{"id":1652,"date":"2019-11-14T21:10:51","date_gmt":"2019-11-14T18:10:51","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=1652"},"modified":"2020-03-23T15:31:38","modified_gmt":"2020-03-23T12:31:38","slug":"%d1%81%d0%b5%d1%80%d0%b4%d0%b5%d1%87%d0%bd%d0%b0%d1%8f-%d0%bd%d0%b5%d0%b4%d0%be%d1%81%d1%82%d0%b0%d1%82%d0%be%d1%87%d0%bd%d0%be%d1%81%d1%82%d1%8c-%d1%83-%d0%b1%d0%be%d0%bb%d1%8c%d0%bd%d1%8b%d1%85","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/1652","title":{"rendered":"Heart failure in patients with diabetic cardiomyopathy: features of pathogenesis and diagnosis"},"content":{"rendered":"

Prof. L.V. Zhuravlyova, as. prof. T.A. Rogachova, as. prof.\u00a0N.V. Sokolnikova.<\/strong><\/p>\n

Kharkiv National Medical University<\/strong><\/p>\n

Currently, all over the world, type 2 diabetes mellitus and the heart failure are developing into an epidemic. In 1972, Shirley Rubler and colleagues defined cardiomyopathy, which was independent of atherosclerosis and hypertension, as diabetic cardiomyopathy. Recently, the so-called restrictive type has become more commonphenotype of diabetic cardiomyopathy: with the presence of diastolic dysfunction, with heart failure withpreserved systolic function of the left ventricle. New mechanisms for the development of heart failure in diabeticcardiomyopathy were also identified: microvascular endothelial dysfunction, leading to impaired vasodilationwith increased oxygen demand in the myocardium, and impaired free fatty acids metabolism, leading toimpaired adenosine triphosphoric acid synthesis in cardiomyocytes. Here we summarize the key questions byproviding an overview of current data.<\/p>\n

Key Words<\/strong>: diabetes mellitus, heart failure, insulin resistance, diastolic dysfunction, diabetic cardiomyopathy, microvascular endothelial dysfunction, free fatty acids.<\/p>\n

https:\/\/dx.doi.org\/10.15407\/internalmed2019.02.012<\/a><\/p>\n

Download.PDF<\/a><\/p>\n

For citing:<\/p>\n

    \n
  1. \u0416\u0443\u0440\u0430\u0432\u043b\u0435\u0432\u0430, \u041b.\u0412. \u0421\u0435\u0440\u0434\u0435\u0447\u043d\u0430\u044f \u043d\u0435\u0434\u043e\u0441\u0442\u0430\u0442\u043e\u0447\u043d\u043e\u0441\u0442\u044c \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0434\u0438\u0430\u0431\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043a\u0430\u0440\u0434\u0438\u043e\u043c\u0438\u043e\u043f\u0430\u0442\u0438\u0435\u0439: \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e\u0441\u0442\u0438 \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0430 \u0438 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0438 \/ \u041b.\u0412. \u0416\u0443\u0440\u0430\u0432\u043b\u0435\u0432\u0430, \u0422.\u0410. \u0420\u043e\u0433\u0430\u0447\u0435\u0432\u0430, \u041d.\u0412. \u0421\u043e\u043a\u043e\u043b\u044c\u043d\u0438\u043a\u043e\u0432\u0430 \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. – 2019. – \u2116 2. – \u0421. 12-17. doi: 10.15407\/internalmed2019.02.012.<\/li>\n
  2. Zhuravlyova LV, Rogachova TA, Sokolnikova NV. [Heart Failure In Patients With Diabetic Cardiomyopathy: Pathogenesis, Diagnosis, Treatment]. Shidnoevr. z. vnutr. simejnoi med. 2019;2:12-17. doi: 10.15407\/internalmed2019.02.012. Russian.<\/li>\n<\/ol>\n

    References:<\/p>\n

    1. Farmakis D, Stafylas P, Giamouzis G, Maniadakis N, Parissis J.The medical and socioeconomic burden of heart failure: a comparative delineation with cancer. Int J Cardiol.2016;203:279-281. DOI:10.1016\/j.ijcard. 2015.10.172
    \nhttps:\/\/doi.org\/10.1016\/j.ijcard.2015.10.172<\/p>\n

    2. Becher P, Fluschnik N, Blankenberg S, Westermann D. Challenging aspects of treatment strategies in heart failure with preserved ejection fraction: “Why did recent clinical trials fail?”. World J Cardiol. 2015;7:544. DOI:10.4330\/wjc.v7.i9.544
    \nhttps:\/\/doi.org\/10.4330\/wjc.v7.i9.544<\/p>\n

    3. Lombardi C, Spigoni V, Gorga E, Cas AD. Novel insight into the dangerous connection between diabetes and heart failure. Herz.2016;41:201-207. DOI:10.1007\/s00059-016-4415-7
    \nhttps:\/\/doi.org\/10.1007\/s00059-016-4415-7<\/p>\n

    4. Kristensen S, Mogensen U, Jhund P, Petrie MC, Preiss D, Win S, K\u00f8ber L, McKelvie RS, Zile MR, Anand IS, Komajda M, Gottdiener JS, Carson PE, McMurray JJ. Clinical and echocardiographic characteristics and cardiovascular outcomes according to diabetes status in patients with heart failure and preserved ejection fraction: a report from the I-Preserve Trial (Irbesartan in Heart Failure With Preserved Ejection Fraction). Circulation. 2017;135:724-735. DOI:10.1161\/circulationaha.116.024593
    \nhttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.024593<\/p>\n

    5. Dei C, Fonarow G, Gheorghiade M, Butler J. Concomitant diabetes mellitus and heart failure. Curr Probl Cardiol.2015;40:7-43. DOI:10.1016\/j.cpcardiol.2014.09.002
    \nhttps:\/\/doi.org\/10.1016\/j.cpcardiol.2014.09.002<\/p>\n

    6. Seferovic P, Paulus W. Clinical diabetic cardiomyopathy: a two-faced disease with restrictive and dilated phenotypes. Eur Heart J. 2015;36:1718-1727.DOI:10.1093\/eurheartj\/ehv134
    \nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehv134<\/p>\n

    7. Russo I, Frangogiannis N. Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities. J Mol Cell Cardiol.2016;90:84-93. DOI:10.1016\/j.yjmcc. 2015.12.011
    \nhttps:\/\/doi.org\/10.1016\/j.yjmcc.2015.12.011<\/p>\n

    8. Lambert R, Srodulski S, Peng X, Margulies KB, Despa F, Despa F Intracellular Na+ concentration is elevated in diabetic hearts due to enhanced Na+-glucose cotransport. J Am Heart Assoc.2015;4. DOI:10.1161\/jaha.115.002183.
    \nhttps:\/\/doi.org\/10.1161\/JAHA.115.002183<\/p>\n

    9. Pereira L, Ruiz-Hurtado G, Rueda A, Mercadier J, Benitah JP, G\u00f3mez AM. Calcium signaling in diabetic cardiomyocytes. Cell Calcium. 2014;56:372-380.DOI:10.1016\/j.ceca.2014.08.004
    \nhttps:\/\/doi.org\/10.1016\/j.ceca.2014.08.004<\/p>\n

    10. Bertero E, Maack C. Calcium signaling and reactive oxygen species in mitochondria. Circ Res. 2018;122:1460-1478. DOI:10.1161\/circresaha.118.310082
    \nhttps:\/\/doi.org\/10.1161\/CIRCRESAHA.118.310082<\/p>\n

    11. Bertero E, Roma L, Ameri P, Christoph Maack. Cardiac effects of SGLT2 inhibitors: the sodium hypothesis. Cardiovasc Res. 2018;114:12-18.DOI:10.1093\/cvr\/cvx149
    \nhttps:\/\/doi.org\/10.1093\/cvr\/cvx149<\/p>\n

    12. Gadde K, Martin C, Berthoud H, Steven B. Heymsfield Obesity: pathophysiology and management\u044e J Am Coll Cardiol. 2018;71:69-84. DOI:10.1016\/j.jacc.2017.11.011
    \nhttps:\/\/doi.org\/10.1016\/j.jacc.2017.11.011<\/p>\n

    13. Bertero E, Maack C. Metabolic remodeling in heart failure. Nat Rev Cardiol.2018. DOI:10.1038\/s41569-018-0044-6
    \nhttps:\/\/doi.org\/10.1038\/s41569-018-0044-6<\/p>\n

    14. Cadenas S. Mitochondrial uncoupling, ROS generation and cardioprotection. Biochim Biophys Acta. 2018;1859:940-950. DOI:10.1016\/j.bbabio.2018.05.019
    \nhttps:\/\/doi.org\/10.1016\/j.bbabio.2018.05.019<\/p>\n

    15. Bedi K, Snyder N, Brandimarto J, Aziz M, Mesaros C, Worth AJ, Wang LL, Javaheri A, Blair IA, Kenneth B, Eduardo MJ. Rame Evidence for intramyocardial disruption of lipid metabolism and increased myocardial ketone utilization in advanced human heart failure. Circulation 2016;133:706-716.DOI:10.1161\/circulationaha.115.017545
    \nhttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.115.017545<\/p>\n

    16. Taegtmeyer H, Beauloye C, Harmancey R, Hue L. Insulin resistance protects the heart from fuel overload in dysregulated metabolic states. Am J Physiol Heart Circ Physiol. 2013;305:1693-1697. DOI:10.1152\/ajpheart.00854.2012
    \nhttps:\/\/doi.org\/10.1152\/ajpheart.00854.2012<\/p>\n

    17. Lim S, Lam C, Segers V, Brutsaert DL, Gilles W. De KeulenaerCardiac endothelium-myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction. Eur Heart J. 2015;36:2050-2060. DOI:10.1093\/eurheartj\/ehv132
    \nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehv132<\/p>\n

    18. Eriksson L, Nystrom T. Antidiabetic agents and endothelial dysfunction-beyond glucose control. Basic Clin Pharmacol Toxicol.2015;117:15-25. DOI:10.1111\/bcpt.12402
    \nhttps:\/\/doi.org\/10.1111\/bcpt.12402<\/p>\n

    19. Ponikowski P, Voors A, Anker S, BuenoH, Cleland JG, Coats AJ, Falk V, Gonz\u00e1lez-Juanatey JR, Harjola V, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH. ESC Scientific Document Group. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail.2016;18:891-975. https:\/\/doi.org\/10.5603\/kp.2016.0141.
    \nhttps:\/\/doi.org\/10.5603\/KP.2016.0141<\/p>\n

    20. Kenny H, Abel E. Heart failure in type 2 diabetes mellitus. Circulation Research.2019;124(1):121-141. DOI:10.1161\/circresaha.118.311371
    \nhttps:\/\/doi.org\/10.1161\/CIRCRESAHA.118.311371<\/p>\n

    21. Holscher M, Bode C, Bugger H. Diabetic Cardiomyopathy: Does the Type of Diabetes Matter? Int J Mol Sci.2016;17(12):2136. DOI:10.3390\/ijms17122136
    \nhttps:\/\/doi.org\/10.3390\/ijms17122136<\/p>\n

    22. Jia G, Hill M, Sowers J. Diabetic Cardiomyopathy. An Update of Mechanisms Contributing to This Clinical Entity. Circulation Research.2018;122:624-638. DOI:10.1161\/circresaha.117.311586
    \nhttps:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311586<\/p>\n

    23. Kuri L, Smail M, Qureshi M, Sydorenko V, Shmygol, Oz M, Singh J, Howarth FC. Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat. Journal of Diabetes Research.2018. DOI:10.1155\/2018\/2974304.
    \nhttps:\/\/doi.org\/10.1155\/2018\/2974304<\/p>\n

    24. Maack C, Lehrke M, Backs J, Heinzel FR, Hulot J, Marx N, Paulus W, Rossignol P, Taegtmeyer H, Bauersachs J, Bayes-Genis A, Brutsaert D, Bugger H, Clarke K, Cosentino F, De Keulenaer G, Cas AD, Gonz\u00e1lez A, Huelsmann M, Iaccarino G, Lunde IG, Lyon AR, Pollesello P, Rena G, Riksen NP, Rosano G, Staels G, van Laake LW, Wanner C, Farmakis D, Filippatos G, Ruschitzka F, Seferovic P, de Boer RA, Heymans S. Heart failure and diabetes: metabolic alterations and therapeutic interventions: a stateof-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology. European Heart Journal.2018;39(48):4243-4254. DOI:10.1093\/eurheartj\/ehy596
    \nhttps:\/\/doi.org\/10.1093\/eurheartj\/ehy596<\/p>\n

    25. Gibb A, Hill B. Metabolic Coordination of Physiological and Pathological Cardiac Remodeling. Circulation Research.2018;123:107-128DOI:10.1161\/circresaha.118.312017
    \nhttps:\/\/doi.org\/10.1161\/CIRCRESAHA.118.312017<\/p>\n

    26. Lee W, Kim J. Diabetic cardiomyopathy: where we are and where we are going. Korean J Intern Med.2017;32(3):404-421. DOI:10.3904\/kjim.2016.208
    \nhttps:\/\/doi.org\/10.3904\/kjim.2016.208<\/p>\n

    27. Levelt E, Gulsin G. mechanisms in endocrinology: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review. European Journal of Endocrinology.2018;178(4):127-139. DOI:10.1530\/eje-17-0724
    \nhttps:\/\/doi.org\/10.1530\/EJE-17-0724<\/p>\n

    28. Nakamura M, Sadoshima J. Cardiomyopathy in obesity, insulin resistance and diabetes. The Journal of Physiology.2019.DOI:10.1113\/jp276747
    \nhttps:\/\/doi.org\/10.1113\/JP276747<\/p>\n

    29. McHugh K, DeVore A, Wu J. Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-theArt Review. J Am Coll Cardiol.2019;73(5):602-611. DOI:10.1016\/j.jchf.2018.12.017
    \nhttps:\/\/doi.org\/10.1016\/j.jchf.2018.12.017<\/p>\n

    30. Lindman R. The Diabetic Heart Failure With Preserved Ejection Fraction Phenotype. Circulation. 2017;135:736-740. DOI:10.1161\/circulationaha.116.025957
    \nhttps:\/\/doi.org\/10.1161\/CIRCULATIONAHA.116.025957<\/p>\n","protected":false},"excerpt":{"rendered":"

    Prof. L.V. Zhuravlyova, as. prof. T.A. Rogachova, as. prof.\u00a0N.V. Sokolnikova. Kharkiv National Medical University Currently, all over the world, type 2 diabetes mellitus and the heart failure are developing into an epidemic. In 1972, Shirley Rubler and colleagues defined cardiomyopathy, which was independent of atherosclerosis and hypertension, as diabetic cardiomyopathy. Recently, the so-called restrictive type…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,9,24,49],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":true,"content":true,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1652"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=1652"}],"version-history":[{"count":7,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1652\/revisions"}],"predecessor-version":[{"id":1885,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1652\/revisions\/1885"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=1652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=1652"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=1652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}