{"id":1673,"date":"2019-11-14T22:03:58","date_gmt":"2019-11-14T19:03:58","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=1673"},"modified":"2020-03-23T15:47:55","modified_gmt":"2020-03-23T12:47:55","slug":"%d1%8d%d1%80%d0%be%d0%b7%d0%b8%d0%b2%d0%bd%d0%b0%d1%8f-%d0%b8-%d0%bd%d0%b5%d1%8d%d1%80%d0%be%d0%b7%d0%b8%d0%b2%d0%bd%d0%b0%d1%8f-%d1%84%d0%be%d1%80%d0%bc%d1%8b-%d0%b3%d0%b0%d1%81%d1%82%d1%80%d0%be","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/1673","title":{"rendered":"\u0415rosive and non-erosive forms of gastroesophageal reflux disease"},"content":{"rendered":"

Prof. T.D. Zvyagintseva , as.<\/strong>prof.<\/strong> Ya.K. Gamanenko\u00a0<\/strong><\/p>\n

Kharkiv Academy of Postgraduate Medicine<\/strong><\/p>\n

The article deals with the issues of modern understanding of cellular and molecular mechanisms of the pathogenesis of GERD-associated inflammation of the esophagus mucosa involves complex and multifactorial immune-mediated effects of re-action of gastric reflux contents with varying pH values. Until recently, the change in the daily pH-metric index in the acid side was clearly associated with the presence of reflux esophagitis. However, it has appeared that the association of acid action and the manifestation of symptoms in patients isot always reliable. Currently, the available spectrum of studies allows the isolation of individual phenotypes of GERD and NERD and to determine the optimal therapies based on additional methods of research and evaluation of the impedance of the esophagus mucosa, manometry, histopathological methods and psychometry. Extensions of ideas about the mechanisms of formation and progress of GERD puts certain tasks in the allocation of the most reliable methods of diagnosis of the disease, which in the next will determine the mostrational approaches to the treatment of patients and prevention of the development of such complications of GERD as erosion esophagitis, Barrett\u2019s esophagus and adenocarcinoma of the esophagus.<\/p>\n

Key Words:<\/strong> gastroesophageal reflux disease, non-erosive reflux disease, Barrett\u2019s esophagus, \u041d.pylori, protonpump inhibitors, esophagogastroscopy.<\/p>\n

https:\/\/dx.doi.org\/10.15407\/internalmed2019.02.042<\/a><\/p>\n

Download.PDF<\/a><\/strong><\/p>\n

For citing:<\/strong><\/p>\n

    \n
  1. \u0417\u0432\u044f\u0433\u0456\u043d\u0446\u0435\u0432\u0430, \u0422.\u0414. \u0415\u0440\u043e\u0437\u0438\u0432\u043d\u0430 \u0442\u0430 \u043d\u0435\u0435\u0440\u043e\u0437\u0438\u0432\u043d\u0430 \u0433\u0430\u0441\u0442\u0440\u043e\u0435\u0437\u043e\u0444\u0430\u0433\u0435\u0430\u043b\u044c\u043d\u0430 \u0440\u0435\u0444\u043b\u044e\u043a\u0441\u043d\u0430 \u0445\u0432\u043e\u0440\u043e\u0431\u0430: \u0441\u0443\u0447\u0430\u0441\u043d\u0456 \u0442\u0435\u043d\u0434\u0435\u043d\u0446\u0456\u0457 \u0432 \u0434\u0456\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u0446\u0456 \u0442\u0430 \u043b\u0456\u043a\u0443\u0432\u0430\u043d\u043d\u0456 \/ \u0422.\u0414. \u0417\u0432\u044f\u0433\u0456\u043d\u0446\u0435\u0432\u0430, \u042f.\u041a. \u0413\u0430\u043c\u0430\u043d\u0435\u043d\u043a\u043e \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. – 2019. – \u2116 2. – \u0421. 42-49. doi: 10.15407\/internalmed2019.02.042<\/li>\n
  2. Zvyagintseva TD, Gamanenko YaK. [Erosive And Non-Erosive Forms Of Gastroesophageal Reflux Disease]. Shidnoevr. z. vnutr. simejnoi med. 2019;2:42-49. doi: 10.15407\/internalmed2019.02.042. Ukrainian.<\/li>\n<\/ol>\n

    References:<\/p>\n

    1. Borodyn DS, Kolbasnykov SV. Ghastroezofaghealjnaja refljuksnaja boleznj ot patogheneza k lechenyju. Lechashhyj vrach. 2016;7:34-37. Russian.<\/p>\n

    2. Eremyna EJu, Zvereva SY, Rjazanceva DE, Rjabova EA. Lechenye pacyentov s ghastroezofaghealjnoj refljuksnoj boleznjju. Vse ly voprosy resheny? Klynycheskye perspektyvu ghastroenterologhyy, ghepatologhyy. 2018;5:32-39. Russian.<\/p>\n

    3. Zvjaghinceva TD, Serghijenko OI, Chernobaj AI, Sharghorod II, Ghridneva SV, Ghamanenko JaK. Zakhvorjuvannja orghaniv travlennja: navchaljnyj posibnyk dlja likariv-ghastroenterologhiv, terapevtiv, likariv zaghaljnoji praktyky – simejnoji medycyny, infekcionistiv,terapevtiv. Kharkiv (Ukrajina): Drukarnja Madryd. 2014. 304 p. Ukrainian.<\/p>\n

    4. Ljamyna SV, Kladovykova OV. Ghastroezofaghealjnaja refljuksnaja boleznj: sovremennye tendencyy v dyaghnostyke y lechenyy. Ghastroenterologhyja. 2018;2:33-38. Russian.<\/p>\n

    5. Krylova OO, Alejnyk DV, Kuznecov GhE, Chekan LO. Chastota cylindrychnoji metaplaziji slyzovoji obolonky stravokhodu u khvorykh na GhERKh. Ukr. Zhurnal maloinvazyvnoji ta endoskopichnoji endoskopichnoji khirurghiji. 2016;20;22-34. Ukrainian.<\/p>\n

    6. Mishhuk VGh, Bojchuk VB. Rivenj ghastrynu v krovi u khvorykh na GhERKh ta kharakter ezofaghealjnykh refljuksiv. Suchasna ghastroenterologhija. 2014;3:16-22. Ukrainian.<\/p>\n

    7. Nikishajev VI. Tekhnologhichni karty ta indykatory jakosti endoskopichnykh vtruchanj. [Internet] 2015 [cited 2019 Mar 01]. Available from: http:endoscopy com. ua vracham rekomendacyy – assocyacyy tekhnologhichni karty ta indykatory jakosti. Ukrainian.<\/p>\n

    8. Pakhomova YGh, Baryshnykova NV. Sovremennyj vzghljad na terapyju GhERB: vozmozhnosty patoghenetycheskoj y symptomatycheskoj terapyy. RMZh \u00abMedycynskoe obozrenye\u00bb. 2019;3. Russian.<\/p>\n

    9. Fass R, Frejder R. Rolj dekslansoprazola s modyfycyrovannym vysvobozhdenyem v lechenyy ghastroezofaghealjnoj refljuksnoj bolezny. Zdorov’ja Ukrajiny. 2018;2: 21-24. Russian.
    \nhttps:\/\/doi.org\/10.1007\/s41193-018-0170-x<\/p>\n

    10. Stepanov JuM, Budzak NJa. Soderzhanye syvorotochnogho ghastryna u pacyentov refrakternoj y antysekretornoj terapyy formamy ghastroezofaghealjnoj refljuksnoj bolezny. RZhGhGhK. 2015;5 (vol. 20):18. Russian.<\/p>\n

    11. Tkach SM. Vedenye boljnykh ghastroezofaghealjnoj boleznjju v svete poslednegho amerykanskogho konsensusa. Ghastroenterologhija. 2013; 2:108-113. Russian.<\/p>\n

    12. Chernobrovyj VM, Melashhenko SGh, Ksenchyn OO. Ghastroezofaghealjna refljuksna khvoroba: funkcionaljna diaghnostyka, vybir inghibitoriv protonnoji pompy ta ocinka efektyvnosti jikh kyslotosupresyvnoji diji. Suchasna ghastroenterologhija. 2017;3:50-60. Ukrainian.<\/p>\n

    13. Sheptulyn AA. Novaja systema ocenky klynycheskykh symptomov ghastroezofaghealjnoj refljuksnoj bolezny. RZhGhGhK. 2018;4:23-27. Ukrainian.<\/p>\n

    14. Beaumont H, Bennink RJ, Jong J, Boeckxstaens GE. The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD. Gut. 2017; 59: 441-451. doi:10.1007\/s10353-009-0489-2
    \nhttps:\/\/doi.org\/10.1007\/s10353-009-0489-2<\/p>\n

    15. Boeckxstaens G.E. Reflux inhibitors: a new approach for GARB. Curr. Opin. Pharmacol. 2018;8:685-689. doi:10.1016\/j.coph.2008.08.005
    \nhttps:\/\/doi.org\/10.1016\/j.coph.2008.08.005<\/p>\n

    16. Dent J. Vakil N . Jones R, P. Bytzer, U. Schoning, K. Halling, O. Junghard, T. Lind. Accuracy of the diagnosis of GORD by guestionnaire, physicians and a trial of proton pump inhibitor treatment: the Diamond Study. Gut. 2014;59:714-721. doi:10.1136\/gut.2009.200063
    \nhttps:\/\/doi.org\/10.1136\/gut.2009.200063<\/p>\n

    17. Fass R., Gasiorowska A. Refractory GERD : what is it? Curr. Gastroenterol. 2016;10:252 – 257. doi:10.1007\/s11894-008-0052-5
    \nhttps:\/\/doi.org\/10.1007\/s11894-008-0052-5<\/p>\n

    18. Karamanolis G, Sifrim D. Developmants in Phatogenesis and Diagnosis of Gastroesophageal Reflux Disease. Curr. Opion. Gastroenterol. 2017;23 (4): 428 – 433. doi:10.1097\/mog.0b013e328133f56a
    \nhttps:\/\/doi.org\/10.1097\/MOG.0b013e328133f56a<\/p>\n

    19. Kahrilas PJ, Shi G, Manka M, Joehl RJ. Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. Gastroenterology. 2000;118 (4): 688-695. doi:10.1016\/s0016-5085(00)70138-7
    \nhttps:\/\/doi.org\/10.1016\/S0016-5085(00)70138-7<\/p>\n

    20. Kinoshita Y, Ashida K, Miwa H, Hongo M. The impact of live style modification on the health -related quality of life of patients with reflux esophagitis receiving treatment with a proton pump inhibitor. Am. J. Gastroenterol. 2017;104 (5):1106 – 1111. doi:10.1038\/ajg.2009.77
    \nhttps:\/\/doi.org\/10.1038\/ajg.2009.77<\/p>\n

    21. Fock KM, Talley N, Goh KL, Sugano K, Katelaris P, Holtmann G, Pandolfino JE, Sharma P, Ang TL, Hongo M, Wu J, Chen M, Choi MG, Law NM, Sheu BS, Zhang J, Ho KY, Sollano J, Rani AA, Kositchaiwat C, Bhatia S. Asia-Pacific consensus on the management of gastroesophageal reflux disease: Update. J. Gastroenterology and Hepatology. 2016;23:8-22. doi:10.1038\/ajg.2009.77
    \nhttps:\/\/doi.org\/10.1038\/ajg.2009.77<\/p>\n

    22. Hampel H, Abraham NS, El Serag HB. Metaanalysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann.Intern. Med. 2015; 143:199-211. doi:10.7326\/0003-4819-143-3-200508020-00006
    \nhttps:\/\/doi.org\/10.7326\/0003-4819-143-3-200508020-00006<\/p>\n

    23. Hershcovici \u0422, Fass R. Nonerosive Reflux Disease (NERD) – An Update. J. Neurogastroenterol. Motil. 2015; 16: 8-21. doi:10.5056\/jnm.2010.16.1.8
    \nhttps:\/\/doi.org\/10.5056\/jnm.2010.16.1.8<\/p>\n

    24. \u041d. Inoue, Malfertheiner P, Megraud F, O’Morain CA, Hungin APS, Jones R, Axon A, Graham DY, Tytgat G. Management of Helicobacter pylori infection – the Maastricht V\/Florence Consensus Report. Gut. 2018; 61: 646-664. doi:10.1046\/j.1365-2036.2002.01169.x
    \nhttps:\/\/doi.org\/10.1046\/j.1365-2036.2002.01169.x<\/p>\n

    25. Miwa \u041d, Moore JM, Vaezi MF. Extraesophageal manifetationof gastroesophageal reflux disease: real or imagined? Gurr Opin Gastroenteral 2016;26:389-394. doi:10.1097\/mog.0b013e32833adc8d
    \nhttps:\/\/doi.org\/10.1097\/MOG.0b013e32833adc8d<\/p>\n

    26. Male C, Tootsen N, Krown P, Nounford R. Prymenenye omeprazola 10 mgh v profylaktyke recydyva refljuks-ezofaghyta. J. Gastroenterology. 2018; 4:49 – 55.<\/p>\n

    27. Moayyedi P, Talley NJ. Ghastroezofaghealjnaja refljuksnaja boleznj. Therapia. 2017; 2:13 – 25.<\/p>\n

    28. Pandolfino JE, Zhang QG, Ghosh SK, Han A, Boniquit C, Kahrilas PJ. Transient lower esophageal sphincter relaxations and reflux: mechanistic analysis using concurrent fluoroscopy and high-resolution manometry. Gastroenterology. 2016;131:1725-1733. doi:10.1053\/j.gastro.2006.09.009
    \nhttps:\/\/doi.org\/10.1053\/j.gastro.2006.09.009<\/p>\n

    29. Sandhu DS, Fass R. Current Trends in the Management of Gastroesophageal Reflux Disease. Gut and Liver. 2018;12(1):7-16. doi:10.5009\/gnl16615
    \nhttps:\/\/doi.org\/10.5009\/gnl16615<\/p>\n

    30. Shaheen N, Falk GW, Iyer PG, Gerson LB, American College of Gastroenterology. ACG clinical guideline: diagnosis and management of Barret’s esophagus. The American journal of gastroenterology. 2016;11(1):30-50. doi:10.1038\/ajg.2015.322
    \nhttps:\/\/doi.org\/10.1038\/ajg.2015.322<\/p>\n","protected":false},"excerpt":{"rendered":"

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