.2014.281204<br \/>\nhttps:\/\/doi.org\/10.1113\/jphysiol.2014.281204<\/p>\n<p>30. Chilton R, Tikkanen I, Cannon C, Crowe S, Woerle H, Broedl U, Johansen O. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes, Obesity and Metabolism. 2015;17(12):1180-1193. http:\/\/dx.doi.org\/10.1111\/dom.12572<br \/>\nhttps:\/\/doi.org\/10.1111\/dom.12572<\/p>\n<p>31. Bavry A, Bhatt D. Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction &#8211; DAPA-HF. American College of Cardiology. 2019.<\/p>\n<p>32. McMurray J, Solomon S, Docherty K, Jhund P. The Dapagliflozin And Prevention of Adverse outcomes in Heart Failure trial (DAPA-HF) in context. European Heart Journal. 2020. http:\/\/dx.doi.org\/10.1093\/eurheartj\/ehz916<br \/>\nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehz916<\/p>\n<p>33. Singh J, Fathi A, Vickneson K, Mordi I, Mohan M, Houston J, Pearson E, Struthers A, Lang C. Research into the effect Of SGLT2 inhibition on left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM) trial rationale and design. Cardiovascular Diabetology. 2016;15(1):97. http:\/\/dx.doi.org\/10.1186\/s12933-016-0419-0<br \/>\nhttps:\/\/doi.org\/10.1186\/s12933-016-0419-0<\/p>\n<p>34. van Melle J, Bot M, de Jonge P, de Boer R, van Veldhuisen D, Whooley M. Diabetes, Glycemic Control, and New-Onset Heart Failure in Patients With Stable Coronary Artery Disease: Data from the Heart and Soul Study. Diabetes Care. 2010;33(9):2084-2089. http:\/\/dx.doi.org\/10.2337\/dc10-0286<br \/>\nhttps:\/\/doi.org\/10.2337\/dc10-0286<\/p>\n<p>35. Belovol AN, Knjaz&#8217;kova II. Serdechno-sosudistye zabolevanija i saharnyj diabet. Diabetologija. Tireodologija. Metabolicheskie rasstrojstva. 2013;3\/4:30-32. Russian.<\/p>\n<p>36. Zhuravlyova LV, Sokol&#8217;nikova NV, Filonenko MV, Rogachova TA. Interlejkin-1\u03b2 i interlejkin-6 novye markery metabolicheskih narushenij pri saharnom diabete 2 tipa . Georgian Medical News. 2019;2:82-86. Russian.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Prof. L.V. Zhuravlyova, N.V. Sokolnikova, T.A. Rogachova Kharkiv National Medical University \u00a0Currently, all over the world, type 2 diabetes mellitus and the heart failure are developing into an epidemic. For the first time, diabetic cardiomyopathy as an independent diagnostic unit was described in 1972 by Shirley Rubler and colleagues. Currently, the most common phenotype of&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,9,24,50],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":true,"content":true,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1838"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=1838"}],"version-history":[{"count":5,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1838\/revisions"}],"predecessor-version":[{"id":2505,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1838\/revisions\/2505"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=1838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=1838"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=1838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}