{"id":1647,"date":"2019-11-14T20:50:00","date_gmt":"2019-11-14T17:50:00","guid":{"rendered":"http:\/\/www.internalmed-journal.in.ua\/?p=1647"},"modified":"2020-03-23T15:25:49","modified_gmt":"2020-03-23T12:25:49","slug":"%d0%bc%d0%b8%d0%ba%d1%80%d0%be%d0%b1%d0%b8%d0%be%d1%82%d0%b0-%d0%b8-%d1%81%d0%b5%d1%82%d0%b5%d0%b2%d0%b0%d1%8f-%d0%bc%d0%b5%d0%b4%d0%b8%d1%86%d0%b8%d0%bd%d0%b0","status":"publish","type":"post","link":"http:\/\/www.internalmed-journal.in.ua\/en\/archives\/1647","title":{"rendered":"Microbiota and Network Medicine"},"content":{"rendered":"

Prof. Zh.D Semidotskaya, ass. prof.\u00a0 I.O Chernyakova,\u00a0 ass. prof.\u00a0M.Yu. Neffa, A.E. Chernyakova<\/strong><\/p>\n

Kharkiv National Medical University<\/strong><\/p>\n

Kharkiv Regional Clinical Dispensary for Radiation Protection of the Population<\/strong><\/p>\n

The article outlines the modern understanding of the microbiota as a decentralized network structure, is in constant feedback with the hierarchical network of the host, his brain, cardiovascular, respiratory, urinary, immune systems, forming a microbiota-macrobiont network. The problems of network medicine are highlighted: the relationship between molecular, genetic origin and phenotypic manifestations of various diseases that are manifested through the construction of complex scale-free networks, the importance of social connections of different nature, the role of conscientiousness, observation, competence of the doctor who examines the patient, for the effectiveness of network analysis, the ability to highlight in the network are central nodes that are potential targets for targeted therapy. The main goal at the moment is to build a microbiotic network of human diseases, the central node of which will be the microbiota as the basis for creating a new network paradigm of diseases and their multitarget treatment.<\/p>\n

Key Words:<\/strong> microbiota, network medicine, microbiota-macrobiont network, central nodes, targeted therapy.<\/p>\n

https:\/\/dx.doi.org\/10.15407\/internalmed2019.02.005<\/a><\/p>\n

Download.PDF<\/a><\/p>\n

For citing:<\/p>\n

    \n
  1. \u0421\u0435\u043c\u0438\u0434\u043e\u0446\u043a\u0430\u044f, \u0416.\u0414. \u041c\u0438\u043a\u0440\u043e\u0431\u0438\u043e\u0442\u0430 \u0438 \u0441\u0435\u0442\u0435\u0432\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430 \/ \u0416.\u0414. \u0421\u0435\u043c\u0438\u0434\u043e\u0446\u043a\u0430\u044f, \u0418.\u0410. \u0427\u0435\u0440\u043d\u044f\u043a\u043e\u0432\u0430, \u041c.\u042e. \u041d\u0435\u0444\u0444\u0430, \u0410.\u0415. \u0427\u0435\u0440\u043d\u044f\u043a\u043e\u0432\u0430 \/\/ \u0421\u0445\u0456\u0434\u043d\u043e\u0454\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u044c\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b \u0432\u043d\u0443\u0442\u0440\u0456\u0448\u043d\u044c\u043e\u0457 \u0442\u0430 \u0441\u0456\u043c\u0435\u0439\u043d\u043e\u0457 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0438. – 2019. – \u2116 2. – \u0421. 5-11. doi: 10.15407\/internalmed2019.02.005.<\/li>\n
  2. Semidotskaya ZD, Chernyakova IA, Neffa MYu, Chernyakova AE. [Microbiota and Network Medicine]. Shidnoevr. z. vnutr. simejnoi med. 2019;2:5-11. doi: 10.15407\/internalmed2019.02.005. Russian.<\/li>\n<\/ol>\n

    References:<\/p>\n

    1. Balabantseva AP, Tkach SM, Kliaritskaia IL. Transplantaciya fekal’noj mikrobioty kak effektivnyj metod lecheniya kishechnoj patologii, nekotoryh metabolicheskih i autoimmunnyh zabolevanij [Faecal microbiota transplantation as an effective method of treatment of enteropathy and some metabolic and autoimmune conditions]. Krymskij terapevticheskij zhurnal. 2016;1(28):12-21. Russian.<\/p>\n

    2. Velihov P. Analiz bezmasshtabnyh setej. [Internet]. 2007. Russian. Available from: http:\/\/synthesis.ipi.ac.ru\/sigmod\/seminar\/velikhov.pdf<\/p>\n

    3. Vorobey ES, Voronkova OS, Vinnikov AI. Bakterialni bioplivky. Quorum sensing – \u00abvidchuttia kvorumu\u00bb u bakterii v bioplivkakh [Bacterial biofilms. Bacteria quorum sensing in biofilms]. Visnyk of Dnipropetrovsk University. Biology. Ecology. 2012;20(1):13-22. Ukrainian
    \nhttps:\/\/doi.org\/10.15421\/011202<\/p>\n

    4. Ditert R. Chelovecheskij superorganizm: Kak mikrobiom izmenil nashi predstavlenija o zdorovom obraze zhizni [The Human Superorganism: As a Microbiome change our ideas about a healthy lifestyle]. Per. s angl. Moscow (Russia): Izd. Kolibri, 2017. 416 p. Russian.<\/p>\n

    5. Drapkina OM, Shirobokikh OE. Rol’ kishechnoj mikrobioty v patogeneze serdechno-sosudistyh zabolevanij i metabolicheskogo sindroma [Role of Gut Microbiota in the Pathogenesis of Cardiovascular Diseases and Metabolic Syndrome]. Rational Pharmacotherapy in Cardiology. 2018;14(4):567-574. (In Russ.) https:\/\/doi.org\/10.20996\/1819-6446-2018-14-4-567-574
    \nhttps:\/\/doi.org\/10.20996\/1819-6446-2018-14-4-567-574<\/p>\n

    6. Yevin IA, Rosin AV, Son NP, Chernyshova DI. Setevaya medicina [Network medicine]. Slozhnye sistemy. 2016;1(18):38-47. Russian
    \nhttps:\/\/doi.org\/10.1016\/S1634-7358(16)80632-4<\/p>\n

    7. Ilyina EN, Olekhnovich EI, Pavlenko AV. Rezistom mikrobioty kishechnika kak istochnik formirovaniya lekarstvennoj ustojchivosti vozbuditelej infekcionnyh zabolevanij cheloveka [The gut microbiota resistome provides development of drug resistance in causative agents of human infectious diseases]. Patogenez. 2017;15(3):20-32. Russian.<\/p>\n

    8. Jong Je. Kak mikroby upravljajut nami. Tajnye vlastiteli zhizni na Zemle. Per. s angl.OOO Izd. AST; 2016. 352 . Russian.<\/p>\n

    9. Larin OS, Tkach SM, Tymoshenko OS, Kuzenko JuG. Modyfikacija kyshkovoji mikrobioty i fekaljna transplantacija jak perspektyvni metody likuvannja ozhyrinnja, insulinorezystentnosti i cukrovogho diabetu 2 typu [Modification of intestinal microbiota and faecal transplantation as a perspective method of treatment of obesity, insulin resistance and diabetes mellitus type 2]. Clinical Endocrinology And Endocrine Surgery. 2016;2(54):20-26. Ukrainian. doi: http:\/\/dx.doi.org\/10.24026\/1818-1384.2(54).2016.75861
    \nhttps:\/\/doi.org\/10.24026\/1818-1384.2(54).2016.75861<\/p>\n

    10. Lukichev BG, Rumyantsev AS, Akimenko V. Colonic Microbiota And Chronic Kidney Disease. Message One. Nephrology (Saint-Petersburg). 2018;22(4):57-73. (In Russ.) https:\/\/doi.org\/10.24884\/1561-6274-2018-22-4-57-73
    \nhttps:\/\/doi.org\/10.24884\/1561-6274-2018-22-4-57-73<\/p>\n

    11. Lukichev BG, Rumyantsev AS, Panina IY, Akimenko V. Colonic Microbiota And Chronic Kidney Diseases Intestinal Microbiota And Chronic Kidney Disease. Part II. Nephrology (Saint-Petersburg). 2019;23(1):18-31. (In Russ.) https:\/\/doi.org\/10.24884\/1561-6274-2018-23-1-18-31
    \nhttps:\/\/doi.org\/10.24884\/1561-6274-2018-23-1-18-31<\/p>\n

    12. Mejer E. \u00abVtoroj mozg\u00bb: kak mikroby v kishechnike upravljajut nashim nastroeniem, reshenijami, zdorov’em. Per. S angl. Moskva: Izd. ANF; 2018. 348p. Russian.<\/p>\n

    13. Oleskin AV, Jel’-Registan TI, Shender BL. Mezhmikrobnye himicheskie vzaimodejstvija i dialog mikrobiota-hozjain: rol’ nejromediatorov. Mikrobiologija. 2016;1(85):3-25. Russian.
    \nhttps:\/\/doi.org\/10.7868\/S0026365616010080<\/p>\n

    14. Fadeenko GD, Bogun LV. Disbioz kishechnika v praktike vracha-internista. Suchasna gastroenterolog\u0456ja. 2013;1(69):89-96. Russian.<\/p>\n

    15. Khachaturyan NE, Egshatyan LV. [Intestinal Microbiota Modulation by Metformin] Effective Pharmacotherapy. Endocrinology.2017;4 (43). Russian.<\/p>\n

    16. Hmel’ IA, Metlickaja AZ. Quorum sensing reguljacija jekspressii genov – perspektivnaja mishen’ dlja sozdanija lekarstv protiv patogennosti bakterij Molekul. Biologija . 2006;40:195-210. Russian.<\/p>\n

    17. Shirinskiy VS, Shirinskiy IV. [Hub therapy as a new opportunity for treatment of comorbid diseases]. Sibirskij med. zhurnal. 2014;4:13-21.Russian<\/p>\n

    18. Barabasi AL, Reka A. Emergence of Scaling in random networks. Science, 1999;286:509-512. DOI:10.1007\/978-3-658-21742-6_6
    \nhttps:\/\/doi.org\/10.1007\/978-3-658-21742-6_6<\/p>\n

    19. Barabasi AL. Network Medicine – from Obesity to the “Diseasome”.Barabasi A L. N. Engl. J. Med. 2007;357:404-407. DOI:10.1056\/nejme078114
    \nhttps:\/\/doi.org\/10.1056\/NEJMe078114<\/p>\n

    20. Belisario JE, Faintuch J, Garay M. Gut Microbiome Dysbiosis and Immunometabolism: New Frontiers for Treatment of Metabolic Diseases. Malpartida. Mediators of Inflammation. 2018. Article D 203783812p. DOI:10.1155\/2018\/2037838.
    \nhttps:\/\/doi.org\/10.1155\/2018\/2037838<\/p>\n

    21. Ben-Jacob E. Bacterial survival strategies suggest rethinking cancer cooperativity. Ben-Jacob E, Coffey D S, Levine H. Trends in Microbiology. 2012; 20(9):403-410. DOI:10.1016\/j.tim.2012.06.001.
    \nhttps:\/\/doi.org\/10.1016\/j.tim.2012.06.001<\/p>\n

    22. Brackman G, Coenye T. Quorum sensing inhibitors as anti-biofilm agents. Curr. Pharm.2015; 21; 5-11. DOI:10.2174\/1381612821666150310101014
    \nhttps:\/\/doi.org\/10.2174\/1381612821666150310101014<\/p>\n

    23. Csermeley P, Agoston V, Pongor S. The efficiency of multitarget drugs: the network approach might help drug design. Trends Pharmacol Sci. 2005 Apr;26(4):178-82. DOI:10.1016\/j.tips.2005.02.007.
    \nhttps:\/\/doi.org\/10.1016\/j.tips.2005.02.007<\/p>\n

    24. Delago A, Mandabi A, Meyler MM. Natural Quorum sensing Inhibitors – Small Molecules, Big Messages. Delago A, Mandabi A, Meyler M M. Israel Journal of Chemistry.2015. DOI:10.1002\/ijch.2015. 00052\/
    \nhttps:\/\/doi.org\/10.1002\/ijch.201500052<\/p>\n

    25. Dessaux Y, Chapelle E, Faure D. Quorum sensing and quorum quenching in soil ecosystem. In: G. Witzany (ed). Biocommunication in Soil Microoragnisms. Springer, 2011; 339-369. DOI:10.1007\/978-3-642-14512-4_13
    \nhttps:\/\/doi.org\/10.1007\/978-3-642-14512-4_13<\/p>\n

    26. Dickson RP, Erb- Downward JR, Marttinez FJ, Hulfnagel GB. The Microbiome and the respiratory tract. Ann. Rev. Physiol. 2016;78:481-504. DOI:10.1146\/annurev-physiol-021115-105238
    \nhttps:\/\/doi.org\/10.1146\/annurev-physiol-021115-105238<\/p>\n

    27. Fetzner S. Quorum quenching enzymes. Biothechnol.2015;201: 2-14. DOI:10.1016\/j.jbiotec.2014.09.001
    \nhttps:\/\/doi.org\/10.1016\/j.jbiotec.2014.09.001<\/p>\n

    28. Fujimura KE, Lynch SV. Microbiota in allergy and asthma and the emerging relationship with the gut microbiome. Cell Host Microbe. 2015;17:595-602. DOI:10.1016\/j.chom.2015.04.007
    \nhttps:\/\/doi.org\/10.1016\/j.chom.2015.04.007<\/p>\n

    29. Galla S, Chakraborty BM, Vijay JB. Microbiotal- Host interaction and hypertension. Kumar. Physiology. 2017;32:224-233. DOI:10.1152\/physiol.00003.2017
    \nhttps:\/\/doi.org\/10.1152\/physiol.00003.2017<\/p>\n

    30. Garding S, Verbeke K, Vipond DT, Corfe BM, Oven LJ. Dysbiosis of the gut microbiota in disease. Microb Ecol Health Dis. 2015; Feb2; 26:26191. doi:10.3402\/mehd. v.26. 26191 ecollection 2015.
    \nhttps:\/\/doi.org\/10.3402\/mehd.v26.26191<\/p>\n

    31. Grandelement C, Tanniers M, Morena S, Dessaux Y, Faure D. Quorum quenching: role in nature and applied developments. FEMC Microbiol.Rev. 2016;40(1):86-116. DOI:10.1093\/femsre\/fuv038
    \nhttps:\/\/doi.org\/10.1093\/femsre\/fuv038<\/p>\n

    32. Guo N. Network Medicine: New Paradigm in the Omics – Era. Anatomy physiol. 2011;1:1: e 106. DOI:10, 4172( 2161-0940. 1000 e 106<\/p>\n

    33. Gupta SU, Allen-Vercol E, Petrof EO. Fecal microbiota transplantation: in perspective. Therap Ady Gastroenterol.2016;9(2):229-239. DOI:10.1177\/1756283×15607414
    \nhttps:\/\/doi.org\/10.1177\/1756283X15607414<\/p>\n

    34. Hidalgo CA, Bluimm N, Barabasi AL, Christakis NA dynamic network approach for the study of humans phenotypes. PLos. Comput. Biol.2009;5e 1000353. DOI:10.1371\/journal.pcbi.1000353
    \nhttps:\/\/doi.org\/10.1371\/journal.pcbi.1000353<\/p>\n

    35. Jamai M, Ahmad W, Andbeb S, Jalil F, Imran M, Navaz M, Cussian T Y, Ali M, Rafiq M, Kamil MA. J Bacterial Biofilm and associated infections. Clin.Med.Assoc.2018;81(1):7-11. DOI:10.1016\/j.jcma.2017.07.012
    \nhttps:\/\/doi.org\/10.1016\/j.jcma.2017.07.012<\/p>\n

    36 Li L, Alderson D, Tanaka R, Doyle J C, Willinger W. Towards a Theory of Scale – Free Graphs: Definition, Properties, and Implications (Exten ded Version). . Internet Mathematics. 2005. DOI:10.1080\/15427951.2005.10129111
    \nhttps:\/\/doi.org\/10.1080\/15427951.2005.10129111<\/p>\n

    37. Martinez J L. General prinziplez of antibiotic resistance in bacteria. Drug Discavery Today: Technologist. 2014;11:33-39. DOI:10.1016\/j.ddtec.2014.02.001
    \nhttps:\/\/doi.org\/10.1016\/j.ddtec.2014.02.001<\/p>\n

    38. Marx P, Anfal P, Bolgar B, Badgy G, Deakin D, Juhazz G. Comorbidities in the diseasome are more apparent than real what Bayesian filtering reveals about the comorbidities of depression. PLoS Comut Biol.2017;13(6): e 1005487. DOI:10.1371\/journal.pcbi.1005487
    \nhttps:\/\/doi.org\/10.1371\/journal.pcbi.1005487<\/p>\n

    39. Norris V, Molina F, Gewitz A T. J. Hypothesis: bacteria control host appetites. Bacteriol; 2013;195: 411-416. DOI:10.1128\/jb.01384-12
    \nhttps:\/\/doi.org\/10.1128\/JB.01384-12<\/p>\n

    40. Oleskin AV. Network structures biological systems. Biol. Bull.Rev; 2014;74(1):47-70. DOI:10.1134\/s2079086414010034
    \nhttps:\/\/doi.org\/10.1134\/S2079086414010034<\/p>\n

    41. Perry JA, Westman EL, Wright GD. The antibiotic resistome: What’s new? Curr.Opin. Microbiol. 21:45-50. DOI:10.1016\/j.mib.2014.09.002
    \nhttps:\/\/doi.org\/10.1016\/j.mib.2014.09.002<\/p>\n

    42. Remeli M, Stephanska B, Lovretic L. Nutriepigenomics the role of nutrition in epigenetic control of human diseases. Curr. Opin. Clin. Nutr. Metab. Care. 2015;18(4):28-333. DOI:10.1097\/00075197-199803000-00016
    \nhttps:\/\/doi.org\/10.1097\/00075197-199803000-00016<\/p>\n

    43. Remy B, Mion S, Pluer L, Elias M, Chabriere E, Daude D.Interference in Bacterial Quorum Sensing: A Biopharmaceutical Perspective Front. Pharmacol. 2.-9:203. DOI:103389\/fpharm. 2018\/ 00203
    \nhttps:\/\/doi.org\/10.3389\/fphar.2018.00203<\/p>\n

    44. Santisteban MM, Kim S, Pepine CJ, Razada MK. Brain-gut-bone marrow axis: implications for hypertension fnd related therapeutics. Circ. Res. 2016;118:1327-1336. DOI:10.1161\/circresaha.116.307709
    \nhttps:\/\/doi.org\/10.1161\/CIRCRESAHA.116.307709<\/p>\n

    45. Smith M, Kelly C, Alm E. How to regulate faecal transplants. Nature.2014;606:290-291. DOI:10.1038\/506290a
    \nhttps:\/\/doi.org\/10.1038\/506290a<\/p>\n

    46. Sontheimer E J. The Bacterial Origins of the CRISPR GenomeEdition Revolution. Sontheimer E J, Barrangon R. Human Gene Therapy. 2015;26(7):413 – 424. DOI:10.1089\/hum.2015.091
    \nhttps:\/\/doi.org\/10.1089\/hum.2015.091<\/p>\n

    47. Stilling RM, Bordenstein SR, Dinan TG, Cryan JF. Friends with social benefits: host-microbe interaction as a driver of brain evolution and development. Front. Cell. infect. Microbiol.; 2014; 4. Doi: 103389\/ fsimb. 2014. 00147
    \nhttps:\/\/doi.org\/10.3389\/fcimb.2014.00147<\/p>\n

    48. Tang WH, Kitai T, Hazen SL Gut microbiota in cardiovascular disease. Circ. Res. 2017;120(7):1183 – 1196. DOI:10.1161\/circresaha.117.309715
    \nhttps:\/\/doi.org\/10.1161\/CIRCRESAHA.117.309715<\/p>\n

    49. Thompson CM, Marsden AE, Tischler AH, Koo J, Visick KL. Vibrio fischeri Biofilm Formation Prevented by a Trio of Regulators. Appl. Environ Microbiol. 2018;84(19). e01257-18. DOI:10.1128\/aem.01257-18
    \nhttps:\/\/doi.org\/10.1128\/AEM.01257-18<\/p>\n

    50. Vila J. Microbiota transplantation and \/or CRISPR \/ CAS in the battle against antimicrobial resistance. Clin. Microbiol. And Inf. 2018;24(7):684-688. DOI:10.1016\/j.cmi.2018.03.043
    \nhttps:\/\/doi.org\/10.1016\/j.cmi.2018.03.043<\/p>\n

    51. Wing MC, Patel SS, Ramesani A, Rai DS. Gut microbiome in chronic kidney disease. Exp. Physiol. 2016;101:477-479. DOI:10.1113\/ep085283
    \nhttps:\/\/doi.org\/10.1113\/EP085283<\/p>\n

    52. Yildrim M, Goh K, Gusik M, Barabasi A L, Vidali M Drug – target network. Nature biotechnology. 2007;25(10). DOI:10.1038\/nbt1338
    \nhttps:\/\/doi.org\/10.1038\/nbt1338<\/p>\n

    53. Zhou X, Menche J, Barab\u00e1si AL, Sharma A. Human symptoms-disease network. Nat Commun. 2014 Jun 26;5:4212. doi: 10.1038\/ncomms5212. PubMed PMID: 24967666.
    \nhttps:\/\/doi.org\/10.1038\/ncomms5212<\/p>\n","protected":false},"excerpt":{"rendered":"

    Prof. Zh.D Semidotskaya, ass. prof.\u00a0 I.O Chernyakova,\u00a0 ass. prof.\u00a0M.Yu. Neffa, A.E. Chernyakova Kharkiv National Medical University Kharkiv Regional Clinical Dispensary for Radiation Protection of the Population The article outlines the modern understanding of the microbiota as a decentralized network structure, is in constant feedback with the hierarchical network of the host, his brain, cardiovascular, respiratory,…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8,49],"tags":[],"translation":{"provider":"WPGlobus","version":"2.12.2","language":"en","enabled_languages":["uk","en","ru"],"languages":{"uk":{"title":true,"content":true,"excerpt":false},"en":{"title":true,"content":true,"excerpt":false},"ru":{"title":true,"content":true,"excerpt":false}}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1647"}],"collection":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/comments?post=1647"}],"version-history":[{"count":10,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1647\/revisions"}],"predecessor-version":[{"id":1884,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/posts\/1647\/revisions\/1884"}],"wp:attachment":[{"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/media?parent=1647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/categories?post=1647"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.internalmed-journal.in.ua\/en\/wp-json\/wp\/v2\/tags?post=1647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}